Preparation method and application of up-converted nano particle and graphene oxide composite material

A technology of nanoparticles and composite materials, which is applied in the field of preparation of fluorescent probe nanomaterials to achieve good water solubility

Inactive Publication Date: 2014-04-02
TIANJIN NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to intralamellar sp 3 district and sp 2 The random distribution of regions, GO exhibits peculiar electrical and optical properties, and is considered to be a functionalized graphene

Method used

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  • Preparation method and application of up-converted nano particle and graphene oxide composite material
  • Preparation method and application of up-converted nano particle and graphene oxide composite material
  • Preparation method and application of up-converted nano particle and graphene oxide composite material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] 1) Preparation of water-soluble folic acid-functionalized upconversion particles:

[0052] a) Preparation of rare earth nitrates: 0.4 mmol yttrium oxide Y 2 o 3 , 0.09mmol ytterbium oxide Yb 2 o 3 , 0.01mmol erbium oxide Er 2 o 3 , that is, the ratio of the amount of yttrium, ytterbium, and erbium Y / Yb / Er = 80 / 18 / 2, Y+Yb+Er=1mmol, weigh the mass, put it into a 50mL small beaker, add 1.5mL concentrated nitric acid, 4mL High-purity water, nitrated at 100oC in a fume hood, evaporated to dryness; among them, Yttrium oxide Y 2 o 3 The amount of Y in the substance is 0.8mmol, ytterbium oxide Yb 2 o 3 The amount of substance in Yb is 0.18mmol, erbium oxide Er 2 o 3 The amount of substance in Er is 0.02mmol;

[0053] b) Preparation of diethylene glycol-modified upconversion particles: Weigh 4mmol NaF, put it in a 100mL round bottom flask, add 2mL diethylene glycol + 8mL high-purity water, and heat it to 160oC with an oil bath under nitrogen protection and magneti...

Embodiment 2

[0062] 1) Preparation of water-soluble folic acid-functionalized upconversion particles:

[0063] a) Preparation of rare earth nitrates: 0.4 mmol yttrium oxide Y 2 o 3 , 0.09mmol ytterbium oxide Yb 2 o 3 , 0.01mmol erbium oxide Er 2 o 3 , that is, the ratio of the amount of yttrium, ytterbium, and erbium Y / Yb / Er = 80 / 18 / 2, Y+Yb+Er=1mmol, weigh the mass, put it into a 50mL small beaker, add 3mL concentrated nitric acid, 4mL high-purity water , in a fume hood at 100oC, nitrify and evaporate to dryness; where Yttria Y 2 o 3 The amount of Y in the substance is 0.8mmol, ytterbium oxide Yb 2 o 3 The amount of substance in Yb is 0.18mmol, erbium oxide Er 2 o 3 The amount of substance in Er is 0.02mmol;

[0064] b) Preparation of diethylene glycol-modified upconversion particles: Weigh 4mmol of NaF, put it in a 100mL round-bottomed flask, add 10mL of diethylene glycol, and heat it to 200oC with an oil bath under nitrogen protection and magnetic stirring. Add 12.5mL die...

Embodiment 3

[0073] 1) Preparation of water-soluble folic acid-functionalized upconversion particles:

[0074] a) Preparation of rare earth nitrates: 0.4 mmol yttrium oxide Y 2 o 3 , 0.09mmol ytterbium oxide Yb 2 o 3 , 0.01mmol erbium oxide Er 2 o 3 , that is, the ratio of the amount of yttrium, ytterbium, and erbium Y / Yb / Er=80 / 18 / 2, Y+Yb+Er=1mmol, weigh the mass, put it into a 50mL small beaker, add 2mL concentrated nitric acid, 4mL high-purity water , in a fume hood at 100oC, nitrify and evaporate to dryness; where Yttria Y 2 o 3 The amount of Y in the substance is 0.8mmol, ytterbium oxide Yb 2 o 3 The amount of substance in Yb is 0.18mmol, erbium oxide Er 2 o 3 The amount of substance in Er is 0.02mmol;

[0075] b) Preparation of diethylene glycol-modified upconversion particles: Weigh 4mmol NaF, put it in a 100mL round bottom flask, add 2mL diethylene glycol + 8mL high-purity water, and heat it to 160- 200oC, add 2.5mL diethylene glycol + 10mL high-purity water to the s...

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Abstract

The invention discloses a preparation method of a composite material of water-soluble folic acid-functionalized up-converted nano particles (FA-UCNPs) and graphene oxide (GO). The preparation method mainly comprises the three steps of preparing FA-UCNPs, namely firstly, synthesizing diethylene glycol-modified up-converted nano particles (DEG-UCNPs), and secondly, synthesizing the FA-UCNPs; preparing GO, namely firstly, preliminarily oxidizing a graphite sheet, oxidizing, and synthesizing the GO which is good in water solubility, high in yield and adjustable in size; and preparing FA-UCNPs/GO, namely dispersing FA-UCNPs and GO with a weight ratio being 1/1-1/2, vibrating for 10min, and drying under the normal temperature in a vacuum condition, so as to obtain the FA-UCNPs/GO. The FA-UCNPs/GO prepared by adopting the method is good in water solubility and stability and can be used for identifying canceration cells as a biological probe, so that the composite material is very good in application prospect for early diagnosing of cancers.

Description

[0001] This patent is supported by the National Natural Science Foundation of China General Project 21375095, National Excellent Doctoral Dissertation Author Special Fund FANEDD-201023, Tianjin Applied Basic Research Program Key Project 12JCZDJC21700, Tianjin Universities "Young and Middle-aged Backbone Innovative Talents Training Program" ZX110GG015 and Tianjin Supported by the "Bohai Scholars" Project of Talent Introduction 5RL098 of Normal University. technical field [0002] The invention belongs to the field of preparation of fluorescent probe nanomaterials, in particular to a composite material of water-soluble folic acid-functionalized upconversion nanoparticles and graphene oxide and a preparation method thereof, which is mainly used for identifying cancerous cells. Background technique [0003] Rare earth ions have rich energy level structures and excellent optical properties. In recent years, rare earth doped upconversion nanomaterials have shown important applicati...

Claims

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Application Information

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IPC IPC(8): G01N21/64
Inventor 李妍胡悦立靳晴孙玉秀陈晓芳
Owner TIANJIN NORMAL UNIVERSITY
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