Embedded particle as well as preparation method and application thereof

A technology of granules and embedding agents, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., and can solve the problems of poor taste, short shelf life, and low stability of health care products

Active Publication Date: 2021-09-10
北京斯利安药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the problems of poor taste, low stability, short shelf life and difficulty in increasing bone density in various health care products for the treatment of osteoporosis, it is n

Method used

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  • Embedded particle as well as preparation method and application thereof
  • Embedded particle as well as preparation method and application thereof
  • Embedded particle as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0100] Example 1 Pregnancy, breast-feeding women suitable calcium tablet and preparation method thereof

[0101] The raw materials include the following components in parts by weight:

[0102]

[0103] The preparation method comprises the following steps:

[0104] (1), batching: the sodium carboxymethyl cellulose of formula consumption is sieved for subsequent use;

[0105] (2), preparation of embedding particles: disperse 1 / 5 of the formula dosage sodium carboxymethyl cellulose in 95% ethanol of 2.5 times the formula dosage sodium carboxymethyl cellulose quality, add 2 times the amount of 95% ethanol water to form a transparent colloidal solution, use this solution to granulate vitamin K2 in a fluidized bed, and dry to obtain embedding granules 1,

[0106] The granulation conditions are: the temperature is 55°C; the atomization pressure is 0.2Mpa, and the air volume is 60m 3 / h;

[0107] Disperse 1 / 5 of the formula dosage sodium carboxymethyl cellulose in 95% ethanol ...

Embodiment 2

[0117] Example 2 Pregnancy, breast-feeding women suitable calcium tablet and preparation method thereof

[0118] The only difference from Example 1 is that the vitamin K in the raw material 2 : Sodium carboxymethyl cellulose=1:1.5; Raw material comprises the following components by weight:

[0119]

[0120]

[0121] The preparation method will include the following steps:

[0122] (1), batching: the sodium carboxymethyl cellulose of formula consumption is sieved for subsequent use;

[0123] (2), granulation, drying and sizing: disperse 1 / 5 of the formula dosage of sodium carboxymethyl cellulose in 95% ethanol of 3 times the formula dosage of sodium carboxymethyl cellulose quality, add 2 times the amount of 95% Ethanol water forms a transparent colloidal solution, which is used to granulate vitamin K2 in a fluidized bed, and dried to obtain embedded granules 1,

[0124] The granulation conditions are: the temperature is 55°C; the atomization pressure is 0.2MpaMpa, an...

Embodiment 3

[0137] Example 3 Pregnancy, breast-feeding women suitable calcium tablet and preparation method thereof

[0138] The only difference with Example 2 is that the vitamin K in the raw material 2 : Sodium Carboxymethyl Cellulose=1:2; The raw material comprises the following components in parts by weight:

[0139]

[0140] The preparation method will include the following steps:

[0141] (1), batching: the sodium carboxymethyl cellulose of formula consumption is sieved for subsequent use;

[0142] (2), granulation, drying and sizing: disperse 1 / 5 of the formula dosage of sodium carboxymethyl cellulose in 95% ethanol of 3.5 times the formula dosage of sodium carboxymethyl cellulose quality, add 2 times the amount of 95% Ethanol water forms a transparent colloidal solution, which is used to granulate vitamin K2 in a fluidized bed, and dried to obtain embedded granules 1,

[0143] The granulation conditions are: the temperature is 55°C; the atomization pressure is 0.2MpaMpa, a...

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Abstract

The invention discloses an embedded particle as well as a preparation method and application thereof. The embedded particles comprises a vitamin K2 inner core, an embedding medium layer I, a vitamin D3 layer, an embedding medium layer II, a calcium source layer and an embedding medium layer III from inside to outside, wherein the mass ratio of the calcium source layer to the vitamin D3 layer to the vitamin K2 inner core to the embedding medium is (50.5-75): (0.13-0.19): (1.0-1.4): (0.1-5), and the mass of the embedding medium is the sum of the mass of the embedding medium layer I, the embedding medium layer II and the embedding medium layer III. The embedded particle has a layer-by-layer embedded structure, and is higher in stability and longer in shelf life.

Description

technical field [0001] The application relates to an embedding granule and its preparation method and application, belonging to the technical field of calcium supplement products. Background technique [0002] Osteoporosis is a group of bone diseases caused by a variety of reasons, which can occur in different genders and ages. It usually manifests as increased bone fragility and susceptibility to fracture due to decreased bone content per unit volume and abnormal bone tissue structure. Pregnant and breastfeeding women are one of the groups prone to osteoporosis. The main reasons are: (1) Local trauma caused during childbirth, which leads to bone blood and neurotrophic disorders, resulting in insufficient bone formation; (2) Pregnancy During this period, the fetus takes in the mother’s calcium to complete bone metabolism, thereby reducing the calcium in the mother’s body; (3) In addition to supplementing their own nutritional needs, pregnant and lactating women also need to ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/593A61K33/10A61K33/42A61K47/38A61K47/36A61K47/32A61P3/02A61K31/122A61K31/194
CPCA61K9/2081A61K9/2059A61K9/2027A61K9/2095A61K31/194A61K33/42A61K33/10A61K31/593A61K31/122A61P3/02A61K2300/00
Inventor 雷本龙闫东海谭玉霞
Owner 北京斯利安药业有限公司
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