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A thin-layer differential chromatography method for Jianweiyuyang preparation

A technique of thin-layer identification and chromatographic method is applied in the field of quality control of Jianweiyuyang preparations, which can solve the problems of cumbersome, labor-intensive, material resources, time, complex identification process, etc., to ensure safety and effectiveness, and save labor. , the effect of improving the level of quality control

Active Publication Date: 2016-01-20
JIUZHITANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Both Jianweiyuyang Tablets and Jianweiyuyang Granules are included in the 2010 edition of "Chinese Pharmacopoeia", and there are 5 TLC identification items in the TLC identification method recorded in it (Bupleurum, Codonopsis, Paeoniflorin, Corydalis, Qingdai) The test items need to be processed separately, unfolded-colored-inspected separately to control the quality. The identification process is complicated and cumbersome, and consumes a lot of manpower, material resources and time

Method used

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  • A thin-layer differential chromatography method for Jianweiyuyang preparation
  • A thin-layer differential chromatography method for Jianweiyuyang preparation
  • A thin-layer differential chromatography method for Jianweiyuyang preparation

Examples

Experimental program
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Effect test

Embodiment 1

[0025] (1) Take 1.5g of Jianweiyuyang tablet, grind it finely, add 40ml of methanol, ultrasonicate for 40 minutes, let cool, filter, evaporate the filtrate to dryness, add 20ml of water to the residue, heat to dissolve, shake with n-butanol saturated with water Extract 2 times, 30ml each time, combine the n-butanol solution, evaporate to dryness, add 1ml methanol to the residue to dissolve, and use it as the test solution. Take another 0.5g of Bupleurum reference medicinal material, add 100ml of water, decoct for 1 hour, let cool, filter, evaporate the filtrate to dryness, add 40ml of methanol, treat with ultrasound for 40 minutes, let cool, filter, evaporate the filtrate to dryness, add 20ml of water to the residue, Heat to dissolve, shake and extract twice with water-saturated n-butanol, 30ml each time, combine the n-butanol liquid, evaporate to dryness, add 1ml methanol to the residue to dissolve, and use it as the Bupleurum reference medicinal solution. Take 0.5 g of licor...

Embodiment 2

[0030] (1) Take 5g of Jianweiyuyang granule, grind it finely, add 30ml of methanol, ultrasonicate for 60 minutes, let cool, filter, evaporate the filtrate to dryness, add 10ml of water to the residue, heat to dissolve, shake and extract with n-butanol saturated with water 2 times, 15ml each time, combined n-butanol solution, evaporated to dryness, added 0.5ml of methanol to dissolve the residue, and used it as the test solution. Take another 0.2g of Bupleurum reference medicinal material, add 50ml of water, decoct for 0.5 hours, let cool, filter, evaporate the filtrate to dryness, add 30ml of methanol, ultrasonicate for 60 minutes, let cool, filter, evaporate the filtrate to dryness, add 10ml of water to the residue, Heat to dissolve, shake and extract twice with water-saturated n-butanol, 15ml each time, combine the n-butanol solution, evaporate to dryness, add 0.5ml methanol to the residue to dissolve, and use it as the Bupleurum reference medicinal material solution. Take 0...

Embodiment 3

[0035] (1) Take 10g of Jianweiyuyang Capsules, grind them finely, add 100ml of methanol, ultrasonically treat for 15 minutes, let cool, filter, evaporate the filtrate to dryness, add 10ml of water to the residue, heat to dissolve, shake and extract with n-butanol saturated with water 2 times, 50ml each time, combined n-butanol solution, evaporated to dryness, added 2ml of methanol to dissolve the residue, and used it as the test solution. Take another 1.0g of Bupleurum reference medicinal material, add 250ml of water, decoct for 2 hours, let cool, filter, evaporate the filtrate to dryness, add 100ml of methanol, treat with ultrasound for 15 minutes, let cool, filter, evaporate the filtrate to dryness, add 10ml of water to the residue, Heat to dissolve, shake and extract twice with water-saturated n-butanol, 50ml each time, combine the n-butanol solution, evaporate to dryness, add 2ml methanol to the residue to dissolve, and use it as the Bupleurum bupleurum reference drug solut...

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Abstract

The invention discloses a thin-layer identification chromatography method of a stomach-strengthening ulcer-curing preparation, and changes the thin-layer identification method of radix bupleuri, corydalis tuber and natural indigo in a stomach-strengthening ulcer-curing tablet, and thin-layer identification of licorice is added. Five thin-layer identification items in the current ''Chinese pharmacopoeia'' need respective test sample processing and respective developing-coloration-viewing for quality control, and are complicated and cumbersome. According to the thin-layer identification chromatography method of the invention, six thin-layer identification items share a test sample solution below a [identification] (2) item in the ''Chinese pharmacopoeia'', and are performed by four developing-coloration-viewing processes, manpower, material resources and time are saved, and the thin-layer identification of the licorice is added. The improved thin-layer identification chromatography method of the invention improves the quality control level of drugs, and ensures the safety and effectiveness of the use of the drugs. The thin-layer identification chromatography method of the stomach-strengthening ulcer-curing preparation can be used for the control of the quality of the stomach-strengthening ulcer-curing tablet, and can be used for control of the quality of capsules, granules and other dosage forms of the same prescription.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a quality control method of Jianweiyuyang preparation. Background technique [0002] Both Jianweiyuyang Tablets and Jianweiyuyang Granules are included in the 2010 edition of "Chinese Pharmacopoeia", and there are 5 TLC identification items in the TLC identification method recorded in it (Bupleurum, Codonopsis, Paeoniflorin, Corydalis, Qingdai) The test items need to be processed separately, unfolded-color developed-inspected separately to control the quality. The identification process is complicated and cumbersome, and consumes a lot of manpower, material resources and time. Contents of the invention [0003] The purpose of the present invention is to provide a thin-layer differential chromatography method for Jianweiyuyang preparations. The test solution only needs to be uniformly prepared by the same method, and there is no need to separatel...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/90
Inventor 辛秀谷陟欣张妮瑜袁莉任洁芳朱丽欧金秀刘淑妦熊海霞
Owner JIUZHITANG
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