Preparation method of biological active hydroxylamine oxalate vanadium complex crystal

Abstract

The invention discloses a preparation method of a biological active hydroxylamine oxalate vanadium complex crystal, and the method uses Rb <+ >ions as external balance ions for participating into the complex, and comprises the following steps: 1, at 0-4 DEG C, rubidium carbonate, ammonium metavanadate, oxalic acid, hydroxylamine hydrochloride and water are stirred and dissolved in a container I, the pH value of the solution is adjusted by a hydrochloric acid solution to obtain a pale yellow clear solution; 2, anhydrous alcohol is added into another container II, the container I filled with the reaction liquid in the step 1 is put in the container II, the container II is sealed, and placed in a refrigerator for standing for 2 to 4 days, and a colorless flaky crystal is precipitated on the container I bottom; and 3, the crystal precipitated on the container I bottom is taken out, washed with deionized water for a plurality of times, then is successively washed respectively with the anhydrous ethanol and ether for a plurality of times, and then is put in a dryer to obtain dry and pure crystal, namely the biological active hydroxylamine oxalate vanadium complex crystal. The obtained biological active hydroxylamine oxalate vanadium complex crystal is good in biological activity, and the preparation method is simple, easy in operation, and short in time.

Description

technical field

[0001] The invention relates to a preparation method of crystals, in particular to a preparation method of biologically active hydroxylammonium oxalate vanadium complex crystals. Background technique

[0002] Vanadium is an essential trace element in some animals, and may play a very important role in the metabolism of glucose. Studies have found that some complexes of inorganic vanadate and vanadium organic ligands have good insulin-like activity. A small number of vanadium compounds have been put into clinical trials. Inorganic vanadate has high toxicity, low fat solubility, low bioavailability, and large dosage, so its absorption and utilization rate in organisms is low, and a large amount of use has great toxic and side effects, thus affecting its use in medicine. wide range of applications in the field. In view of this, it is very important to increase the bioavailability of vanadium compounds and reduce their toxicity. A common method to solve these p...