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Near infrared photo-thermal conversion agent for tumor photo-thermal excision treatment

A near-infrared light and heat conversion technology, which is applied in the directions of antitumor drugs, medical preparations containing active ingredients, and pharmaceutical formulas, and achieves the effects of simple preparation, easy surface modification and low price.

Inactive Publication Date: 2014-04-16
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, the development of Prussian blue as a near-infrared photothermal conversion agent and its application in photothermal ablation therapy of tumors has not been reported.

Method used

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  • Near infrared photo-thermal conversion agent for tumor photo-thermal excision treatment
  • Near infrared photo-thermal conversion agent for tumor photo-thermal excision treatment
  • Near infrared photo-thermal conversion agent for tumor photo-thermal excision treatment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] A. Citric acid and ferric chloride (FeCl 3 ) Preparation of mixed solution

[0047] A certain amount of citric acid and FeCl 3 The aqueous solution is mixed so that the final concentration of citric acid is 0.025M, and FeCl 3 The concentration is 0.05M.

[0048] B. Citric acid and potassium ferrocyanide (K 4 [Fe(CN) 6 ]) Preparation of mixed solution

[0049] A certain amount of citric acid and K 4 [Fe(CN) 6 ] aqueous solution to make the final concentration of citric acid 0.025M, and make K 4 [Fe(CN) 6 ] at a concentration of 0.05M.

[0050] C. Synthesis of Prussian Blue Nanoparticles

[0051] Heat the mixed solution prepared in steps A and B to 60°C respectively, then add the mixed solution prepared in step B dropwise to the mixed solution prepared in step A at 60°C with stirring, the stirring speed is 500rpm / min, the dropping speed It is 0.8mL / min. After the dropwise addition was completed, the reaction was stirred at 60° C. for 30 min, and then cooled to...

Embodiment 2

[0056] A. Citric acid and ferric chloride (FeCl 3 ) Preparation of mixed solution

[0057] A certain amount of citric acid and FeCl 3 The aqueous solution is mixed so that the final concentration of citric acid is 0.25M, and FeCl 3 The concentration is 0.05M.

[0058] B. Citric acid and potassium ferrocyanide (K 4 [Fe(CN) 6 ]) Preparation of mixed solution

[0059] A certain amount of citric acid and K 4 [Fe(CN) 6 ] aqueous solution to make the final concentration of citric acid 0.25M, and make K 4 [Fe(CN) 6 ] at a concentration of 0.05M.

[0060] C. Synthesis of Prussian Blue Nanoparticles

[0061] Heat the mixed solution prepared in steps A and B to 60°C respectively, then add the mixed solution prepared in step B dropwise to the mixed solution prepared in step A at 60°C with stirring, the stirring speed is 500rpm / min, the dropping speed It is 0.8mL / min. After the dropwise addition was completed, the reaction was stirred at 60° C. for 30 min, and then cooled to r...

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Abstract

The invention relates to a near infrared photo-thermal conversion agent based on prussian blue and application of the agent in tumor photo-thermal excision treatment. The prussian blue is an ancient dye, and is also a clinical medicine for treating thallium radiation poisoning; the prussian blue has the high absorption capability in a near-infrared area, the absorbed near-infrared light can be converted into heat to excise tumor cells through the converted high heat in a targeted manner, so that the prussian blue can be applied to photo-thermal treatment on tumor. Compared with the conventional photo-thermal treatment agent, the prussian blue has the advantages of high photo-thermal conversion rate, low cost and simple preparation, and most importantly, as the prussian blue has clinical medication experience for years, the biosecurity of the prussian blue in human bodies can be ensured.

Description

Technical field: [0001] The invention belongs to the technical field of biomaterials, and specifically relates to the development of Prussian blue, a drug with many years of clinical experience, into a biomaterial that can perform photothermal conversion in the near-infrared light region, and focuses on using it as a near-infrared photothermal Conversion agents are used in photothermal ablation therapy of tumors. technical background: [0002] Photothermal therapy is a tumor treatment method that utilizes hyperthermia. This method mainly uses photothermal conversion agents to convert light into heat, thereby killing targeted tumor cells through locally increased heat. Different from conventional treatment methods, photothermal therapy can target and kill tumor cells through photothermal conversion agents and lasers, so as not to damage the normal tissues around the tumor and cause little side damage to the human body. At the same time, this method can efficiently kill tumor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61P35/00
Inventor 戴志飞付光磊梁晓龙
Owner PEKING UNIV
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