Method for engraving (three-dimensional) bionic artificial bones in compound bioactive material microdomains

Abstract

The invention provides a method for engraving (three-dimensional) bionic artificial bones in compound bioactive material microdomains. The method comprises the following steps: selecting orthopedics department hard biological materials and active cell tissues for growing support materials, carrying out bionics matching, and carrying out 3DMAX creation and 3D printing by adopting computer three-dimensional design, thus realizing the simulation of artificial bone materials and structures; establishing an artificial bone microcirculation structure and a blood perfusion condition; establishing osteogenesis stem cells growing environments, namely a capillary bed and a biological activity support. The capillary bed and the biological activity support manufactured by adopting the method have the advantages that the initiative response of hard materials (transplanted bones) and host bones is established, the problem of the initiative fusion between currently various biological materials comprising artificial bone materials of allogeneic bones and the host bones is solved, the clinical indication range of bone transplantation is widened, the secondary replacement of artificial joints can be avoided, and the application ranges of the artificial bones and the artificial joints can be widened.

Description

technical field [0001] The invention relates to the technical field of biological tissue engineering regenerative repair medicine, in particular to a method for micro-area engraving of bionic artificial bone with composite bioactive materials, and a third-generation method for repairing bone defects with biologically hard materials. Background technique [0002] 1. Bone graft products [0003] Traditional hard tissue (bones, teeth, etc.) repair materials, such as: artificial bone substitute materials, artificial joint prosthesis, dental implants, etc., are quite different from human bone tissue in composition and structure, and the bone tissue after implantation The repair process is basically a passive "filling" process, and the degradation rate of the material does not match the rate of new bone formation. The time gap between the host bone of the transplanted recipient and the graft material appears, making it difficult to achieve true "biological fusion". , non-union or...

AI Technical Summary

Problems solved by technology

This method not only establishes the active response between the hard material (grafted bone) and the host bone, solves the problem of active fusion between various biomaterials including allograft bone materials and the host bone, but also improves the clinical adaptability of bone grafting. disease range, and can avoid artificial joint replacement and broaden the application space of artificial bone and artificial joint

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