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Temperature-sensitive gel composition and preparation method thereof

A gel composition, sensitive technology, applied in the medical field, can solve the problem of destroying blood vessels, can not ensure that the operation area is blood-free, and achieve the effect of prolonging the time of blood flow block

Active Publication Date: 2013-12-11
江苏贝佳制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, some commonly used hemostatic tools (such as hemostats or rubber bands) cannot ensure that the surgical area is free of blood and may damage blood vessels

Method used

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  • Temperature-sensitive gel composition and preparation method thereof
  • Temperature-sensitive gel composition and preparation method thereof
  • Temperature-sensitive gel composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031]

[0032] Preparation,

[0033] 1. Dissolve the prescribed amount of poloxamer 407 in water, add the prescribed amount of glutamic acid and polyethylene glycol 600, stir to dissolve, and make a temperature-sensitive gel solution. Control the temperature at 5°C.

[0034] 2. Use glutamic acid aqueous solution or sodium hydroxide solution to adjust the pH of the temperature-sensitive gel solution to 4.0. Add 0.1% activated carbon, stir for 15 minutes, and control the temperature at 8°C.

[0035] 3. Filter to remove the activated carbon and control the temperature to 5°C.

[0036]4. Fill it into ampoules or pre-filled syringes, control the filling volume to 2-10ml, and control the temperature of the liquid storage room, system and environment of the filling machine to 10°C.

[0037] 5. Seal the ampoule.

[0038] 6. Sterilize at 121°C for 15 minutes.

Embodiment 2

[0040]

[0041] Preparation,

[0042] 1. Dissolve the prescribed amount of poloxamer 407 in water, add the prescribed amount of aspartic acid and polyethylene glycol 600, stir to dissolve, and make a temperature-sensitive gel solution. Control the temperature at 5°C.

[0043] 2. Use aspartic acid aqueous solution or sodium hydroxide solution to adjust the pH of the temperature-sensitive gel solution to 4.0. Add 0.1% activated carbon, stir for 15 minutes, and control the temperature at 8°C.

[0044] 3. Filter to remove the activated carbon and control the temperature to 5°C.

[0045] 4. Fill it into a pre-filled syringe, control the filling volume to 2-10ml, and control the temperature of the liquid storage chamber, system and environment of the filling machine to 10°C.

[0046] 5. Sterilize at 121°C for 15 minutes.

Embodiment 3

[0048]

[0049] 1. Dissolve the prescribed amount of poloxamer 407 in water, add the prescribed amount of glutamic acid, aspartic acid and polyethylene glycol 800, stir to dissolve, and make a temperature-sensitive gel solution. Control the temperature at 5°C.

[0050] 2. Use aspartic acid aqueous solution or sodium hydroxide solution to adjust the pH of the temperature-sensitive gel solution to 4.0. Add 0.1% activated carbon, stir for 15 minutes, and control the temperature at 8°C.

[0051] 3. Filter to remove the activated carbon and control the temperature to 5°C.

[0052] 4. Fill it into an ampoule, control the filling volume to 5-20ml, and control the temperature of the liquid storage room, system and environment of the filling machine to 10°C.

[0053] 5. Seal the ampoule.

[0054] 6. Sterilize at 121°C for 15 minutes.

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PUM

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Abstract

The invention relates to a temperature-sensitive gel composition containing poloxamer 407, acidic amino acid, polyethylene glycol and water and a preparation method thereof. In a surgical operation, the temperature-sensitive gel composition is injected into a blood vessel to form a gel suppository so as to realize a hemostatic effect.

Description

technical field [0001] The invention belongs to the field of medical technology and relates to a temperature-sensitive gel for intravenous injection, which has the advantages of no damage, simplicity and speed. Background technique [0002] Intraoperative bleeding is unavoidable in almost all surgical operations. With the development of science and technology and the emergence of some new hemostatic materials and equipment, the hemostatic technology in surgical operations has also undergone revolutionary development. Hemostasis is one of the cores of basic surgical techniques. Surgical operations on any part of the human body almost without exception involve bleeding and hemostasis. Hemostasis technology has developed from simple instrumental hemostasis measures in the past to a complex technical system under modern surgical conditions. , mainly including interventional hemostatic measures, physical and chemical hemostatic measures and external hemostatic drugs fibrin viscos...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/06A61L31/00A61L31/14
Inventor 姚静
Owner 江苏贝佳制药有限公司
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