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Composite lysozyme oral spray and preparation method thereof

An oral spray, lysozyme technology, applied in aerosol delivery, topical antibacterial agents, drug combinations, etc., can solve the problem of unusable prevention of oral diseases or daily cleaning of the mouth, fresh breath, inconvenience for patients with oral diseases, and bacterial resistance. Drug-induced gastrointestinal problems, to achieve the effect of not being resistant to drug resistance, beneficial to wound healing, and inhibiting oral Streptococcus mutans

Inactive Publication Date: 2014-04-23
童渝
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Traditionally, antibiotics and antibacterial agents are used to kill oral pathogenic bacteria. For the convenience of use and quick effect, sprays are usually used for drug administration of oral diseases, but most of the sprays contain alcohol, which brings harm to patients with oral diseases such as driving. inconvenient
At the same time, antibiotics and bacteriostatic agents are likely to cause bacteria to develop drug resistance or side effects such as gastrointestinal discomfort, especially when oral diseases recur, the bactericidal effect of antibiotics and bacteriostatic agents will gradually decrease, affecting the therapeutic effect
Similarly, sprays containing antibiotics and antibacterial agents should not be used for a long time, and should not be used for daily health care to prevent oral diseases or for daily cleaning of the mouth and fresh breath

Method used

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  • Composite lysozyme oral spray and preparation method thereof
  • Composite lysozyme oral spray and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Take the preparation of 100 grams of compound lysozyme oral spray as an example:

[0026] 1. Weigh 3 grams of lysostaphin and 20 grams of lysozyme and dissolve in 30 grams of distilled water;

[0027] 2. Weigh 1 gram of sorbitol and 0.01 gram of xanthan gum and dissolve in 30 grams of distilled water;

[0028] 3. Mix and stir the solutions obtained in steps 1 and 2 to obtain Liquid A;

[0029] 4. Weigh 1 gram of vitamin C and 0.02 gram of tea polyphenols and dissolve in 12.47 grams of distilled water;

[0030] 5. Weigh 1 gram of lecithin and add it to 1.5 grams of olive oil, stir in a constant temperature water bath to dissolve;

[0031] 6. Mix and stir the solutions obtained in steps 4 and 5 to obtain liquid B;

[0032] 7. Mix liquids A and B, and use a high-pressure homogenizer with a high pressure of 25MP to homogenize 3 times, and the product is the product;

[0033] 8. Filling at a temperature higher than 80 degrees Celsius.

Embodiment 2

[0035] Take the preparation of 200 grams of compound lysozyme oral spray as an example:

[0036] 1. Weigh 7 grams of lysostaphin and 45 grams of lysozyme and dissolve in 50 grams of distilled water;

[0037] 2. Weigh 6 grams of sorbitol and 0.1 grams of xanthan gum and dissolve them in 50 grams of distilled water;

[0038] 3. Mix and stir the solutions obtained in steps 1 and 2 to obtain Liquid A;

[0039] 4. Weigh 3 grams of vitamin C and 0.5 grams of tea polyphenols and dissolve them in 38.4 grams of distilled water;

[0040] 5. Weigh 3 grams of lecithin and add it to 5 grams of olive oil, stir in a constant temperature water bath to dissolve;

[0041] 6. Mix and stir the solutions obtained in steps 4 and 5 to obtain liquid B;

[0042] 7. Mix liquids A and B, and use a high-pressure homogenizer with a high pressure of 25MP to homogenize 3 times, and the product is the product;

[0043] 8. Filling at a temperature higher than 80 degrees Celsius.

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Abstract

The invention relates to a composite lysozyme oral spray and a preparation method thereof. The composite lysozyme oral spray is remarkable in effect and convenient to use, and does not contain alcohol; all components are extracted from natural products, enable fresh breath after used and do not have toxic or side effect under combined action of lysozyme, tea polyphenol and vitamin C; the oral spray has good prevention and treatment effects to dental ulcer, decsyed teeth, aphtha, ozostomia, glossitis, sphagitis and other dental diseases; the preparation method is concise and effect, and low in cost; the prepared composite lysozyme oral spray is good in stability.

Description

technical field [0001] The invention relates to an oral spray biological preparation for killing oral pathogenic bacteria, in particular to a compound lysozyme oral spray and a preparation method thereof. Background technique [0002] The oral cavity is an important part of the digestive and respiratory systems of the human body. With the aggravation of air pollution and environmental deterioration, oral diseases are on the rise. [0003] Oral diseases are mostly caused by oral bacteria, such as oral ulcers, periodontal disease, tongue disease, dental caries, bad breath, pharyngitis, etc. Modern medicine believes that oral diseases can cause sepsis, diabetes, heart disease, etc. Therefore, killing oral pathogenic bacteria is the key to treating and preventing oral diseases. [0004] Traditionally, antibiotics and antibacterial agents are used to kill oral pathogenic bacteria. For the convenience of use and quick effect, sprays are usually used for drug administration of ora...

Claims

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Application Information

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IPC IPC(8): A61K38/47A61K9/12A61P1/02A61P31/02A61P11/04A61K36/82A61K31/375
Inventor 陈新宇童渝顾晓华
Owner 童渝
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