Method for detecting chaetoglobosin concentration in blood plasma

A technique for chaetoglobins A and plasma, which is applied in the directions of measuring devices, instruments, scientific instruments, etc., can solve the problems such as the in vivo determination method of Chaetoglobins A, literature reports, etc., and achieves a simple pretreatment method, strong specificity, and easy operation. Effect
CN104101665AInactive Publication Date: 2014-10-15JIANGSU PROVINCIAL HOSPITAL OF TCM
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
JIANGSU PROVINCIAL HOSPITAL OF TCM
Publication Date
2014-10-15
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a method for detecting chaetoglobosin concentration in blood plasma. The method adopts a liquid chromatography tandem mass spectrometry system to perform detection, a sample to be detected is firstly taken, a certain amount of organic menstruum protein precipitant is added to perform protein precipitation, and detection is performed through chromatographic column separation and a mass spectrum detector after pretreatment. The method is quick, accurate, high in sensitivity, simple and convenient to operate and suitable for concentration detection in the blood plasma.
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Description

technical field

[0001] The invention belongs to the technical field of biological detection, and in particular relates to a method for measuring the concentration of chocolin A in blood plasma. Background technique

[0002] Chaetoglobins A (Chaetoglobins A) is a new alkaloid compound isolated from the endophytic fungus Chaetomium globosum of the medicinal plant Imperata imperina. In vitro experiments have proved that Chaetoglobins A has significant anti-tumor effects, can inhibit the expression of proto-oncogenes and the proliferation of cancer cells, and has obvious inhibitory effects on human breast cancer cell line MCF-7 and colon cancer cell line SW1116. It is a promising development prospect. new drug source compounds. Its structural formula is as follows:

[0003]

[0004] There are no literature reports on the in vivo assay of Chaetoglobins A. The present invention establishes a method for measuring Chaetoglobins A in rats, and conducts exploratory research on t...

Claims

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