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A kind of sprayable metronidazole gel composition

A kind of technology of nidazole gel and composition, applied in the field of sprayable metronidazole gel composition, can solve problems such as composition stickiness, inability to spray, influence on stability of sprayable gel composition and the like

Active Publication Date: 2018-12-11
JIANGSU SEMPOLL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Composition may become too viscous to spray
The composition may also become too thin, runny or drip
Phase separation may also occur resulting in an inappropriate concentration of the active ingredient to be released
Stability of sprayable gel compositions can be adversely affected by the addition of active ingredients to the composition
[0008] In addition, in inflammatory papules, pustules, and rosacea erythema, there are often body fluids or pus oozing out, which contain a certain amount of salt, and the salt can affect the stability of the gel through salting out and change its performance. affect its clinical efficacy

Method used

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  • A kind of sprayable metronidazole gel composition
  • A kind of sprayable metronidazole gel composition
  • A kind of sprayable metronidazole gel composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031]

Embodiment 2

[0033]

Embodiment 3

[0035]

[0036] Preparation:

[0037] Dispersions of the above samples were prepared in stainless steel vessels equipped with stirrers. Add carboxymethyl cellulose sodium and λ-type carrageenan to water and stir vigorously to form a uniform dispersion system, then add glycerin and PEG and stir evenly, after mixing, add ethanol, the main drug (and possibly other ingredients), and finally add water to a sufficient amount (100%), and stir until a uniform dispersion is obtained. Finally transfer this final product into a pump spray container.

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PUM

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Abstract

The invention discloses a sprayable metronidazole gel composition. The composition comprises metronidazole, water, a water-miscible solvent, carboxymethyl cellulose, gamma-carrageenan and PEG12000-20000. The gel composition is high in physical stability, stronger in salt resistance capability and convenient to use.

Description

【Technical field】 [0001] The invention relates to a sprayable metronidazole gel composition. Specifically, it relates to a sprayable metronidazole gel composition with physical stability and strong salt resistance. 【technical background】 [0002] Metronidazole can be used as a topical external drug for the local treatment of inflammatory papules, pustules and rosacea erythema, and related lotions and gel preparations are commercially available. [0003] Commercially available lotion preparations are generally in liquid form and are sprayed or rubbed onto the affected areas of the skin. Liquids used for spraying generally have a viscosity similar to water. This means that sprayable liquids generally spread too easily, dripping from sprayed skin and staining clothing. [0004] Commercially available gel formulations are generally semi-solid gels. This gel is very viscous. High viscosity is desired when the composition is to prevent running or dripping. Gels are usually a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K31/4164A61K47/38A61K47/36A61K47/10A61P17/00A61P31/04
Inventor 王学政张新明尤斌周越强
Owner JIANGSU SEMPOLL PHARMA