Preparation method of traditional Chinese medicine tablet for treating osteoporosis

Abstract

The invention discloses a preparation method of a traditional Chinese medicine tablet for treating osteoporosis. The preparation method comprises the following steps of: milling radix clematidis, fructus psoraleae, eucommia ulmoides, dipsacus root, medlar, rhizoma anemarrhenae, achyranthes aspera, herba cistanche, oyster, Chinese angelica, cuscuta chinensis, asarum, caulis spatholobi, frankincense, fructus cnidii, and herba lycopi into 40-60-mesh fine powder, adding ethanol, the volume is 3-5 times that of the fine powder, for reflux extraction for 1-2 hours, filtering the resulting product, recycling the ethanol, concentrating the filtrate to thin cream, adding water into the decoction dreg for further decoction, concentrating the filtrated filtrate into thin cream, mixing the thin creams from the two times of concentration, concentrating the mixed thin cream to the thick cream at the density of 1.25-1.35, drying the thick cream to obtain a powder, adding 20-40 parts of starch, 15-25 parts of microcrystalline cellulose, 10-15 parts of hydroxy propyl cellulose, and 10-15 parts of mannitol into the obtained powder for uniform mixing, preparing the resulting mixture to a soft product by using proper 40-60% of ethanol, granulating the soft product by using a 18-20-mesh screen, drying the granulated product at 50-60 DEG C, straightening-granulating the dried product using a 16-18-mesh screen, adding 8-12 parts of hydroxy propyl cellulose, proper silicon dioxide, and proper magnesium stearate into the granulated product for uniform mixing, pressing the mixture for tabletting, and sugar-coating the tablet to obtain the traditional Chinese medicine tablet for treating the osteoporosis. The traditional Chinese medicine tablet has the efficacies of nourishing liver and kidney, tonifying essence and blood, consolidating the kidney and supplementing essence, and can be used for treating the osteoporosis.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, in particular to a preparation method of a traditional Chinese medicine tablet for treating osteoporosis. Background technique [0002] Osteoporosis is a systemic metabolic skeletal disease characterized by decreased bone mass and degeneration of bone microstructure, resulting in increased bone fragility and susceptibility to fractures. . As the world's population is aging, osteoporosis has become one of the most common geriatric diseases. Osteoporosis not only seriously threatens people's health, but also causes serious economic burden to families and society. [0003] There is no record of the name of osteoporosis in Chinese medical books of all dynasties, but the descriptions of the clinical symptoms such as bone fistula, bone numbness, and bone dryness are quite similar to osteoporosis. Most scholars believe that primary osteoporosis should belong to bone fistula. The theory o...

AI Technical Summary

Problems solved by technology

However, the research and development of anti-osteoporosis traditional Chinese medicine is still in its infancy, and there are few ready-made medicines that can be used clinically.

The mechanism of action of traditional Chinese medicine in the treatment of osteoporosis is not completely clear, and there are few research reports on its active ingredients

[0004] At present, calcium preparations, drugs that inhibit bone resorption, bisphosphonates, osteogenic drugs, and vitamin analogs that promote mineralization are generally used to treat osteoporosis clinically, but the calcium supplementation effect of these drugs is limited, and western About long-term use of drugs will increase the burden on the liver and kidneys, especially contraindicated for pregnant women