Green synthetic method of fluorescence copper nano-cluster, and application of fluorescence copper nano-cluster

A fluorescent copper nanocluster and green synthesis technology, applied in nanotechnology, nanotechnology, fluorescence/phosphorescence, etc., can solve the problems of low signal enhancement in vivo, poor probe stability, poor probe transportation, etc., to achieve Rapid and precise positioning and tumor-targeted imaging analysis, realization of positioning and tumor-targeted imaging analysis, and the effect of real-time in situ tumor-targeted fluorescence imaging
CN103820106AInactive Publication Date: 2014-05-28SOUTHEAST UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
SOUTHEAST UNIV
Publication Date
2014-05-28
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention discloses a green synthetic method of a fluorescence copper nano-cluster, and an application of the fluorescence copper nano-cluster. The synthetic method concretely comprises the following steps: incubating a certain concentration of a copper salt solution and different kinds of tumor cells, and carrying out in-situ synthesis to obtain a copper nano-cluster having an excellent fluorescence performance in order to realize the real time and high resolution fluorescence imaging of the tumor cells. The copper nano-cluster can realize the rapid real-time in-situ in-vivo tumor targeting fluorescence imaging on a tumor-hearing nude mouse model. The copper nano-cluster is prepared through direct biosynthesis of tumor cells and has a very good biocompatibility; and the method has the characteristics of environmental protection, no pollution to the environment, realization of rapid and accurate positioning and tumor targeting imaging analysis by the in-situ synthesis reaction, simplicity, easy implementation, accuracy and high efficiency.
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Description

technical field

[0001] The invention relates to a green synthesis method of fluorescent copper nanoclusters and its application. Specifically, a copper salt solution of a certain concentration is incubated with different types of tumor cells to synthesize copper nanoclusters with excellent fluorescent properties in situ, thereby achieving the realization of Real-time, high-resolution fluorescence imaging of tumor cells. At the same time, the copper nanocluster of the present invention can realize rapid and real-time in situ tumor-targeted fluorescent imaging in a tumor-bearing nude mouse model. The copper nanocluster of the present invention is directly biosynthesized by tumor cells, and has good biocompatibility; the method is green and environmentally friendly, has no pollution to the environment, and its in-situ synthesis reaction can realize rapid and precise positioning and tumor-targeted imaging Analysis has the characteristics of simplicity, precision and efficiency. ...

Claims

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