Application of babysbreath isoorientin for preparing medicines for treating alcoholic liver injury

A technology of alcoholic liver injury and Gypsophila gypsophila, applied in the field of application in the preparation of drugs for the treatment of alcoholic liver injury

Inactive Publication Date: 2013-09-18
黄权芳 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Gypsophila elegans Bieb (Gypsophila elegans Bieb), also known as carnation, Xiacao, etc., is a plant of the genus Stone Flower in the family Caryophyllaceae [1] , is a traditional anti-liver dis

Method used

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  • Application of babysbreath isoorientin for preparing medicines for treating alcoholic liver injury

Examples

Experimental program
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Effect test

Example Embodiment

[0016] 1. Preparation of Gypsophila isoorientin

[0017] Extraction method: 10 kg of dried baby's breath is pulverized, and then extracted 3 times with 80 L of 75% ethanol at reflux, and the 3 ethanol extracts are combined to recover the ethanol to obtain 315.7 g of ethanol extract. The ethanol extract was mixed with 630ml of distilled water and shaken to form a suspension, and then extracted with petroleum ether, ethyl acetate and n-butanol in sequence. The extraction method is briefly described as follows: First, extract with 630ml of petroleum ether and discard the petroleum ether solution; Extract with 630ml of ethyl acetate, discard the ethyl acetate solution; finally, extract with 630ml of n-butanol to recover the n-butanol to obtain 177.6 g of the n-butanol extract.

[0018] Purification method: D101 type macroporous resin was applied to the n-butanol extract, first eluted with 5 times the amount of water, and then eluted with 10 times the amount of 90% methanol to recover t...

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Abstract

The invention discloses an applicative research of an active ingredient of a traditional Chinese medicine babysbreath isoorientin for preparing medicines for treating alcoholic liver injury. First, the babysbreath isoorientin for treating alcoholic liver injury is researched, and animal experiments show that the for the babysbreath isoorientin can be acted on a plurality of links or targets of alcoholic liver injury, and effectively inhibits lipid peroxidation reaction, alleviates pathological injury of liver tissues, inhibits collagen deposition and accelerates apoptosis of hepatic stellate cells, so that the liver injury is remarkably alleviated. The babysbreath isoorientin has unique advantage to prevent and treat liver injury, and is a very potential novel medicine for treating alcoholic liver injury.

Description

technical field [0001] The present invention relates to the use of the extract of the traditional Chinese medicine Gypsophila gypsophila, in particular the application of the gypsophila isoorientin as a raw material in the preparation of drugs for treating alcoholic liver injury. Background technique [0002] Alcoholic liver injury caused by alcoholism is an important pathological process for the development of alcoholic liver disease to cirrhosis, and many studies have confirmed that it can still be reversed. Therefore, effective treatment of alcoholic liver injury is not only a good opportunity to treat alcoholic liver disease, but also to block or The key to delaying the progression of chronic alcoholic liver disease to cirrhosis. At present, there is still no clear plan and effective drug for the clinical treatment of alcoholic liver injury. In recent years, a large number of studies at home and abroad have shown that natural medicines and traditional Chinese medicines ...

Claims

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Application Information

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IPC IPC(8): A61K36/10A61P1/16
Inventor 黄权芳林兴陈永欣黄仁彬张士军吕淑娟韦玲梁春宏
Owner 黄权芳
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