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Resting-state brain default mode network imaging method and application thereof

A resting state, imaging technology used in the field of biomedicine

Inactive Publication Date: 2014-06-11
AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there have been no reports on the use of DMN to evaluate the effect (therapeutic effect) of acupuncture on chronic pain at home and abroad.

Method used

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  • Resting-state brain default mode network imaging method and application thereof
  • Resting-state brain default mode network imaging method and application thereof
  • Resting-state brain default mode network imaging method and application thereof

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Experimental program
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Embodiment 1

[0022] Research object:

[0023] 20 patients with chronic low back pain (including chronic sciatica) (from the Department of Rehabilitation and Acupuncture and Moxibustion, Huashan Hospital Affiliated to Fudan University) were the treatment group, with 10 males and 10 males each, aged 32-45 years, with an average (39.5±5.9), and selected 10 healthy people were the healthy control group, 5 males and 5 males, aged 33-44 years old, with an average age of (37.7±5.1) years old (from the staff volunteers of Huashan Hospital Affiliated to Fudan University), and there was no difference in age and sex data between the two groups. Statistically significant (p>0.05);

[0024] Inclusion criteria:

[0025] (1) Patients with chronic low back pain and / or chronic sciatica (dry type) all have pain lasting for more than 6 months; visual analogue scale (VAS) measures pain intensity ≥ 5 points; no sedation is taken for 24 hours during acupuncture Or painkillers, no acupuncture treatment within ...

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Abstract

The invention belongs to the field of biomedicine, relates to a brain default mode network imaging method, in particular to a resting-state brain default mode network imaging method and application of the method to evaluation of curative effect on chronic low back pain and / or chronic sciatica by acupuncture treatment. Research proves that brain DMN (default mode network) activities can reflect chronic pain; if patients with chronic low back pain have abnormal DMN activities, when acupuncture is performed on the patients with chronic low back pain, the abnormal DMN activities of the patients can be corrected, and DMN recovers to the state of a normal person along with reduction or disappearance of symptoms. An independent component analysis data processing method is adopted, resting-state brain DMN activity fMRI (functional magnetic resonance imaging) data are extracted, and objective imageology bases after acupuncture analgesia treatment are obtained. The obtained objective imageology bases are conducive to understanding of reasons for chronic pain continuing of the patients with the chronic low back pain by acupuncture intervention.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to a brain default network imaging method, in particular to the application of a resting state brain default network imaging method in evaluating the curative effect of acupuncture in treating chronic pain, and the chronic pain includes chronic low back pain and / or Chronic sciatica disease. Background technique [0002] The prior art discloses that chronic pain refers to that the pain is still recurrent and spontaneous for more than 6 months after the removal of the primary injury. It has been found in clinical practice that specific treatment can improve the pain symptoms of certain patients after an acute attack, but it is rarely clear that after the primary lesion is cured in some patients, the pain still recurs and lasts for a long time, leading to chronic pain. Clinical treatment practice shows that this chronic pain is difficult to cure, which is the difficulty of current treatment. ...

Claims

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Application Information

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IPC IPC(8): A61B5/00
Inventor 李霁汤伟军董竞成吴金峰乐晶晶
Owner AFFILIATED HUSN HOSPITAL OF FUDAN UNIV