Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Ciprofloxacin and metronidazole-containing liquid preparation

A liquid preparation, the technology of ciprofloxacin, which is applied in anti-inflammatory agents, non-central analgesics, respiratory diseases, etc., can solve the problem of no effect

Inactive Publication Date: 2014-06-18
TIANJIN HANKANG PHARMA BIOTECH
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Metronidazole is potent against most anaerobic bacteria but has no effect on aerobes and facultative anaerobes

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] ① Dissolve 2g of sodium carboxymethylcellulose in a beaker with 200ml of distilled water, heat to 40°C, filter while hot, and let cool to form a glue for later use;

[0045] ②Put 50g of glycerin in a mortar. After 5g of ciprofloxacin passed through a 100-mesh sieve is treated with microcrystals, it is added to the glycerin for grinding and dispersion, and then the mortar prepared in step ① is added in three times. Gradually add 300ml distilled water and grind to make a suspension;

[0046] ③Put 3g of metronidazole in a beaker, add 100ml of distilled water, heat to dissolve the filtered filtrate and combine with the suspension prepared in step ②, grind, and finally add distilled water to 1000ml and stir to form a milky white suspension.

Embodiment 2

[0048] ① Dissolve 3g of sodium carboxymethylcellulose in a beaker with 200ml of distilled water, heat to 40°C, filter while it is hot, and let it cool to form a glue for later use;

[0049] ②Take 100g of glycerin and place it in a mortar. After 15g of ciprofloxacin passed through a 100-mesh sieve is treated with microcrystals, it is added to the glycerin for grinding and dispersion, and then the mortar prepared in step ① is added in three times. Gradually add 300ml distilled water and grind to make a suspension;

[0050] ③Put 10g of metronidazole in a beaker, add 100ml of distilled water, heat to dissolve the filtered filtrate and combine with the suspension prepared in step ②, grind, and finally add distilled water to 1000ml and stir to form a milky white suspension.

Embodiment 3

[0052] ① Dissolve 2.5g of sodium carboxymethylcellulose in a beaker with 200ml of distilled water, heat to 40°C, filter while hot, and let cool to form a glue for later use;

[0053] ②Put 80g of glycerin in a mortar, 10g of ciprofloxacin passed through a 100-mesh sieve is treated with microcrystals, then added to glycerin for grinding and dispersion, and then add the mortar prepared in step ① three times, and then Gradually add 300ml distilled water and grind to make a suspension;

[0054] ③Put 5g of metronidazole in a beaker, add 100ml of distilled water, heat to dissolve the filtered filtrate and combine with the suspension prepared in step ②, grind, and finally add distilled water to 1000ml and stir to form a milky white suspension.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a medicinal preparation used for ear, which is used for treating acute tympanitis, chronic tympanitis, otitis externa and myringitis. The preparation is mainly composed of ciprofloxacin and metronidazole. The ciprofloxacin and metronidazole-containing liquid preparation can be respectively prepared to ear liquid, collunarium liquid, a solution for surgery and a solution for gynaecology according to clinical requirement. The ciprofloxacin and metronidazole-containing liquid preparation has the characteristics of wide antimicrobial spectrum, high curative effect, less side-effect and low price.

Description

technical field [0001] The invention relates to an auris pharmaceutical preparation suitable for treating acute and chronic otitis media, otitis externa, and tympanic myringitis, which is characterized in that ciprofloxacin and metronidazole are the main components and can be mixed with a liquid pharmaceutical preparation of auxiliary drugs. The weight percentage of ciprofloxacin is 1.0-2.0%, and the weight percentage of metronidazole is 0.3-0.5%. Background technique [0002] Acute and chronic otitis media, otitis externa, and tympanitis are common diseases in clinical otology, especially chronic otitis media is one of the stubborn diseases of otology. Escherichia coli, some chronic otitis media may be accompanied by mixed infections such as anaerobic bacteria. Chloramphenicol ear drops, compound neomycin nasal drops, nitrofurazone solution, metronidazole solution, etc. currently used in the treatment of suppurative otitis media, sinusitis, and various suppurative infectio...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/496A61K31/4164A61K47/38A61K47/10A61P27/16A61P29/00A61P11/02
Inventor 严洁李轩
Owner TIANJIN HANKANG PHARMA BIOTECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com