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Mouth wash and preparation method thereof

Mouthwash and formulation technology, which is applied in oral care, pharmaceutical formulations, cosmetic preparations, etc., can solve problems such as safety hazards, inability to remove bacterial deposits, oral microbial balance disorders, etc., to prevent tooth decay, prevent and treat periodontal Inflammation, the effect of simple preparation steps

Inactive Publication Date: 2014-12-10
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most existing mouthwashes add bacteriostatic agents. Although the use of bacteriostatic agents can play a role in removing oral bacteria, they cannot remove the bacterial deposits present in plaque and calculus, and may still cause periodontitis. develop
On the other hand, the long-term use of antibacterial agents may also cause the balance of oral microorganisms to be disturbed, causing other safety hazards

Method used

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  • Mouth wash and preparation method thereof
  • Mouth wash and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The sum of the mass percentages of the following components is 100%:

[0028] components

[0029] Preparation method: Add 0.05% aspartame and 0.15% mint essence into water and stir until dissolved, then add 6% glycerin to the aqueous solution, stir evenly to form a uniformly dispersed clear liquid; then add 0.6% sodium fluoride and 0.35% Human serum albumin continued to stir, and after mixing evenly, 0.1% Toll-like receptor 4 neutralizing antibody was added and stirred until evenly mixed; the finished product was obtained by filtering with a filter membrane (0.8 micron), and stored at 4°C.

Embodiment 2

[0031] The sum of the mass percentages of the following components is 100%:

[0032] components

[0033] Preparation method: Add 0.1% xylitol and 0.2% green tea essence into water and stir until dissolved, then add 3% sorbitol to the aqueous solution, stir evenly to form a uniformly dispersed clear liquid; then add 0.8% potassium fluoride and 0.4% Human serum albumin continued to stir, and after mixing evenly, 0.2% Toll-like receptor 4 neutralizing antibody was added and stirred until evenly mixed; the finished product was obtained by filtering with a filter membrane (0.8 micron), and stored at 4°C.

Embodiment 3

[0035] The sum of the mass percentages of the following components is 100%:

[0036] components

[0037] Preparation method: Add 0.05% sodium saccharin and 0.2% peppermint essence into water and stir until dissolved, then add 6% mannitol into the aqueous solution, stir evenly to form a uniformly dispersed clear liquid; then add 0.7% sodium monofluorophosphate and 0.3% Human serum albumin continued to stir, and after mixing evenly, 0.02% Toll-like receptor 4 neutralizing antibody was added and stirred until evenly mixed; the finished product was obtained by filtering with a filter membrane (0.8 micron), and stored at 4°C.

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PUM

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Abstract

The invention relates to mouth wash and a preparation method thereof. The mouth wash comprises a Toll-like receptor 4 neutralizing antibody, an antibody stabilizer, a sweetening agent, scented water, a wetting agent, an anti-caries agent, deionized water, and other components. The preparation method of the mouth wash is simple. According to the mouth wash, medicine is locally used, and the effect of cutting off cell wall lipopolysaccharide is performed to inhibit inflammation and antagonize the weakening of osteogenic differentiation capacity of periodontal ligament stem cells, so as to reach the purpose of treating gingivitis and periodontitis; and meanwhile, the mouth wash has the effects of cleaning the mouth, preventing the dentes cariosus, and freshening the breath.

Description

technical field [0001] The invention belongs to a health care product, in particular to a mouthwash for preventing and treating periodontitis and a preparation method thereof. Background technique [0002] Periodontitis is a common oral disease. According to the statistics of the World Health Organization, about 90% of people have periodontitis. Its pathological characteristics are the loss of periodontal attachment and the recession of alveolar bone. The lesion process involves gums, alveolar bone, The supporting tissues of teeth such as periodontal ligament and cementum eventually lead to tooth loss, which brings great pain to patients. [0003] As an oral health product, mouthwash can be used as an auxiliary treatment for periodontitis. However, most existing mouthwashes add bacteriostatic agents. Although the use of bacteriostatic agents can play a role in removing oral bacteria, they cannot remove the bacterial deposits present in plaque and calculus, and may still cau...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/64A61K8/21A61Q11/00A61P1/02
Inventor 李蓓金岩董智伟张勇杰周峻刘源李成华
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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