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Application of berberine in preparation of medicine for treating ovulation disorder infertility

A technology of infertility and berberine, applied in the field of medicine, can solve problems such as unfavorable long-term use, liver and kidney function damage, and high price

Active Publication Date: 2017-12-12
吴效科
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to overcome the relatively large side effects (such as: multiple pregnancy, ovary enlargement, ovarian cyst rupture, ovarian hyperstimulation syndrome, arterial thromboembolism, hot flashes, heating and liver and kidney disease) that existing ovulation-stimulating drugs exist. functional impairment, etc.), and the price is expensive, the curative effect is general, and is not conducive to shortcomings such as long-term use, thereby providing a new drug that can be used for the treatment of ovulatory infertility, that is, berberine (trade name berberine)

Method used

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  • Application of berberine in preparation of medicine for treating ovulation disorder infertility

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Embodiment 1

[0009] Application of embodiment 1 berberine (berberine) in the preparation of the medicine for the treatment of ovulation disorder infertility

[0010] 1. Inclusion criteria of clinical cases

[0011] ①Women of childbearing age have normal sexual life after marriage, the man’s reproductive function is normal, and they live together without contraception for 1 year but fail to conceive. Primary infertility refers to those who have never conceived after marriage; Those who have not conceived without contraception and have not conceived for more than one year.

[0012] ②Diagnostic criteria for follicular maturation disorder and anovulation: ①The basal body temperature has been recorded continuously for more than 3 months in monophasic or atypical biphasic phase; Ovulation cycle of small follicle: follicle diameter > 14mm, but 30mm, unruptured follicle luteinized). There was no secretion peak in urine LH determination.

[0013] ③ There are childbearing requirements.

[0014]...

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Abstract

Disclosed is a use of berberine in the preparation of drugs for treating ovulatory dysfunction infertility. The berberine induces ovulation of a patient, and reduces the probability of a multiple pregnancy, pregnancy complications and adverse reactions such as nausea, vomit, constipation and diarrhea.

Description

technical field [0001] The invention relates to a new use of berberine, in particular to the use of berberine in the preparation of medicines for treating ovulatory infertility. The invention belongs to the technical field of medicine. Background technique [0002] Infertility is a common disease in gynecology with complex etiology. Ovulation disorder is one of the main causes of female infertility, accounting for 25%-35% of infertility. Western medicine believes that the reasons for anovulation are as follows: ① Hypogonadism caused by hypothalamic-pituitary failure, which is characterized by blood luteinizing hormone (Luteinizing Hormone, LH), follicle-stimulating hormone (FSH) ) and low estrogen levels; ②Hypothalamic-pituitary dysfunction: It is characterized by abnormal gonadotropin LH / FSH secretion ratio, such as polycystic ovary syndrome, abnormal increase in the frequency and amplitude of LH secretion, and relatively insufficient FSH secretion, resulting in Blood LH / ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4375A61P15/08
CPCA61K31/4375
Inventor 吴效科张跃辉马红丽沈文娟李瑞丽
Owner 吴效科
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