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A kind of embedded particle and its preparation method and application

A technology of granule and embedding agent, which is applied in pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., can solve the problems of difficulty in increasing bone density, poor taste of health care products, and low stability. , to achieve the effect of long shelf life, good stability and high stability

Active Publication Date: 2022-08-02
北京斯利安药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the problems of poor taste, low stability, short shelf life and difficulty in increasing bone density in various health care products for the treatment of osteoporosis, it is necessary to find a way to make such calcium tablets contain vitamin K, the active ingredient, during storage. 2 Composition with more stable content and longer shelf life and preparation method

Method used

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  • A kind of embedded particle and its preparation method and application
  • A kind of embedded particle and its preparation method and application
  • A kind of embedded particle and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0100] Embodiment 1 Calcium tablet suitable for women during pregnancy and lactation and preparation method thereof

[0101] Raw materials, in parts by weight, include the following components:

[0102]

[0103] The preparation method includes the following steps:

[0104] (1), ingredients: the sodium carboxymethyl cellulose of the formula consumption is sieved for subsequent use;

[0105] (2), the preparation of embedded particles: 1 / 5 of the formula dosage of sodium carboxymethyl cellulose is dispersed in 95% ethanol of 2.5 times the mass of sodium carboxymethyl cellulose of the formula dosage, and 2 times the amount of 95% ethanol is added. water to form a transparent colloidal solution, use this solution to granulate vitamin K2 in a fluidized bed, and dry to obtain embedded particles 1,

[0106] The granulation conditions are: the temperature is 55℃; the atomization pressure is 0.2Mpa, and the air volume is 60m 3 / h;

[0107] Disperse 1 / 5 of the formula dosage of s...

Embodiment 2

[0117] Embodiment 2 Calcium tablets suitable for women during pregnancy and lactation and preparation method thereof

[0118] The only difference from Example 1 is that the vitamin K in the raw material 2 : Sodium carboxymethyl cellulose=1:1.5; the raw materials include the following components in parts by weight:

[0119]

[0120]

[0121] The preparation method will include the following steps:

[0122] (1), ingredients: the sodium carboxymethyl cellulose of the formula consumption is sieved for subsequent use;

[0123] (2), granulation, drying and granulation: 1 / 5 of the sodium carboxymethyl cellulose of the formula dosage is dispersed in 95% ethanol of 3 times the quality of the sodium carboxymethyl cellulose of the formula dosage, and 2 times the amount of 95% is added. Ethanol water to form a transparent colloidal solution, use this solution to granulate vitamin K2 in a fluidized bed, and dry to obtain embedded particles 1,

[0124] The granulation conditions ...

Embodiment 3

[0137] Embodiment 3 Calcium tablets suitable for women during pregnancy and lactation and preparation method thereof

[0138] The only difference from Example 2 is that the vitamin K in the raw material 2 : Sodium carboxymethyl cellulose=1:2; the raw materials include the following components by weight:

[0139]

[0140] The preparation method will include the following steps:

[0141] (1), ingredients: the sodium carboxymethyl cellulose of the formula consumption is sieved for subsequent use;

[0142] (2), granulation, drying and granulation: 1 / 5 of the formula dosage of sodium carboxymethyl cellulose is dispersed in 95% ethanol of 3.5 times the mass of sodium carboxymethyl cellulose of the formula dosage, and 2 times the amount of 95% is added. Ethanol water to form a transparent colloidal solution, use this solution to granulate vitamin K2 in a fluidized bed, and dry to obtain embedded particles 1,

[0143] The granulation conditions are: the temperature is 55℃; the...

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Abstract

The present application discloses an embedded particle and a preparation method and application thereof. The embedded particles include a vitamin K2 inner core, an embedding agent layer I, a vitamin D3 layer, an embedding agent layer II, a calcium source layer, and an embedding agent layer III from the inside to the outside; wherein, the calcium source layer, the vitamin D3 layer, The mass ratio of the vitamin K2 inner core and the embedding agent is 50.5-75: 0.13-0.19: 1.0-1.4: 0.1-5; the quality of the embedding agent is the embedding agent layer I, the embedding agent layer II, the embedding agent The sum of the masses of layer III. The embedded particles have a layer-by-layer embedded structure, with higher stability and longer shelf life.

Description

technical field [0001] The application relates to an embedded particle, a preparation method and application thereof, and belongs to the technical field of calcium supplementation products. Background technique [0002] Osteoporosis is a group of bone diseases caused by a variety of reasons, which can occur in different genders and different ages. It usually manifests as increased bone fragility and susceptibility to fractures due to decreased bone content per unit volume and abnormal bone structure. Pregnant and lactating women are one of the most prone groups to suffer from osteoporosis. The main reasons are: (1) local trauma caused during childbirth, resulting in insufficient bone formation due to vascular and neurotrophic disorders; (2) pregnancy During this period, the fetus ingests maternal calcium to complete bone metabolism, thereby reducing the calcium in the mother; (3) In addition to supplementing their own nutritional needs during pregnancy and lactation, women a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/593A61K33/10A61K33/42A61K47/38A61K47/36A61K47/32A61P3/02A61K31/122A61K31/194
CPCA61K9/2081A61K9/2059A61K9/2027A61K9/2095A61K31/194A61K33/42A61K33/10A61K31/593A61K31/122A61P3/02A61K2300/00
Inventor 雷本龙闫东海谭玉霞
Owner 北京斯利安药业有限公司
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