Philinopside E, a novel antineoplastic compound in pentacta quadrangulasis

A technology of anti-tumor drugs and compounds, applied in the field of medicine

Inactive Publication Date: 2005-07-06
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The chemical structure and antitumor activity of the contained saponins have not been reported so far

Method used

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  • Philinopside E, a novel antineoplastic compound in pentacta quadrangulasis
  • Philinopside E, a novel antineoplastic compound in pentacta quadrangulasis
  • Philinopside E, a novel antineoplastic compound in pentacta quadrangulasis

Examples

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Embodiment Construction

[0120] The following examples further describe the separation and preparation of Philinopside E.

[0121] Choose 60kg of fresh square-column pentagonal ginseng grown in the sea area of ​​Zhanjiang, Guangdong Province, China, wash and remove the internal organs, and then air-dry naturally. The dried body wall is taken, pulverized, soaked and extracted with 5 times the amount (weight) of 85% ethanol at room temperature for 7 days. Filter out the ethanol extract, recover the ethanol under reduced pressure, and then extract it several times with n-butanol (50 L), and extract the n-butanol extract with petroleum ether (5 L), chloroform (5 L) and diethyl ether (5 L) successively to obtain a stream. extract. The liquid extract was dissolved in 3 times the weight of water, filtered, and the filtrate was passed through a D101 macroporous resin column, and eluted with water and 80% ethanol in turn. The 80% ethanol eluate was collected, and the solvent was recovered under reduced press...

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Abstract

The invention relates to medicinal technical field, and specifically to an antineoplastic compound Philinopside E with the molecular formula C53H81O24NaS separated from a square column pentangular cucumaria. The chemical constitution and spatial configuration of the compound are determined. The compound has an obvious inhibitory action to cell strains of 9 kinds of tumors such as HL-60 human leukemia and P-388 mouse lymphoma. The compound has an obvious inhibitory action to the nascent blood vessel genesis of tumor.

Description

technical field [0001] The invention relates to the technical field of medicine, and is a new anti-tumor compound Philinopside E isolated from marine animal quinquefolium ginseng. Background technique [0002] Pentacta quadrangulasis Lesson (Pentacta quadrangulasis Lesson) is widely distributed in the waters of Guangdong and Fujian in my country, and is an echinoderm of the family Cucurbitaceae. Body wall red, about 5-10cm long, with spinous processes on the back. It mostly grows in the intertidal zone or shallow sea stone bottom along the coast, and is widely distributed in the coastal areas of Guangdong and Fujian in my country. Folk used to treat stomach problems. The chemical structure and antitumor activity of the contained saponins have not been reported so far. Contents of the invention [0003] The present invention is a kind of new saponin compound extracted and separated from the square pillar pentagonal ginseng growing in the sea area of ​​Zhanjiang, Guangdon...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P35/00C07J71/00
Inventor 易杨华丁健张诗龙田芳李玲章雄文刘宝姝陈奕
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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