Male antifertility drug and application

An anti-fertility drug, androgenic technology, applied in the direction of diseases, drug combinations, medical raw materials derived from gymnosperms, etc., can solve the problem of insufficient extraction, separation and identification of effective monomer components, identification of Tripterygium wilfordii monomer Doubts and controversies about different effects, etc., to achieve good anti-fertility effects, accelerated decline in sperm motility, and rapid drug onset

Active Publication Date: 2015-06-03
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(2) High failure rate
The results of animal experiments show that there is controversy about the different effects of different monomers
In addition, foreign authoritative organizations also have doubts about the identification of Tripterygium wilfordii monomer
Although there are reports of antifertility effects in patients with autoimmune diseases after using GTW, there is currently a lack of prospective, controlled, contraceptive efficacy clinical trials in healthy men designed to confirm antifertility efficacy at non-immunosuppressive doses Safety, security and reversibility
In addition, preclinical basic research work, especially the extraction, separation and identification of effective monomer components is not sufficient

Method used

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  • Male antifertility drug and application
  • Male antifertility drug and application
  • Male antifertility drug and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] This example is used to illustrate the preparation of the male antifertility drug provided by the present invention.

[0054] The cones of the fork juniper (Sabina vulgaris Ant) were naturally dried at 30° C. (relative humidity 15%) for 300 hours, so that the water content after drying was less than 10% by weight. And carry out wet pulverization (the weight ratio of described fork juniper cone and water is 31:69), the average particle diameter distribution range of the Juniper cones after crushing was less than or equal to 80 microns, and the slurry of the male antifertility drug LTQ-1 was obtained.

Embodiment 2

[0056] This example is used to illustrate the preparation of the male antifertility drug provided by the present invention.

[0057] The cones of Sabina vulgaris Ant were freeze-dried at -20°C (relative humidity 10%) for 240 hours, so that the water content after drying was less than 10% by weight. And the dried Chinese medicine pulverizer (DJ-02, Shanghai Dianjiu Traditional Chinese Medicine Machinery Manufacturing Co., Ltd.) pulverizes the dried fork juniper cones until the average particle diameter distribution range is less than or equal to 60 microns to obtain the male antifertility drug LTQ-2 dry powder.

Embodiment 3

[0059] This example is used to illustrate the preparation of the male antifertility drug provided by the present invention.

[0060] The cones of Sabina vulgaris Ant were naturally dried at 20°C (relative humidity 15%) for 450 hours, so that the water content after drying was less than 10% by weight. And the dried fork juniper cones are pulverized with a plant grinder (Great Wheel brand plant grinder, manufactured by Hebei Huanghua Qijiawu Scientific Instrument Factory) until the average particle diameter distribution range is less than 100 microns to obtain the male antifertility drug LTQ-3 dry powder.

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Abstract

The invention provides a male antifertility drug and an application. The male antifertility drug is acquired by drying cones of Sabina vulgaris and pulverizing. The male antifertility drug provided by the invention is applied to male rats, male dogs and acts upon human sperms, and a good antifertility function can be achieved and is invertible.

Description

technical field [0001] The invention relates to a male antifertility drug and its application. Background technique [0002] At present, the only effective methods for male fertility regulation in the world are in vitro ejaculation, condoms and vasectomy. These methods have been used for more than a century. Except for some small improvements, there is no innovation so far. However, domestic and foreign scientists have been discussing the purpose of male fertility regulation through drugs. There are two main aspects of drug research for male fertility regulation: steroidal hormone male contraceptives and non-steroidal hormone natural herbal medicines. [0003] (1) Research on steroid hormone male contraceptives [0004] Interfering with the regulation of the hypothalamus-pituitary-testis axis by administering exogenous androgen to inhibit spermatogenesis, and at the same time supplementing the concentration of androgen in peripheral blood to play a physiological role is th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/14A61P15/16A61K131/00
Inventor 钱越英佟振合刘新厚
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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