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Preparation method of Huixinkang tablets and application thereof in anus sarcoma cell S-180 cell proliferation inhibition drugs

A technology of Huixinkang and Huixincao, which is used in drug combinations, antitumor drugs, and medical preparations containing active ingredients, etc., can solve the problems of large patient dosage, many impurities, and rough process, so as to achieve a small dosage, The effect of reducing the dosage and taking the dosage without bitter taste

Inactive Publication Date: 2014-10-15
关军
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on Huixinkang Capsules using supercritical and microwave technology in the extraction and preparation. However, the traditional Chinese medicine is directly powdered and decocted in water. The process is rough and backward, and there are many impurities, which leads to excessive dosage for patients. It is convenient to take, which seriously affects the clinical application of this product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Take 780g of Uncaria vine, 910g of Huixincao, 26g of Polygonum multiflorum, 260g of Astragalus, 26g of Radix Notoginseng, 650g of Hawthorn, 260g of Licorice. 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer to the total extraction solvent is 5%, the extraction pressure is 25MPa, the temperature is 40°C, and the CO 2 The flow rate is 2ml / g crude drug·min, the extraction time is 200min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, pulverized, added 10L of 60% ethanol, and put into a microwave extraction device for microwave extraction, with an extraction power of 700W, for 2 extractions. Each time for 8 minutes, the extracts were combined, concentrated, added to a D101 macroporous adsorption resin column, eluted with 60% ethanol, collected 5 times the column volume eluate, recovered ethanol under reduced pressure, concentrated and dried to obtain a micr...

Embodiment 2

[0034] Take 780g of Uncaria vine, 910g of Huixincao, 26g of Polygonum multiflorum, 260g of Astragalus, 26g of Radix Notoginseng, 650g of Hawthorn, 260g of Licorice. 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 4%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3ml / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, pulverized, added 10L of 60% ethanol, and put into a microwave extraction device for microwave extraction, with an extraction power of 600W, and extracted twice. Combine extracts for 5 minutes each time, concentrate, add to D101 macroporous adsorption resin column, elute with 60% ethanol, collect 5 times column volume eluate, recover ethanol under reduced pressure, concentrate and dry to obtain microwave extract , for later u...

Embodiment 3

[0037] Take 780g of Uncaria vine, 910g of Huixincao, 26g of Polygonum multiflorum, 260g of Astragalus, 26g of Radix Notoginseng, 650g of Hawthorn, 260g of Licorice. 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer to the total extraction solvent is 6%, the extraction pressure is 15MPa, the temperature is 30°C, and the CO 2 The flow rate is 1ml / g crude drug·min, the extraction time is 220min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, crushed, added 10L of 60% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 800W, and the extraction is performed twice. For 10 minutes each time, combine the extracts, concentrate, add to the D101 macroporous adsorption resin column, elute with 60% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, concentrate and dry to obtain the mic...

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Abstract

The invention belongs to the technical field of traditional Chinese medicine, particularly to a preparation method of Huixinkang tablets and application thereof. According to the preparation method of Huixinkang tablets, the Huixinkang tablets provided by the invention are prepared through adopting supercritical fluid extraction and microwave-assisted extraction of the following components as the pharmaceutical raw materials: 780 g of uncaria, 910 g of red rhodobryum, 26 g of polygonum multiflorum, 260 g of astragalus membranaceus, 26 g of panax notoginseng, 650 g of hawthorn and 260 g of glycyrrhiza, so that the ginsenoside Rg1 content is greatly increased through adopting the method. The invention further provides the application of the Huixinkang tablets in the preparation of anus sarcoma cell S-180 cell proliferation inhibition drugs.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a preparation method of Huixinkang Tablet and its application in medicines for inhibiting the proliferation of mouse anal sarcoma cells S-180 cells. Background technique [0002] The standard number of Huixinkang Capsules is WS-10737 (ZD-0737)-2002, which is recorded in the Department of Internal Medicine and Heart Department of the National Compilation of Chinese Patent Medicine Standards. It is made from 780g of Uncaria chinensis, 910g of Huixincao, 26g of Polygonum multiflorum, 260g of astragalus, 26g of Panax notoginseng, 650g of hawthorn, and 260g of licorice. For qi deficiency and blood stasis, hyperactivity of liver yang caused by chest obstruction, dizziness, symptoms such as chest obstruction, chest tightness, palpitations, dizziness, coronary heart disease, hypertension belonging to the above syndromes. [0003] In the prior art, there...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/74A61K9/20A61P35/00
Inventor 关军
Owner 关军
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