Counterfeit drug discrimination and analysis device and method based on folding curve screening method

A technology for discriminant analysis and counterfeit medicine, applied in the field of counterfeit medicine discriminant analysis device, can solve problems such as interference analysis results, and achieve the effects of improving efficiency and speed, improving accuracy and sensitivity, and improving resolution and signal-to-noise ratio.

Inactive Publication Date: 2015-08-05
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Abstract
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Problems solved by technology

[0013] It can be seen that although the accuracy and sensitivity of the fold curve analysis method are good, at the same time, due to the strong characteristics and rich information of the Raman spectrum, the information of other irrelevant components will also greatly interfere with the analysis results. Therefore, if you want to The use of the fold curve analysis method for Raman spectroscopy requires further improvement in combination with the characteristics of the Raman spectrum, so as to obtain an improved fold curve screening analysis method suitable for Raman spectroscopy to improve the accuracy of the analysis method. Discrimination accuracy

Method used

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  • Counterfeit drug discrimination and analysis device and method based on folding curve screening method
  • Counterfeit drug discrimination and analysis device and method based on folding curve screening method
  • Counterfeit drug discrimination and analysis device and method based on folding curve screening method

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Experimental program
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Effect test

Embodiment

[0109] 1. Materials and equipment

[0110] 1. Tablets and compound samples: Genuine drug samples are: 5 genuine glibenclamide tablets with known content of main drug ingredients, 5 genuine drug tablets with known content of main drug ingredients Gliclazide; main drug ingredients control Products: glibenclamide reference substance, gliclazide reference substance; samples to be tested are: 5 glibenclamide tablets, 5 gliclazide tablets, sucrose, dextrin, starch, PVPK30, talcum powder, hard Magnesium fatty acid, pregelatinized starch, carboxymethyl starch, hydroxypropyl cellulose, lactose, microcrystalline cellulose, hydroxypropyl methylcellulose.

[0111] 2. Counterfeit drug analysis system: the computer hardware system adopts Dual E2180 2.00GHz chip, the calculation software is VB (fold transformation), matlab7.0 (correlation coefficient calculation), and the TruScan portable Raman spectrometer of Thermo Company.

[0112] 2. Experimental steps:

[0113] 1. Scrape off the sur...

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PUM

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Abstract

The invention relates to a convoluted curve screening process based counterfeit drug discrimination analysis method, a counterfeit drug discrimination analysis apparatus, and a counterfeit drug analysis system comprising the counterfeit drug discrimination analysis apparatus. The method is characterized in that the characteristic information, that is, characteristic spectrum coverage in the drug spectrum is screened through combining the quantitative analysis and qualitative analysis of a substance on the basis of the convoluted transformation in a convoluted curve analysis process, and the drug truth is discriminated through utilizing the characteristic spectrum coverage. The counterfeit drug discrimination analysis apparatus, the counterfeit drug analysis system and the counterfeit drug discrimination analysis method can realize the rapid and simple truth discrimination of a tablet to be measured only through few true tablets and the spectrum of the above compound to be measured.

Description

technical field [0001] The invention relates to a device for discriminating and analyzing counterfeit medicines based on a folding curve screening method, a system for discriminating and analyzing counterfeit medicines including the device for discriminating and analyzing counterfeit medicines, and a method for discriminating counterfeit medicines. Background technique [0002] The existence of counterfeit drugs not only seriously affects the safety and effectiveness of people's medication, but also restricts the rapid development of social economy. It is currently one of the common problems faced by all countries in the world, especially developing countries. The crackdown on counterfeit drugs, especially the rapid detection of drugs at the grass-roots level, the reduction of sampling costs, and the improvement of sampling coverage and work efficiency are urgent tasks. [0003] The prevention and combat of counterfeit medicines depend to a large extent on the capabilities o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/65
Inventor 陆峰柳艳柴逸峰吴玉田范国荣朱振宇亓云鹏
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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