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Use of cerebrosid-kinin in preparation of medicine for preventing and treating peripheral nerve disease

A technology for peripheral nerve and peripheral nerve injury, which is applied in the field of medicine and can solve the problems that there are no reports on the prevention and treatment of peripheral nerve diseases by cerebroside and carnosine.

Inactive Publication Date: 2006-04-26
诺氏制药(吉林)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] But so far, there is no report of cerebroside carnosine in the prevention and treatment of peripheral nerve diseases

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] step 1):

[0041] Take 10kg of fresh rabbit muscle, add 10L water to homogenate, freeze after homogenization, freeze and thaw twice, heat at 60°C after thawing, keep warm for 20 minutes, and centrifuge after cooling down, the centrifugation condition is 4000 rpm, and the centrifugation time is 20 minutes , retain the supernatant, filter the supernatant to obtain the filtrate; add trypsin to the filtrate and heat-preserve for hydrolysis, the trypsin concentration is 0.2%, the hydrolysis conditions are pH=7.8, heat preservation at 37°C, and the heat preservation time is 2 hours; after enzymolysis , the pH value of the enzymolysis solution was adjusted to 3.8, heated to 80°C, kept for 20 minutes, and then centrifuged after cooling down, the centrifugation condition was 4000 rpm, and the centrifugation time was 20 minutes, the supernatant was retained, and the supernatant was filtered to obtain the filtrate.

[0042] Adjust the pH value of the filtrate to 6.8, freeze, and c...

Embodiment 2

[0051] step 1):

[0052] With embodiment 1 step (1).

[0053] Step (2):

[0054] With embodiment 1 step (2). Take 10 kg of fresh pig brain and homogenize it with 35 L of acetone. Referring to the step of Example 1, prepare a pig brain ganglioside extract for future use. The concentration is 400 μg of sialic acid per 1 ml.

[0055] According to the operation of Example 5, cerebroside carnosine injection was prepared.

Embodiment 3

[0057] With reference to steps (1) and (2) in Example 1, step (3) after mixing the muscle extract and the brain ganglioside extract, make granules according to a method known to those skilled in the art, and press after drying Tablets are obtained to obtain tablets of the pharmaceutical composition.

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PUM

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Abstract

Disclosed is the novel use of glycoside and ignotin in the preparation of medicaments for treating diseases of peripheral nerves, wherein the glycoside and ignotin comprises active compounds such as polypeptides and ganglioside. The cattle encephalon glycoside and ignotin can be mixed with medically acceptable auxiliary materials to obtain medicinal composition in the dosage forms of tablets, capsules, granules, drop pills, injections and eye drops.

Description

【Technical field】 [0001] The invention relates to the field of medicine, in particular to a new application of cerebroside and carnosine, and more specifically to the application of cerebroside and carnosine in the preparation of drugs for preventing and treating peripheral nerve diseases. 【Background technique】 [0002] Cerebroside and carnosine injection, such as the one produced by Northeast Pharmaceuticals (Jilin) ​​Co., Ltd. (National Drug Approval H22025046), contains active peptides and various active ingredients such as gangliosides. It has been clinically proven that it can promote brain tissue Metabolism, participate in the growth, differentiation and regeneration of brain tissue neurons, improve cerebral blood circulation and brain metabolic function, can be used to treat dysfunction caused by brain diseases, and can be used to treat dementia, traumatic brain injury, cerebral edema and other diseases; It is also used for the treatment of senile dementia, cerebrova...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17A61K9/08A61K9/16A61K9/20A61K9/48A61K35/34A61K38/02A61P25/02
Inventor 杨尚华
Owner 诺氏制药(吉林)有限公司
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