Optical waveguide measurement system and method for measuring glycated hemoglobin

A technology of glycosylated hemoglobin and measurement system, which is applied in the field of optical waveguide measurement system, and can solve the problems of large-scale equipment, high cost, and complicated processing

Inactive Publication Date: 2013-12-04
TOSHIBA MEDICAL SYST CORP
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, with complex preprocessing
Recently, the high-performance liquid chromatography (HPLC) method is becomin...

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  • Optical waveguide measurement system and method for measuring glycated hemoglobin
  • Optical waveguide measurement system and method for measuring glycated hemoglobin
  • Optical waveguide measurement system and method for measuring glycated hemoglobin

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Embodiment Construction

[0017] Embodiments will be described below with reference to the drawings. In the following description, the same reference numerals are assigned to the same components.

[0018] Figure 1A and Figure 1B is a schematic cross-sectional view of the optical waveguide measurement system of the first embodiment, Figure 1A is a schematic cross-sectional view showing the entire optical waveguide measurement system, Figure 1B It is an enlarged schematic cross-sectional view of the vicinity of the first substance fixed to the optical waveguide of the optical waveguide type measurement system.

[0019] The optical waveguide measurement system 30 of the first embodiment includes: an optical waveguide 3 (first optical waveguide); Hemoglobin-specific binding; second substance 13; multiple magnetic fine particles 9 (first magnetic fine particles); liquid (water, organic solvent) or other dispersion medium 25 (first dispersion medium). The second substance 13 is immobilized on each of ...

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Abstract

According one embodiment, an optical waveguide measurement system includes a first optical waveguide immobilizing a first substance, the first substance being able to be specifically bound to glycated hemoglobin; a plurality of first magnetic microparticles immobilizing a second substance immobilized, the second substance being able to be specifically bound to the glycated hemoglobin at a first site different from a second site, and the first substance can be specifically bound to the glycated hemoglobin at the second site; a first magnetic field applying section provided above the first optical waveguide and being able to move at least one of the plurality of first magnetic microparticles by magnetic force; a first light source being able to inject light into the first optical waveguide; and a first light receiving element being able to receive light ejected from the first optical waveguide.

Description

[0001] This application claims priority from a prior Japanese Patent Application No. 2012-112871 filed on May 16, 2012, the entire contents of which are incorporated herein by reference. technical field [0002] The present invention relates to an optical waveguide type measuring system and a method for measuring glycated hemoglobin. Background technique [0003] HbA1c (glycosylated hemoglobin) is produced when sugar in the blood enters red blood cells and irreversibly combines with hemoglobin, and reflects the average blood sugar level in the past 1 to 2 months. Therefore, HbA1c is widely used as an index for diabetes diagnosis such as screening tests for diabetes and grasping the state of blood sugar management of diabetic patients. [0004] Methods for measuring HbA1c include a latex aggregation method and a method using protease. Although the latex coacervation method is easy to operate, in order to measure the turbidity of the bulk, the apparatus becomes large, and the...

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Application Information

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IPC IPC(8): G01N33/72G01N33/543G01N33/577G01N21/01
CPCG01N33/54373G01N33/54333G01N33/723
Inventor 葛西晋吾东野一郎
Owner TOSHIBA MEDICAL SYST CORP
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