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Recycling method of edible grade oil in the process of biotransformation to produce androstenedione

A technology of androstenedione and biotransformation, applied in the direction of organic chemistry, steroids, etc., can solve the problems of environmental pollution, waste of vegetable oil resources, etc., and achieve the effects of protecting the environment, reducing the heating time, and shortening the process.

Active Publication Date: 2017-12-01
SHANGHAI PESTICIDE RES INST +1
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

If it is discarded, it will not only pollute the environment, but also cause a great waste of vegetable oil resources and the risk of returning to the dining table

Method used

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  • Recycling method of edible grade oil in the process of biotransformation to produce androstenedione

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Experimental program
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Embodiment 1

[0025] Material source: The biotransformation reaction liquid of androstenedione in the upper section adopts a two-liquid-solid-solid four-phase process, and the obtained biotransformation reaction liquid is a liquid-liquid-solid-solid four-phase system, and the liquid phases are water phase and The oil phase (food grade vegetable oil), the solid phase are the cells and the medium containing the product respectively. The vegetable oil can be corn oil, rapeseed oil, sunflower oil, soybean oil, peanut oil, salad oil, edible blending oil, etc.

[0026] The separation process steps are as follows

[0027] Step 1: Place the liquid-liquid-solid-solid four-phase system in the washing tank and settle naturally. Temperature, 10°C, settling time: about 10 hours.

[0028] Step 2: Open the discharge valve at the bottom of the washing tank, discard the heavy water phase to the three waste collection pool, the liquid-solid-solid three-phase feed liquid left in the washing tank; the liquid...

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Abstract

The invention belongs to the field of chemical engineering and process technology. The androstenedione reaction liquid generated by biotransformation is used as a raw material, a decanter centrifuge is coupled with a scraper evaporator, and the above-mentioned The food-grade oil in the reaction solution is separated to achieve the purpose of recycling and reuse. The above-mentioned means can reduce the heating time of the food-grade oil in the separation process, reduce the change of the physical properties of the food-grade oil in the separation process, and greatly reduce the production of androstenedione. The cost of raw materials is reduced, and the waste emission of edible-grade oil is reduced by 75%. Reduce waste of resources, protect the environment, and realize a clean production process for the biotransformation of steroid compounds.

Description

technical field [0001] The invention belongs to the technical field of chemical engineering and technology, and specifically relates to a method for recycling and reusing edible-grade oil in the production of pharmaceutical intermediate androstenedione through biotransformation. Background technique [0002] Androstenedione (Androstenedione) is referred to as AD; chemical name: 4-androstenedione-3,17-dione; [CAS number]: 63-05-8, is the production of adrenocortical hormone drugs including diuretic spironolactone (alias : important intermediate of spironolactone, spironolactone sterol). [0003] Using phytosterols that are abundant in nature as raw materials, the method of selectively cutting the side chains of sterols and converting them into AD through microbial fermentation technology is called biotransformation. This process has become a development trend because of its high yield and low pollution. [0004] The transformation of sterols by microorganisms is generally d...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07J1/00
Inventor 姚再男薛建萍唐璐敏朱健徐玉华李还宝卜桂琴胡月明杨彬
Owner SHANGHAI PESTICIDE RES INST
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