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A kind of faropenem sodium granule and preparation method thereof

A technology of faropenem sodium and granules, applied in the field of medicine, can solve problems such as no mention of drug stability, no creative technical inventions, etc., and achieve the effects of good drug stability, simple production process, and avoidance of contraindications

Inactive Publication Date: 2016-02-03
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] CN101744782B discloses a tablet containing faropenem sodium, but does not mention how to improve the stability of the drug, and no creative technical inventions are found in the examples

Method used

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  • A kind of faropenem sodium granule and preparation method thereof
  • A kind of faropenem sodium granule and preparation method thereof
  • A kind of faropenem sodium granule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Faropenem Sodium 250g

[0030] Hydroxypropyl Beta Cyclodextrin 250g

[0031] 45% ethanol aqueous solution appropriate amount

[0032] Sucrose 400g

[0033] Aspartame 2g

[0034] Sweet Orange Flavor 4g

[0035] Preparation Process

[0036] Hydroxypropyl beta-cyclodextrin and faropenem sodium were passed through a 100-mesh sieve, mixed uniformly, granulated by adding 45% ethanol solution, extruded into strip-shaped granules by an extruder, spheronized to obtain drug-containing pellets, dried and homogeneously passed through 60 Mix the sucrose, aspartame and sweet orange essence sieved with mesh sieve and pack it.

Embodiment 2

[0038] Faropenem Sodium 250g

[0039] Hydroxypropyl Beta Cyclodextrin 1000g

[0040] 85% ethanol aqueous solution appropriate amount

[0041] Mannitol 500g

[0042] Stevia 2g

[0043] Coconut Flavor 3g

[0044] Preparation Process

[0045] Hydroxypropyl beta-cyclodextrin and faropenem sodium were passed through a 100-mesh sieve, mixed uniformly, granulated by adding 45% ethanol solution, extruded into strip-shaped granules by an extruder, spheronized to obtain drug-containing pellets, dried and homogeneously passed through 60 Mesh sieved mannitol, stevia, and coconut essence are mixed and packaged.

Embodiment 3

[0047] Faropenem Sodium 250g

[0048] Hydroxypropyl Beta Cyclodextrin 625g

[0049] 55% ethanol aqueous solution appropriate amount

[0050] Sucrose 500g

[0051] Aspartame 2g

[0052] Coconut Flavor 3g

[0053] Preparation Process

[0054] Hydroxypropyl beta-cyclodextrin and faropenem sodium were passed through a 100-mesh sieve, mixed uniformly, granulated by adding 55% ethanol solution, extruded into strip-shaped granules with an extruder, spheronized to obtain drug-containing pellets, dried and homogeneously passed through 60 Mix the sucrose, aspartame and coconut essence sieved with a mesh screen and pack it.

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Abstract

A faropenem sodium granule and a preparation method thereof, which are prepared by the following method: uniformly mixing faropenem sodium and hydroxypropyl beta-cyclodextrin, adding an aqueous solution of ethanol to granulate, extruding, spheronizing, drying, and then combining with pharmaceutically acceptable The accepted auxiliary materials are mixed evenly and packaged.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a faropenem sodium granule and a preparation method thereof. Background technique [0002] Faropenem is an atypical β-lactam antibiotic, which is a derivative of penems. Two types of compounds, carbapenems and penems, have attracted great interest. Penems have more unique advantages. Currently, five penem derivatives are under development, and faropenem is convenient. is one of them. In addition to being weak against Pseudomonas aeruginosa, it has a broad antibacterial spectrum and is particularly effective against anaerobic bacteria, which is better than carbapenem antibiotics. It shows broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive bacteria and Gram-negative bacteria, especially against drug-resistant Staphylococcus, Enterococcus and other Gram-positive bacteria and Bacteroides and other anaerobic bacteria All are superior to e...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K31/431A61K47/40A61P31/04
Inventor 沈若武张蓓孙勇徐晟伟夏玉军晁凡赵成管文敏
Owner QINGDAO UNIV