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Traditional Chinese medicine granules having effects of harmonizing liver and spleen, resisting inflammation and alleviating pains and preparation method thereof
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An anti-inflammatory and analgesic technology, traditional Chinese medicine granules, applied in anti-inflammatory agents, non-central analgesics, medical preparations containing active ingredients, etc., can solve problems such as toxic and side effects
Inactive Publication Date: 2014-08-06
抚顺致诚市场营销策划有限公司
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[0004] At present, there are few chemical drugs or health products in the treatment of liver and spleen, anti-inflammatory and pain-relieving symptoms, and all of them have different degrees of toxic and side effects, such as gastrointestinal irritation, renal function damage, etc., and may cause related complications
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Embodiment 1
[0127] A traditional Chinese medicine granule with functions of harmonizing liver and spleen, anti-inflammatory and analgesic, which is prepared by the following method:
[0128] (1) Weigh the raw material medicine (stir-fried white peony root with vinegar bran-honeyed licorice 3:2) in proportion, and mix them;
[0129] (2) Add 5 times the weight of water-saturated n-butanol-75% ethanol mixed solvent (2:1) to the crude drug, extract twice, each time for 2 hours, filter, combine the filtrates, and concentrate to 0.2g crude drug / ml;
[0130] (3) Put the filtrate on NKA-9 macroporous resin column, elute with 80% ethanol, and collect the eluate;
[0131] (4) Add 0.1% activated carbon and 0.1% EDTA to the eluent by weight to remove pigment and heavy metals, filter, and concentrate the filtrate to obtain a concentrate;
[0132] (5) Put the cyclodextrin-sucrose (1:1) mixture into the fluidized bed, send it into the hot air for preheating, and when the temperature reaches 35°C, spr...
Embodiment 2
[0135] (1) Weigh the raw material medicine (stir-fried white peony root with vinegar bran-honeyed licorice 3:2) in proportion, and mix them;
[0136] (2) Add 6 times the weight of water-saturated n-butanol-75% ethanol mixed solvent (2:1) to the crude drug, extract twice, each time for 1 hour, filter, combine the filtrates, and concentrate to 0.15g crude drug / ml;
[0137] (3) Put the filtrate on NKA-9 macroporous resin column, elute with 80% ethanol, and collect the eluate;
[0138] (4) Add 0.1% activated carbon and 0.1% EDTA to the eluent by weight to remove pigment and heavy metals, filter, and concentrate the filtrate to obtain a concentrate;
[0139] (5) Put the cyclodextrin-sucrose (1:1) mixture into the fluidized bed, send it into the hot air for preheating, and when the temperature reaches 40°C, spray the concentrated solution of step (4) and 2% hypromellose Base cellulose solution to complete the spray granulation step; wherein, the temperature of the air inlet is 70...
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Abstract
The present invention relates to traditional Chinese medicine granules having effects of harmonizing liver and spleen, resisting inflammation and alleviating pains. The traditional Chinese medicine granules comprise the raw materials: 3 parts by weight of white peony root stir-fried with vinegar and bran, and 2 parts by weight of honey moistened licorice root. The invention also provides a preparation method of the traditional Chinese medicine granules. The traditional Chinese medicine granules prepared by the method have outstanding effects of harmonizing liver and spleen, resisting inflammation and alleviating pains. Pharmacology experiments and clinical application results show that the granules have liver protective effect, digestive system inflammation resisting effect, and emergency relieving and pains alleviating effect and other efficacies. In addition, because of selection of the specific processed products and the specific proportion of the raw materials and with addition of improvement of the refining method, the granules have simple and feasible whole method and low cost, and are more suitable for industrialized mass production; and moreover, the granules have the advantages of convenient taking and good taste because of retention of more active ingredients.
Description
technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine granule with functions of harmonizing liver and spleen, anti-inflammatory and analgesic and a preparation method thereof. Background technique [0002] Liver-spleen disharmony syndrome is a disease caused by dysfunction of the liver, dysfunction of the spleen, imbalance of the relationship between the two viscera, and dysfunction. It is mostly caused by emotional failure, long-term depression and liver damage, or eating disorders, fatigue and spleen damage. The clinical manifestations of liver-spleen disharmony are: fullness or pain in the chest and hypochondrium, sudden desire to breathe heavily, emotional depression or irritability, loss of appetite, abdominal distension and loose stools, or episodic abdominal pain and diarrhea, white or greasy tongue coating, stringy pulse . Distension and pain in the chest and hypochondr...
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