Composite lysozyme oral spray and preparation method thereof
An oral spray, lysozyme technology, applied in aerosol delivery, topical antibacterial agents, drug combinations, etc., can solve the problem of unusable prevention of oral diseases or daily cleaning of the mouth, fresh breath, inconvenience for patients with oral diseases, and bacterial resistance. Drug-induced gastrointestinal problems, to achieve the effect of not being resistant to drug resistance, beneficial to wound healing, and inhibiting oral Streptococcus mutans
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[0024] Example 1
[0025] Take the preparation of 100 grams of compound lysozyme oral spray as an example:
[0026] 1. Weigh 3 grams of lysostaphin and 20 grams of lysozyme and dissolve in 30 grams of distilled water;
[0027] 2. Weigh 1 gram of sorbitol and 0.01 gram of xanthan gum and dissolve in 30 grams of distilled water;
[0028] 3. Mix and stir the solutions obtained in steps 1 and 2 to obtain Liquid A;
[0029] 4. Weigh 1 gram of vitamin C and 0.02 grams of tea polyphenols and dissolve them in 12.47 grams of distilled water;
[0030] 5. Weigh 1 gram of lecithin, add 1.5 grams of olive oil, stir and dissolve in a constant temperature water bath;
[0031] 6. Mix and stir the solutions obtained in steps 4 and 5 to obtain liquid B;
[0032] 7. Mix liquid A and B, use a high-pressure homogenizer for high-pressure 25MP homogenization 3 times, the result is the product;
[0033] 8. The temperature is higher than 80 degrees Celsius for high temperature filling.
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[0034] Example 2
[0035] Take the preparation of 200 grams of compound lysozyme oral spray as an example:
[0036] 1. Weigh 7 grams of Lysostaphin and 45 grams of Lysozyme and dissolve them in 50 grams of distilled water;
[0037] 2. Weigh 6 grams of sorbitol and 0.1 grams of xanthan gum and dissolve them in 50 grams of distilled water;
[0038] 3. Mix and stir the solutions obtained in steps 1 and 2 to obtain Liquid A;
[0039] 4. Weigh 3 grams of vitamin C and 0.5 grams of tea polyphenols and dissolve them in 38.4 grams of distilled water;
[0040] 5. Weigh 3 grams of lecithin, add 5 grams of olive oil, stir to dissolve in a constant temperature water bath;
[0041] 6. Mix and stir the solutions obtained in steps 4 and 5 to obtain liquid B;
[0042] 7. Mix liquid A and B, use a high-pressure homogenizer for high-pressure 25MP homogenization 3 times, the result is the product;
[0043] 8. The temperature is higher than 80 degrees Celsius for high temperature filling.
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