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Sun screening agent-coated solid lipid sunscreen particle and preparation method thereof

A technology for solid lipids and sunscreen agents, which is used in pharmaceutical formulations, cosmetic formulations, cosmetic formulations, etc., can solve the problems of uneven sample dispersion and large dispersion coefficient, and achieves easy precipitation, uniform dispersion, and particle size. small effect

Inactive Publication Date: 2014-08-27
SHANGHAI INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The purpose of the present invention is to solve the problem that the high-pressure homogenization may cause the final nano-particle size to be too small, so that the sunscreen agent penetrates into the skin, and the sample obtained by the ordinary emulsification method will be unevenly dispersed and have a large dispersion coefficient. A preparation method for synergistically preparing solid lipid sunscreen particles coated with sunscreen, the preparation method has the advantages of simple operation, uniform dispersion of nanoparticles, and a particle size of 290-400nm

Method used

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  • Sun screening agent-coated solid lipid sunscreen particle and preparation method thereof
  • Sun screening agent-coated solid lipid sunscreen particle and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] A solid lipid sunscreen granule coated with a sunscreen, calculated according to the total amount of 100g, its composition and content are as follows:

[0047] Solid sunscreen 1g (1%)

[0048] Liquid sunscreen 3g (3%)

[0049] Solid Lipid 2g (2%)

[0050] Liquid Lipid 3g (3%)

[0051] Solid emulsifier 3g (3%)

[0052] Additive 0.5g (0.5%)

[0053] Preservatives 0.01g (0.01%)

[0054] The balance is deionized water;

[0055] Described solid sunscreen is butylmethoxydibenzoylmethane;

[0056] The liquid sunscreen is octyl methyl cinnamate;

[0057] Described solid lipid is glyceryl monostearate;

[0058] The liquid lipid is caprylic acid / capric triglyceride;

[0059] Described solid emulsifier is isomeric cetyl ether;

[0060] Described additive is sodium chloride;

[0061] The preservative is diazolidinyl urea.

[0062] The preparation method of the above-mentioned solid lipid sunscreen particles coated with sunscreen is characterized in that it specifically co...

Embodiment 2

[0074] A solid lipid sunscreen granule coated with a sunscreen, calculated according to the total amount of 100g, its composition and content are as follows:

[0075] Solid Sunscreen 5g(5%)

[0076] Liquid sunscreen 5g (5%)

[0077] Solid Lipid 6g(6%)

[0078] Liquid Lipid 8g(8%)

[0079] Solid emulsifier 6g (6%)

[0080] Additive 2g (2%)

[0081] Preservatives 0.2g (0.2%)

[0082] The balance is deionized water;

[0083] The solid sunscreen is benzophenone-3;

[0084] The liquid sunscreen is octyl salicylate;

[0085] Described solid lipid is glyceryl tristearate;

[0086] Described liquid lipid is isopropyl palmitate;

[0087] Described solid emulsifier is ceteareth-30;

[0088] Described additive is potassium chloride;

[0089] Described preservative is phenoxyethanol.

[0090] The preparation method of the above-mentioned solid lipid sunscreen particles coated with sunscreen is the same as in Example 1.

Embodiment 3

[0092] A solid lipid sunscreen granule coated with a sunscreen, calculated according to the total amount of 100g, its composition and content are as follows:

[0093] Solid sunscreen 8g (8%)

[0094] Liquid sunscreen 6g (6%)

[0095] Solid Lipid 10g(10%)

[0096] Liquid Lipid 13g(13%)

[0097] Solid emulsifier 8g (8%)

[0098] Additive 10g(10%)

[0099] Preservatives 0.5g (0.5%)

[0100] The balance is deionized water;

[0101] Described solid sunscreen is ethylhexyl triazone;

[0102] The liquid sunscreen is 2-cyano-3,3-octyl diphenylacrylate;

[0103] Described solid lipid is glyceryl tristearate;

[0104] The liquid lipid is isooctyl palmitate;

[0105] Described solid emulsifier is ceteareth-25;

[0106] The additive is 1,3-butanediol;

[0107] The preservative is diazolidinyl urea.

[0108] The preparation method of the above-mentioned solid lipid sunscreen particles coated with sunscreen is the same as in Example 1.

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Abstract

The invention discloses a sun screening agent-coated solid lipid sunscreen particle and a preparation method thereof. The sun screening agent-coated solid lipid sunscreen particle comprises the following components by weight: 1-15% of solid sun screening agents, 3-18% of liquid sun screening agents, 2-20% of solid lipid, 3-20% of liquid lipid, 3-15% of solid emulsifiers, 0.5-20% of additives, 0.01-0.8% of preservatives, and the balance being deionized water. The preparation method comprises the following steps: fusing and uniformly dispersing an oil phase composed of solid lipid, liquid lipid, emulsifiers and sun screening agents at 65-95 DEG C to obtain the oil phase, heating a water phase composed of additives and deionized water to 65-95 DEG C, homogenizing the water phase, adding the oil phase into the water phase, uniformly mixing, performing ultrasonic treatment, and finally stirring and cooling to room temperature to obtain the sun screening agent-coated solid lipid sunscreen particle.

Description

technical field [0001] The invention relates to a solid lipid sunscreen particle coated with a sunscreen and a preparation method thereof. Background technique [0002] Solid lipid nanoparticles (SLN), also known as solid liposomes, are solid particles formed by solidification and crystallization of solid fat during cooling or phase separation. As a new type of carrier, solid lipid nanoparticles have the advantages of good physiological compatibility, biodegradability, strong drug loading capacity, stable physical and chemical storage, low cost, and large-scale production. When used in cosmetics, it can enhance the permeability and targeting of active ingredients, improve the closure effect and hydration, and at the same time, as a coating carrier, it can improve the stability of active ingredients. [0003] Sunscreen has always been a topic of concern in the field of cosmetics, and the stability, safety, and effectiveness of sunscreens are issues that must be solved for su...

Claims

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Application Information

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IPC IPC(8): A61K8/14A61K8/92A61Q17/04
Inventor 张婉萍朱海洋刘晓慧
Owner SHANGHAI INST OF TECH
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