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Traditional Chinese medicine composition of total flavonoids of sea-buckthorn and linoleic acid and preparation method of composition

A technology of total flavonoid linoleic acid and total flavonoids of sea buckthorn is applied in the directions of drug combination, pharmaceutical formula, plant raw material, etc., to achieve the effect of good curative effect, high purity and small dosage

Inactive Publication Date: 2014-01-15
TIANJIN TIANSHI BIOLOGICAL DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no drug that utilizes the mechanism of linoleic acid and cholesterol metabolism to treat cardiovascular diseases

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] Take the seabuckthorn medicinal material, crush it, add ethyl acetate and 70% ethanol with a volume ratio of 1:2, heat and extract twice, the first time for 1 hour, and the second time for 1 hour, the filtrates are combined to obtain the extract I, and the dregs are added 70% ethanol, heated and refluxed for 2 times, 0.5 hours for the first time, 0.5 hours for the second time, the filtrates were combined to obtain the extract II, the combined extracts I and II were concentrated into extracts, and the extracts were dissolved with 50% ethanol. The macroporous resin AB-8 is used to separate it, first eluting with water to obtain eluent I; then eluting with 50% ethanol, and then eluting with 90% ethanol, and the elution flow rate is 1BV / h to obtain eluent I Liquid II was recovered, concentrated under reduced pressure, and dried to obtain the total flavonoids extract of Hippophae rhamnoides. After testing, the purity of total flavonoids from seabuckthorn can reach 24.19%.

...

Embodiment 2

[0080] Take the seabuckthorn medicinal material, grind it, add ethyl acetate and 70% ethanol with a volume ratio of 1:2, heat and extract twice, the first time is 3 hours, the second time is 2 hours, the filtrates are combined to obtain the extract I, and the dregs are added 70% ethanol, heated and refluxed for 2 extractions, the first time was 1.5 hours, the second time was 1 hour, the filtrates were combined to obtain the extract II, the combined extracts I and II were concentrated into extracts, and the extracts were dissolved with 50% ethanol. Macroporous resin X-5 was used to separate it, firstly eluted with water to obtain eluent I; then eluted with 60% ethanol, and then eluted with 95% ethanol, and the elution flow rate was 4BV / h to obtain eluent I Liquid II was recovered, concentrated under reduced pressure, and dried to obtain the total flavonoids extract of Hippophae rhamnoides. After testing, the purity of total flavonoids from seabuckthorn can reach 25.39%.

[008...

Embodiment 3

[0083] Take the seabuckthorn medicinal material, crush it, add ethyl acetate and 70% ethanol with a volume ratio of 1:2, heat and extract twice, the first time is 1.5 hours, the second time is 1.5 hours, the filtrates are combined to obtain the extract I, and the dregs are added 70% ethanol, heated and refluxed for 2 extractions, the first time for 1 hour, the second time for 1 hour, the filtrates were combined to obtain the extract II, the combined extracts I and II were concentrated into extracts, and the extracts were dissolved with 50% ethanol. The macroporous resin AB-8 is used to separate it, and first eluted with water to obtain eluent I; then eluted with 55% ethanol, and then eluted with 95% ethanol, and the elution flow rate is 3BV / h to obtain eluent I Liquid II was recovered, concentrated under reduced pressure, and dried to obtain the total flavonoids extract of Hippophae rhamnoides. After testing, the purity of total flavonoids from seabuckthorn can reach 24.95%. ...

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PUM

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Abstract

The invention discloses a traditional Chinese medicine composition of total flavonoids of sea-buckthorn and linoleic acid. The composition comprises the following components by weight percent: 20-80% of total flavonoids of sea-buckthorn and 20-80% of linoleic acid. The invention also discloses a preparation method of the traditional Chinese medicine composition. The preparation method comprises the steps of extracting the total flavonoids of sea-buckthorn and preparing the finished product according to the formula. The traditional Chinese medicine composition makes the best of the treatment effects of the total flavonoids of the sea-buckthorn on cardiovascular diseases as well as the mechanism of metabolism between linoleic acid and cholesterol, adopts scientific matching, generates synergistic effects, has better curative effects and more controllable quality than traditional preparations of extracts of total flavonoids of sea-buckthorn and is suitable for industrial production.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating cardiovascular diseases and a preparation method thereof, belonging to the field of traditional Chinese medicines. Background technique [0002] With the continuous improvement of people's living standards, changes in diet structure, population aging is becoming more and more obvious, and the incidence of coronary heart disease is increasing day by day. Coronary heart disease is a heart disease caused by narrowing of the lumen caused by coronary atherosclerosis, which causes myocardial blood supply and oxygen supply disturbance, and is known as the "world killer". As far as the whole world is concerned, coronary heart disease has become one of the most serious diseases threatening human health in the past half century, and it is the main cause of death in the United States and some industrialized countries. According to the statistics of the World Health Organization, 24....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P9/00A61P3/06A61P9/10A61K31/201
Inventor 崔卜东贾林
Owner TIANJIN TIANSHI BIOLOGICAL DEV
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