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Vaginal dilation suppository for cervical cancer as well as preparation method and detection method thereof

A technology for vaginal expansion suppositories and detection methods, which are applied in the directions of suppository delivery, pharmaceutical formulations, and material inspection products, can solve problems such as difficult cleaning, difficult adhesion, poor stability of suppositories, etc., and achieve the effects of avoiding secondary infection and preventing outflow.

Active Publication Date: 2014-01-08
哈尔滨田美药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The curative effect of cervical tumor thrombus has been clinically confirmed for many years, but there are still some technical problems in itself. The matrix and Pinellia palmata extract in the cervical tumor thrombus disclosed in the "Ministry of Health Drug Standard Chinese Medicine Prescription" are not easy to bond and are easy to bind. Produce sediment, affect the stability of suppository, the absorption of described Pinellia palmata extract is poor, further affect the bioavailability and curative effect of suppository; The water-soluble matrix has very slight irritation to vaginal mucosa; CN1365693 discloses the Pinellia palmatum is nano-treated and then made into a suppository. The suppository solves the technical problems of incomplete absorption and low bioavailability of Pinellia palmatum. Very poor; and the tampons in the above-mentioned cervical cancer embolus have no swelling effect, or the swelling is disordered, which greatly reduces the clinical application; the suppository is easy to contaminate the clothes and is not easy to clean; the quality control method is unreliable, resulting in batch failure in the actual production process. The content, stability, and time limit of melting change between

Method used

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  • Vaginal dilation suppository for cervical cancer as well as preparation method and detection method thereof
  • Vaginal dilation suppository for cervical cancer as well as preparation method and detection method thereof
  • Vaginal dilation suppository for cervical cancer as well as preparation method and detection method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087]

[0088] Preparation:

[0089]1) Preparation of drug-containing matrix:

[0090] a. Polyethylene glycol 6000 and polyethylene glycol 400 are placed in a water bath and heated to melt to obtain a melt;

[0091] b. Preparation of traditional Chinese medicine extract: take the prescribed amount of Pinellia palmatum, crush it, add 70% ethanol to soak for 5 hours, and then extract it four times with 70% ethanol under reflux. 3h, the amount of ethanol added for the second time is 10 times of the weight of Pinellia palmatum, refluxed for 2h, the amount of ethanol added for the third time is 5 times of the weight of Pinellia palmatum, refluxed for 1.5h, the amount of ethanol added for the fourth time is 3 times of the weight of Pinellia palmatum , refluxed for 1.5h, combined the reflux liquid, filtered, the filtrate was concentrated to a clear paste with a relative density of 1.10 at a temperature of 70°C, added water twice the volume of the clear paste, allowed to settle, ...

Embodiment 2

[0095]

[0096] Preparation method: make 100 bullet-shaped suppositories according to the method described in Example 1, each weighing about 3.1g.

Embodiment 3

[0098]

[0099] Preparation:

[0100] 1) Preparation of drug-containing matrix:

[0101] a. place carboxymethylcellulose sodium in a water bath to heat and melt, add self-emulsifying monostearate under stirring, and mix evenly to obtain a melt;

[0102] b. Preparation of Chinese medicine extract:

[0103] Ⅰ. Weigh the prescription amount of Pinellia palmatum, crush it, add 70% ethanol to soak for 5 hours, and then use 70% ethanol to reflux and extract four times. The amount of ethanol is 10 times the weight of Pinellia palmatum, reflux for 2 hours, add ethanol for the third time to 5 times the weight of Pinellia palmatum, reflux for 1.5 hours, add ethanol for the fourth time 3 times the weight of Pinellia palmatum, reflux for 1.5 hours, and combine The reflux liquid is filtered, and the filtrate is concentrated to a clear paste with a temperature of 70°C and a relative density of 1.10, adding water twice the volume of the clear paste, allowing it to settle, and spray-dryi...

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PUM

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Abstract

The invention relates to a vaginal dilation suppository for cervical cancer as well as a preparation method and a detection method thereof. The vaginal dilation suppository comprises a Chinese medicine extract, a matrix and a dilation carrier, wherein a medicine-containing matrix formed by the Chinese medicine extract and the matrix is coated on the surface of the dilation carrier; the Chinese medicine extract comprises pinellia pedatisecta, centella and snake gourd fruit; the medicine-containing matrix also comprises powdered cellulose which can improve the stability of the vaginal dilation suppository for cervical cancer; cinnamyl alcohol and stearoyl hexadecanamide can synergistically promote the absorption of the Chinese medicine extract, and the bioavailability of the dilation suppository is improved; in addition, the vaginal dilation suppository for cervical cancer adopts six unique technologies and has the beneficial effects of preventing outflow of medicine liquor and preventing secondary infection, and is high in stability, durable in curative effect and the like.

Description

technical field [0001] The invention belongs to the field of vaginal suppositories, in particular to a vaginal expansion suppository for cervical cancer, a preparation method and a detection method thereof. Background technique [0002] Cervical tumor embolus, recorded in the fourth volume of "Ministry of Health Drug Standards Traditional Chinese Medicine Prescription Preparations", prepared from Pinellia palmata extract, polyethylene glycol 6000, polyethylene glycol 4000; cervical cancer embolism, has the effect of reducing swelling The effect of dispelling stagnation is clinically used for cervical cancer and precancerous lesions of the uterus. [0003] The curative effect of cervical tumor thrombus has been clinically confirmed for many years, but there are still some technical problems in itself. The matrix and Pinellia palmata extract in the cervical tumor thrombus disclosed in the "Ministry of Health Drug Standard Chinese Medicine Prescription" are not easy to bond and...

Claims

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Application Information

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IPC IPC(8): A61K36/8888A61K9/02A61P35/00A61P15/00G01N33/15G01N5/04
Inventor 邱学良邱明世
Owner 哈尔滨田美药业股份有限公司
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