Chlorhexidine and oligochitosan-containing pharmaceutical composition and applications thereof

A technology of chitosan oligosaccharides and chlorhexidine, which is applied in daily health care, disinfection and antibacterial fields, can solve problems such as poor stability of aqueous solutions, affecting compliance, and poor aqueous solution properties, and achieve the effect of reducing bitter taste

Active Publication Date: 2013-12-18
四川涑爽医疗用品股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although chlorhexidine and its salt have good bactericidal effect at the concentration of 0.2% or more, because chlorhexidine and its salt water solution are not good, its aqueous solution stability is poor, and chlorhexidine and its salt often c

Method used

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  • Chlorhexidine and oligochitosan-containing pharmaceutical composition and applications thereof
  • Chlorhexidine and oligochitosan-containing pharmaceutical composition and applications thereof
  • Chlorhexidine and oligochitosan-containing pharmaceutical composition and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1, composition containing chlorhexidine and chitosan oligosaccharide and preparation method thereof

[0032] Formula: Chlorhexidine Acetate 0.1g

[0033] Oligochitosan 0.5g

[0034] Glycerin 4g

[0035] Purified water was added to 100g.

[0036] Preparation method: Weigh 0.1g of chlorhexidine acetate in a container, add 90ml of purified water, stir, after the chlorhexidine acetate is fully dissolved, weigh 0.5g of chitosan oligosaccharide, add it to a beaker, stir, and wait for the chitosan oligosaccharide to dissolve After completion, add 4g of glycerin, continue to stir, add purified water to make the total amount reach 100g, continue to stir for 5 minutes, fully dissolve, check the pH, adjust the pH to 5.5-6.5 with hydrochloric acid or sodium hydroxide if necessary, and further use 1200 mesh stainless steel filter through a filter, and finally fill and seal. This product can be used as a disinfectant for the skin or the surface of ...

Embodiment 2

[0037] Embodiment 2, composition containing chlorhexidine and chitosan oligosaccharide and preparation method thereof

[0038] Formula: Chlorhexidine Gluconate 0.3g

[0039] Oligochitosan 0.5g

[0040] Purified water was added to 100g.

[0041] Preparation method: Weigh 0.3g of chlorhexidine gluconate in a container, add 90ml of purified water, stir, after the chlorhexidine gluconate is fully dissolved, weigh 0.5g of chitosan oligosaccharide, add it to a beaker, stir, and wait for the chitosan oligosaccharide After the sugar is fully dissolved, add purified water to make the total amount reach 100g, continue to stir for 5 minutes, dissolve fully, check the pH, adjust the pH to 5.5-6.5 with hydrochloric acid or sodium hydroxide if necessary, and further filter with a 1200-mesh stainless steel filter. Finally, fill it in a spray bottle, seal it, and get it. This product is suitable for the hygiene care of the indoor air environment, and it can kill the planktoni...

Embodiment 3

[0047] Embodiment 3, composition containing chlorhexidine and chitosan oligosaccharide and preparation method thereof

[0048] Formula: Chlorhexidine acetate or chlorhexidine gluconate 0.05g

[0049] Oligochitosan 0.5g

[0050] Glycerin 4g

[0051] Sucralose 0.01g

[0052] Water soluble menthol 0.2g

[0053] Purified water was added to 100g.

[0054] Preparation method: weigh 0.05g of chlorhexidine acetate or chlorhexidine gluconate in a container, add 90ml of purified water, stir, after the chlorhexidine is fully dissolved, weigh 0.5g of chitosan oligosaccharide, add it to a beaker, stir, After the chitosan oligosaccharide is fully dissolved, add glycerin, sucralose, and water-soluble menthol in turn, stir and mix well, then add purified water to make the total amount reach 100g, continue stirring to completely dissolve, check the pH, and use hydrochloric acid or hydrogen if necessary Sodium oxide adjusts...

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Abstract

The invention relates to a chlorhexidine and oligochitosan-containing pharmaceutical composition, wherein the mass proportion of the chlorhexidine to oligochitosan is (0.1-1):1, the chlorhexidine comprises chlorhexidine acetate, chlorhexidine gluconate, chlorhexidine hydrochloride or chlorhexidine citrate, and the molecular weight of the oligochitosan is less than 5,000. The invention further relates to an application of the pharmaceutical composition in preparing a skin or object surface sanitizer, an application of the pharmaceutical composition in preparing an air-atomizing sanitizer, an application of the pharmaceutical composition in preparing an oral cavity sanitizer, an application of the pharmaceutical composition in preparing a vaginal irrigation solution, or an application of the pharmaceutical composition in preparing vaginal gels. According to the chlorhexidine and oligochitosan-containing pharmaceutical composition, the oligochitosan plays a role in obviously improving the antibacterial action of the chlorhexidine.

Description

technical field [0001] The invention relates to the field of medical products, specifically, the invention relates to a composition comprising chlorhexidine and chitosan oligosaccharide, and its application in disinfection and antibacterial, especially in daily health care. Background technique [0002] Chlorhexidine is a kind of surfactant, which has a fairly strong broad-spectrum antibacterial effect and is effective against a variety of bacteria. It has an antibacterial effect at a low concentration and a bactericidal effect at a high concentration. The commonly used salts of chlorhexidine are: : Acetate (chlorhexidine acetate), hydrochloride (chlorhexidine hydrochloride), citrate (chlorhexidine citrate), gluconate sugar salt (chlorhexidine gluconate). Although chlorhexidine and its salt have good bactericidal effect at the concentration of 0.2% or more, because chlorhexidine and its salt water solution are not good, its aqueous solution stability is poor, and chlorhexidi...

Claims

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Application Information

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IPC IPC(8): A61K31/722A61K31/702A61K31/7016A61P31/04A01N47/44A01P1/00A61K31/155A01N43/16
Inventor 张耿元白东跃庄灵习王保红
Owner 四川涑爽医疗用品股份有限公司
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