Preparation method and application for 99mTc-labelled hydrazino-nicotinamide-5-aminopentanoic acid-pteroyl lysine complex
A technology of pteroyl lysine and aminovaleric acid, which is applied in the field of preparation of hydrazinyl nicotinamide-5-aminovaleric acid-pteroyl lysine complexes, can solve the problem that the ratio of target to non-target is not ideal, Uptake of advanced issues
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment Construction
[0020] Describe the present invention in detail below by embodiment: a kind of 99m Tc-labeled hydrazinyl nicotinamide-5-aminovaleric acid-pteroyl lysine complex:
[0021] Its structural formula is:
[0022]
[0023] In the structural formula: the nitrogen atom of the hydrazine group in the ligand HYNIC-penta-lys-Pteroyl (hydrazinyl nicotinamide-5-aminovaleric acid-pteroyl lysine) molecule, the oxygen atom in the co-ligand Tricine and TPPTS molecule with phosphorus atom and 99m Tc is coordinated to obtain 99m Te(HYNIC-penta-lys-Pteroyl)(Tricine / TPPTS) complex.
[0024] 99m The preparation method of the Tc-labeled hydrazinonicotinyl-5-aminovaleric acid-pteroyl lysine complex is as follows:
[0025] a. The synthesis of ligand pteroyllysine-5-aminovaleric acid-6-(2-N, N-dimethylbenzaldehyde hydrazono) nicotinic acid, the specific synthetic route is as follows:
[0026]
[0027] Pteroyllysine-5-aminovaleric acid (20 mg, 0.037 mmol) was dissolved in 10 ml of anhydrous DM...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com