Phenylacetylglutamine as a biomarker of healthy aging

A technology of glutamine and phenylacetyl, which is applied in the application field of improvement, can solve the problems such as the comprehensive description of the molecular mechanism that has not yet been reported, and the lack of long-lived metabolic phenotype research.

Inactive Publication Date: 2017-06-13
NESTEC SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Despite these findings, a comprehensive delineation of the molecular mechanisms influencing the aging process has yet to be reported
Furthermore, metabolic phenotype studies on longevity are still lacking

Method used

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  • Phenylacetylglutamine as a biomarker of healthy aging
  • Phenylacetylglutamine as a biomarker of healthy aging
  • Phenylacetylglutamine as a biomarker of healthy aging

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0136] Subjects and Study Groups

[0137] Each individual and their family gave informed consent for the study to be conducted. In total, in northern Italy (including Bologna, Florence, Parma, Milan), 541 subjects belonging to different age groups were enrolled for this study. The centenarian group consisted of 156 individuals (125 females and 31 males), the older group consisted of 363 individuals (205 females and 158 males), and the young adult group consisted of 22 individuals (10 women and 12 men).

[0138] The study protocol was approved by the ethics committee of the Sant'Orsola-Malpighi University School of Medicine (Bologna, Italy). The resulting biological samples (serum and urine) were stored at -80°C prior to metabolomic analysis.

[0139] clinical chemistry

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Abstract

Using NMR / MS-based metabolomics and targeted lipidomics approaches, the inventors studied the metabolic phenotypes of aging and longevity in a cohort including centenarians, older adults, and young adults. The present inventors have identified biomarkers for the reduced risk of developing age-related chronic inflammatory conditions, proposing that the use of phenylacetylglutamine (PAG) as a biomarker diagnosis allows delaying and / or avoiding the life of aging-related chronic inflammatory conditions. way of in vitro methods.

Description

technical field [0001] The present invention generally relates to healthy lifestyles and the prevention of age-related chronic conditions. In particular, the invention relates to biomarkers and their use in detecting lifestyle improvements. Thus, the present invention provides, for example, phenylacetylglutamine (PAG) as a biomarker, and also a method of using the biomarker phenylacetylglutamine to diagnose a lifestyle that allows delaying and / or avoiding aging Associated chronic inflammatory conditions. Background technique [0002] Aging is defined as a time-dependent decline in functional capacity and stress resistance, associated with increased risk of morbidity and mortality. Furthermore, the human aging phenotype is very heterogeneous and can be described as a complex mosaic resulting from the interaction of various environmental, stochastic and genetic-epigenetic variables. Decades of aging research have uncovered hundreds of genes and many biological processes ass...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/68
CPCG01N33/6893Y10T436/200833Y10T436/24Y10T436/182G01N2800/60Y10T436/203332Y10T436/173845G01N2800/7095G01N33/6848G01N2800/50G01N33/6842G01N2800/7042G01N33/54306
Inventor S·科里诺I·蒙托柳 鲁拉F-P·马丁P·A·盖S·A·D·莱兹
Owner NESTEC SA
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