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Method for preparing eight-treasure granules

A Bazhen granule and formula technology, applied in the field of Bazhen granule preparation, can solve the problems of unqualified product quality, low proportion of excipients, unqualified properties, etc., and achieve saving of process and energy consumption, simple preparation process and stable drug quality Effect

Active Publication Date: 2015-02-11
NINGBO LIWAH PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Bazhen granules are made from the compatibility of eight traditional Chinese medicines, and the prescription volume is relatively large. The content in the drug is relatively large, and the proportion of excipients is relatively small. It is easy to make preparations difficult to form, or it is easy to absorb moisture and agglomerate, causing problems such as excessive moisture and unqualified properties, which will make the product quality unqualified and affect the industrial production of drugs. It is difficult to satisfy doctors. and patient needs

Method used

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  • Method for preparing eight-treasure granules
  • Method for preparing eight-treasure granules
  • Method for preparing eight-treasure granules

Examples

Experimental program
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Effect test

Embodiment 1

[0020] Codonopsis, Angelica, Chuanxiong, Rehmannia glutinosa, Atractylodes macrocephala, Licorice, Radix Paeoniae Rubra, Poria cocos medicinal materials were collected and processed in accordance with the 2010 edition of the Chinese Pharmacopoeia and "Zhejiang Traditional Chinese Medicine Processing Standards" (2005 edition) to prepare various Chinese herbal medicine pieces.

[0021] Codonopsis: Take Codonopsis pilosula medicinal materials, remove impurities, wash, moisturize, cut into thick slices, and dry.

[0022] Angelica decoction pieces: take the herbal medicine of Angelica, remove impurities, wash, moisturize, cut into thin slices, sun-dried or low-temperature drying.

[0023] Chuanxiong decoction pieces: take Chuanxiong medicinal materials, remove impurities, separate the size, soak slightly, wash, moisturize, cut into thin slices, and dry.

[0024] Rehmannia glutinosa decoction pieces: take the rehmannia glutinosa medicinal material, remove impurities, wash, moisturize, cut in...

Embodiment 2

[0030] Weigh the processed Chinese herbal medicine pieces in Example 1, respectively, 48K parts by weight of Codonopsis, 48K parts by weight of Fried Atractylodes, 48K parts by weight of Poria, 24K parts by weight of Roasted Licorice, 72K parts by weight of Angelica, 48K parts by weight of Fried White Peony, 36K parts by weight of Chuanxiong , 72K parts by weight of Rehmannia, spare.

[0031] Mix the weighed Angelica sinensis, Chuanxiong, and Stir-fried Atractylodes macrocephala, and then use 5 times the amount of 95% ethanol and 5 times the amount of 50% ethanol of the above-mentioned three-flavored Chinese medicine pieces to be heated and refluxed for 2 hours respectively, and filtered to obtain the filtrate and medicine residue. The filtrate is combined and concentrated for recovery Ethanol, the concentrated liquid is filtered, and the filtrate is reserved; the medicine residue is mixed with the other five flavors of Codonopsis, Poria (decoction), roasted licorice, fried white ...

Embodiment 3

[0035] Take a portion of the extract prepared in Example 2, add sucrose and an appropriate amount of dextrin as excipients, granulate, dry, and sizing to prepare 200K parts by weight of granules, and pack them into 8 parts by weight per bag. Get the sugar-containing Bazhen granule product.

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Abstract

The invention provides a method for preparing eight-treasure granules. The method comprises the following steps: eight medical materials such as radix codonopsis and bighead atractylodes rhizomes are prepared into Chinese herbal pieces as requested; the angelica sinensis, the ligusticum wallichii and the roasted bighead atractylodes rhizomes are extracted through ethanol reflux after being mixed and ethanol is recovered; the dregs of the decoctions of the angelica sinensis, the ligusticum wallichii and the roasted bighead atrac tylodes rhizome are added with water and then are decocted, wherein the dregs are continuously extracted through the ethanol at a low temperature; the remaining five Chinese herbal pieces such as the radix codonopsis, the Indian buead, the prepared rehmannia roots and the honey-fried licorice roots are added with water and then are decocted; the extracted solutions are mixed and then are concentrated into extractum with a hot test density of 1.08 to 1.20; the extractum is added with ethanol for ethanol precipitation and stilly placed; the supernatant are taken away, the ethanol is recovered, then the solution is concentrated into extractum with a hot test density 1.35-1.38; the extractum is added with auxiliary materials to be made into sugary granules and sugarless granules. According to the method, drug effective ingredients are reserved to the maximum extent; the quantity of the extractum extracted from the eight treasures are remarkably reduced; the problems that in the actual production process, prepared agents are difficult to form and the original technology is susceptible to moisture absorption and caking are solved, so that the method is suitable for industrial production and enables the quality of the drug more stable.

Description

Technical field [0001] The invention relates to a preparation method of Chinese patent medicine, in particular to a preparation method of Bazhen granules. Background technique [0002] Bazhen Granules are included in the 2010 edition of the Chinese Pharmacopoeia, and are composed of eight Chinese herbs from Codonopsis, Fried Atractylodes, Poria, Roasted Licorice, Angelica, Fried White Peony, Chuanxiong, and Rehmannia glutinosa. Bazhen granules have the function of invigorating qi and blood, and are used to treat deficiency of qi and blood, chlorosis, loss of appetite, weakness of limbs, and menorrhagia. Bazhen Granules are made up of eight Chinese medicines, with a large prescription. Codonopsis, Fried Atractylodes, Poria, Roasted Licorice, Angelica, Fried White Peony, Chuanxiong, and Rehmannia glutinosa eight-flavored traditional Chinese medicine decoction pieces are pre-processed and extracted. The content in the drug is large, the proportion of excipients is small, it is easy...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/804A61K9/16A61P1/14A61P15/00
Inventor 江海龙周海滨冯定军俞伟胡黎凤刘帮民
Owner NINGBO LIWAH PHARM CO LTD
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