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A kind of brush type copolymer with sugar, temperature and pH triple sensitivity and preparation method thereof
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A technology of copolymer and sensitivity, applied in the field of brush-type copolymer and its preparation, can solve the problems of drug resistance, liver and kidney damage, chronic damage of patients, etc., and achieve the effect of good biocompatibility
Inactive Publication Date: 2016-08-17
TONGJI UNIV
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Hyperglycemia is caused by defects in insulin secretion and its biological effects, which can lead to chronic damage and dysfunction of various tissues, especially the eyes, kidneys, heart, blood vessels, and nerves. Lowering blood sugar is currently the main method for treating diabetes , the traditional injection and taking of medicines requires doctors and patients to strictly control the dosage of medicines. Prolonged use will also make patients develop drug resistance and cause diabetic liver and kidney damage
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Embodiment 1
[0023] 1) 0.189g (0.1mmol) poly(p-azidomethylstyrene), 0.9913 (10mmol) DMA (N,N-dimethylacrylamide), 3mg (0.02mol) AIBN (azobisisobutyl Cyanide) was dissolved in 4ml of DMF, degassed by freezing and vacuuming three times, and reacted at 70°C for 24 hours under the protection of nitrogen atmosphere. After the reaction was finished, it was diluted with tetrahydrofuran, and the diluted solution was precipitated in frozen n-hexane, and the dissolution-precipitation was repeated three times, then filtered, and then dried in a vacuum oven for 48 hours to obtain polymer I;
[0024] 2) Under nitrogen protection, 0.0193g (0.1mmol) propargyl α-2 bromoisobutyrate, 0.0173g 0.0208g (0.12mmol) cuprous bromide, (0.12mmol) PMDETA and 2.738 (10mmol) PpBDEMA The monomer was dissolved in dry anisole and refrigerated and pumped three times, stirred at 90°C for 18-60 hours, concentrated to remove copper salt, and then precipitated in a mixture of n-hexane and ether to obtain Polymer II:
[0025] ...
Embodiment 2
[0027] 1) with embodiment 1 step 1);
[0028] 2) Under the protection of nitrogen, 0.0193g (0.1mmol) propargyl α-2 bromoisobutyrate, 0.0173g 0.0208g (0.12mmol) cuprous bromide, (0.12mmol) PMDETA and 2.1904g (8mmol) PpBDEMA monomer was dissolved in dry anisole and refrigerated and pumped three times, stirred at 90°C for 18-60 hours, concentrated to remove copper salt, and then precipitated in a mixture of n-hexane and ether to obtain Polymer II:
[0029] 3) Same as Step 3 of Example 1).
Embodiment 3
[0031] 1) with embodiment 1 step 1);
[0032] 2) Under the protection of nitrogen, 0.0193g (0.1mmol) propargyl α-2 bromoisobutyrate, 0.0173g0.0208g (0.12mmol) cuprous bromide, (0.12mmol) PMDETA and 1.6428g (6mmol) PpBDEMA monomer was dissolved in dry anisole and refrigerated and pumped three times, stirred at 90°C for 18-60 hours, concentrated to remove copper salt, and then precipitated in a mixture of n-hexane and ether to obtain Polymer II:
[0033] 3) Same as Step 3 of Example 1).
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Abstract
The invention belongs to the fields of polymer materials and biomedical engineering, and particularly relates to a brush copolymer with sugar, temperature and pH triple sensitivities, and a preparing method thereof. The preparing method mainly includes a first step of initiating polymerization of 4-vinylbenzyl chloride by an RAFT chain transfer agent, performing azidation, and initiating polymerization of DMA by adopting the product as a macromolecule RAFT chain transfer agent; a second step of initiating polymerization of a monomer (2-phenylborate-5-ethyl-1,3-dioxane) methacrylate (PpBDEMA) by adopting isopropyl 2-bromo-2-methylpropionate as an ATRP initiator; and a third step of subjecting the first polymer and the second polymer to azidation to obtain a third polymer. Phenylboronic acid falls off from the polymer after the polymer provided by the invention responds to sugar and the phenylboronic acid and the sugar form a micromolecule complex, and therefore the phenylboronic acid can be excreted from the body together with metabolism in the body. The polymer provided by the invention has good biocompatibility. The copolymer has sugar, temperature and pH triple responsive properties, and can be used in the fields of drug release, chemical sensors, polymer separation, and the like.
Description
technical field [0001] The invention relates to a brush-type copolymer with triple sensitivity of sugar, temperature and pH and a preparation method thereof. Background technique [0002] Compared with single-stimuli-responsive systems that have been studied more, the development of dual- and multiple-stimuli-responsive systems has more important significance for scientific research and practical applications. First, polymer systems with multiple responsiveness can be used to study the release kinetics of the system. These systems can independently adjust each response behavior for different stimuli, such as enhancing or weakening drug release at the same time. Second, organisms have complex stimulus-response behaviors, and this type of research is of great benefit to the research of diseases such as diabetes and cancer. The multi-responsive polymer drug delivery materials can form micelles of different shapes or lead to the disintegration of micelles under different stimul...
Claims
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Application Information
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