Nano biopesticide composition and preparation method thereof

A biopesticide and composition technology, applied in botany equipment and methods, chemicals for biological control, biocides, etc., can solve the problems of low effective utilization rate of pesticides, large amount of organic solvents, etc., and achieve good control Good effect, long-lasting effect, simple and easy preparation method

Inactive Publication Date: 2015-01-07
李晓枫
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] In recent years, in order to solve the problems of large amount of organic solvents and low effective utilization rate of pesticides in traditional pesticide formulations, research and development of new pesticide formulations with slow and controlled release, targeted deposition and environmental compatibility have become the development trend of pesticide formulation processing.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] (1) 20 mg of amphiphilic polymer (polyethylene glycol monomethyl ether-polylactic acid-glycolic acid, mPEG-PLGA, purchased from Jinan Daigang Biotechnology Co., Ltd., the monopolyethylene glycol methyl ether-poly The hydrophilic group of the lactic acid-glycolic acid copolymer is a polyethylene glycol monomethyl ether group, and the hydrophobic group is a polylactic acid-glycolic acid group, and the polyethylene glycol monomethyl ether-polylactic acid-glycolic acid copolymerization The arrangement of the repeating units of the compound is block type, and the molecular weight is 2.5×10 4 ) and 2 mg of hydrophobic drug (hexaconazole) were dissolved in 1 mL of organic solvent (dichloromethane) to obtain the first solution; hydrophilic drug (Jinggangmycin) was dissolved in water to obtain a concentration of 40 mg / mL drug solution to obtain a second solution; 200 μL of the second solution was added to the first solution, and ultrasonic emulsification was performed at a power...

Embodiment 2

[0025] This embodiment prepares the nanobiological pesticide composition according to the same method as Example 1, the difference is that the concentration of hexaconazole in the first solution is 10 mg / mL, and the concentration of Jinggangmycin in the second solution is It is 0.01 mg / mL.

[0026] According to the same measurement method as in Example 1, the particle diameter of the nano-bio-pesticide composition obtained in this embodiment is 274.2nm by using a laser particle size analyzer; it is recorded that 0.07 mg of hexaconazole is contained in every gram of nano-bio-pesticide composition, Jinggangmycin 0.035 micrograms.

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Abstract

The invention relates to a nano biopesticide composition and a preparation method thereof. The preparation method comprises the following steps: (1) mixing and emulsifying a first solution with a second solution to obtain a first emulsion, wherein the first solution contains an amphiphilic polymer, a hydrophobic pesticide and an organic solvent, and the second solution contains a hydrophilic pesticide and water; (2) mixing and emulsifying the first emulsion obtained in the step (1) with a third solution containing an emulsifying agent and water to obtain a second emulsion; and (3) removing an organic solvent in the second emulsion obtained in the step (2), and separating to obtain the nano biopesticide composition. According to a principle of forming an oil / water-in-water nano-micelle from the amphiphilic polymer through a double-emulsion method, the hydrophilic pesticide and the hydrophobic pesticide are entrapped in different layers of a nano-capsule respectively, thus realizing co-loading of the hydrophilic pesticide and the hydrophobic pesticide. Through a simple and easy method, a problem of combining the hydrophilic pesticide and the hydrophobic pesticide in the nano biopesticide is solved.

Description

technical field [0001] The invention relates to a pesticide composition and a preparation method thereof, in particular to a nanobiological pesticide composition and a preparation method thereof. Background technique [0002] In recent years, in order to solve the problems of large amount of organic solvent and low effective utilization rate of pesticides in traditional pesticide formulations, research and development of new pesticide formulations with slow and controlled release, targeted deposition and environmental compatibility have become the development trend of pesticide formulation processing. . Pesticide sustained and controlled release system is one of the main new dosage forms at present, mainly including nanocapsules and microcapsules. Compared with microcapsules, nanocapsules have smaller particle size and better passive targeting; Permeability is better. [0003] One of the main choices for nanosized drug carriers is amphiphilic polymers, which have hydrophil...

Claims

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Application Information

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IPC IPC(8): A01N25/10A01N25/28A01N43/653A01P3/00A01N43/16
Inventor 李晓枫
Owner 李晓枫
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