Preparation method of hypertonic resuscitation fluid and application thereof

Abstract

The invention relates to a preparation method of a hypertonic sodium chloride dextran 70 resuscitation fluid and application of the hypertonic resuscitation fluid. Specifically, further improvement is made to the existing preparation technology of hypertonic resuscitation fluids by the invention, the technological steps are simplified, and the technical parameters are optimized, so that the hypertonic sodium chloride dextran 70 resuscitation fluid product with more stable quality and lower cost can be prepared.

Description

technical field [0001] The present invention relates to a preparation method of hypertonic resuscitation fluid and the application of the hypertonic resuscitation fluid. Specifically, the present invention provides a preparation method of hypertonic sodium chloride dextran 70 resuscitation fluid and the application of the hypertonic resuscitation fluid . Background technique [0002] Hemorrhagic shock (HS for short) is a common type of shock in which the circulating blood volume is suddenly reduced due to blood loss, often secondary to trauma or other diseases, and is a type of hypovolemic shock. Hemorrhagic shock often occurs after traumatic hemorrhage, gastrointestinal bleeding, postoperative hemorrhage or coagulation abnormalities. In the treatment of hemorrhagic shock, resuscitation fluid or plasma substitutes are used. The hypertonic resuscitation solution referred to in the present invention is hypertonic sodium chloride dextran 70 (aqueous solution of 7.5% NaCl and ...

AI Technical Summary

Problems solved by technology

Low- and small-molecule dextran also has the effect of expanding blood volume, but the effect is shorter than that of medium-molecule dextran, and when used as a resuscitation fluid, it is more likely to cause side effects such as allergic reactions than dextran 70

[0004] Though the preparation method of hypertonic sodium chloride dextran 70 resuscitation liquid has many document reports at present, wherein, the applicant of the present invention just once disclosed a kind of preparation method in the patent application 200410091454.0, but, in this production process, some The problem is still not solved, and there are still many places that can be optimized in the production process. For example, a large amount of activated carbon needs to be used in the production process to remove pyrogens such as bacterial protein and metabolic residues contained in the dextran raw material, thereby increasing the original viscosity. The difficulty of filtering the larger dextran 70 solution makes the process cumbersome and increases the cost accordingly. At the same time, a large amount of activated carbon and multiple filtration processes will greatly reduce the content of dextran 70 and reduce the quality of the produced product. quality; in addition, dextran 70 is easy to degrade at high temperature, and the stability of dextran 70 is just the key factor affecting the quality of hypertonic resuscitation fluid drugs, that is, in the process of production, transportation, storage and use, it is necessary to ensure that hypertonic resuscitation The degradation of dextran 70 in the solution is as little as possible, and the average molecular weight changes as little as possible, but the solubility of dextran 70 is better at high temperature, so in the whole project of preparing hypertonic resuscitation fluid, it is always necessary to use it in a high temperature solution environment to operate

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