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A preparation method of Yikang Buyuan Tablet and its application in drugs for inhibiting mouse lymphoma cell yac-1 cell proliferation

A technology of lymphoma cells and YAC-1, which is applied in the field of traditional Chinese medicine, can solve the problems of large dosage for patients, rough process, and influence on application, and achieve the effect of reducing dosage, no bitterness in dosage, and small dosage

Active Publication Date: 2015-08-19
烟台力量知识产权服务有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical and microwave technology in the extraction and preparation of Yikang Buyuan Granules. However, the method of extracting volatile oil and decocting in water is rough and backward in process and has many impurities, which leads to excessive dosage for patients and is inconvenient. Taking it seriously affects the clinical application of this product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Take 280g of Astragalus, 80g of Mahan, 190g of Angelica, 220g of Eclipta, 190g of Atractylodes, 150g of Safflower, 140g of Radix Paeoniae Rubra, 140g of peach kernel, 150g of Achyranthes bidentata, 120g of Chuanxiong, 70g of Citrus aurantium, 100g of Campanulaceae, combine Mahan, Angelica, Cangzhu, peach kernel, and Chuanxiong were added to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer to the total extraction solvent is 5%, the extraction pressure is 25MPa, the temperature is 40°C, and the CO 2 The flow rate is 2ml / g crude drug·min, the extraction time is 200min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, pulverized, added 1.6L of 50% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 700W, and the extraction is performed twice. , 8 minutes each time, combine the extracts, concentrate, add to...

Embodiment 2

[0034] Take 280g of Astragalus, 80g of Mahan, 190g of Angelica, 220g of Eclipta, 190g of Atractylodes, 150g of Safflower, 140g of Radix Paeoniae Rubra, 140g of peach kernel, 150g of Achyranthes bidentata, 120g of Chuanxiong, 70g of Citrus aurantium, 100g of Campanulaceae, combine Mahan, Angelica, Cangzhu, peach kernel, and Chuanxiong were added to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 4%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3ml / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, pulverized, added 1.6L of 50% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 600W, and the extraction is performed twice. , 5 minutes each time, combine the extracts, concentrate, add to...

Embodiment 3

[0037] Take 280g of Astragalus, 80g of Mahan, 190g of Angelica, 220g of Eclipta, 190g of Atractylodes, 150g of Safflower, 140g of Radix Paeoniae Rubra, 140g of peach kernel, 150g of Achyranthes bidentata, 120g of Chuanxiong, 70g of Citrus aurantium, 100g of Campanulaceae, combine Mahan, Angelica, Cangzhu, peach kernel, and Chuanxiong were added to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer to the total extraction solvent is 6%, the extraction pressure is 15MPa, the temperature is 30°C, and the CO 2The flow rate is 1ml / g crude drug·min, the extraction time is 220min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, pulverized, added 1.6L of 50% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 800W, and the extraction is performed twice. , 10 minutes each time, combine the extracts, concentrate, add to...

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Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly provides a preparation method and application of a Yikangbuyuan tablet. The Yikangbuyuan tablet is prepared from 280g of radix astragali, 80g of Michelia hedyosperma Lew, 190g of angelica, 220g of yerbadetajo, 190g of rhizoma atractylodis, 150g of safflower, 140g of red paeonia, 140g of peach kernel, 150g of radix achyranthis bidentatae, 120g of hemlock parsley, 70g of fructus aurantii and 100g of balloonflower by supercritical extraction and microwave extraction, so that the penoniflorin content is greatly enhanced. The invention also provides application of the Yikangbuyuan tablet in preparing medicines for inhibiting mouse lymphomata cell YAC-1 proliferation.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a preparation method of Yikangbuyuan Tablet and its application in medicines for inhibiting mouse lymphoma cell YAC-1 cell proliferation. Background technique [0002] The standard number of Yikang Buyuan Granules is WS-10983 (ZD-0983)-2002, which is recorded in the Spleen and Stomach Subvolume of the National Compilation of Chinese Patent Standards. 280g Astragalus, 80g Mahan, 190g Angelica, 220g Eclipta, 190g Atractylodes, 150g safflower, 140g Radix Paeoniae Rubra, 140g peach kernel, 150g Achyranthes bidentata, 120g Chuanxiong, 70g Citrus aurantium, 100g Campanulaceae as raw materials, with Invigorating qi and activating blood circulation, invigorating the spleen and tonifying the kidney. For qi deficiency and blood stasis, spleen and kidney deficiency caused by fatigue, shortness of breath, insomnia, soreness of the waist and knees, lack of f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/752A61K9/20A61P35/00
Inventor 任立杰王璇刘海妮
Owner 烟台力量知识产权服务有限公司
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