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Lsine hydrochloride and zinc gluconate composite particle and sugar-free type lysine and zinc gluconate particle

A technology of zinc gluconate and lysine hydrochloride, which can be used in drug combinations, medical preparations with inactive ingredients, metabolic diseases, etc., can solve the problem of not granting patent rights, etc., and achieve small differences in weight ratio and good compliance. , the effect of uniform content

Inactive Publication Date: 2015-01-07
谢鹏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the addition of a binder in this patent compared with the prior art, it is well known that the function of the binder is to help the granule formability when preparing granules, so as to improve the granulation and granule strength of the granules. and granule fluidity, and the beneficial technical effect presented by the above patent of Hainan Huigu Pharmaceutical Co., Ltd. is also the beneficial effect that the binder can impart to the granule, that is, to improve the granulation, granule strength and granule flow of the granule Therefore, the invention patent 201410241825.2 (CN103976992A) applied by Hainan Huigu Pharmaceutical Co., Ltd. should not be granted a patent right

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] In the embodiment of the present invention, a composite particle of lysine hydrochloride and zinc gluconate comprises:

[0041] Lysine hydrochloride 125g,

[0042] Zinc gluconate 35 g,

[0043] Xylitol 791g,

[0044] Stevia 10g,

[0045] citric acid 12.5 g,

[0046] 18% povidone K30 23.5 g,

[0047] Cantaloupe Flavor 5.0.

[0048] After all raw and auxiliary materials are crushed separately, pass through a 60-mesh sieve, and mix with 18% povidone K30 aqueous solution; after the solid powder is uniformly mixed by an equal-volume incremental method, use the povidone K30 aqueous solution as a binder to make a soft material; 16-mesh sieve Granulate, oven-dry at 55-65°C, granulate with a 16-mesh sieve, add essence in proportion, and mix well. The particle size of the prepared particles was 6%, the strength of the particles was 19N, the Carr index was 16%, and the angle of repose was 26°.

Embodiment 2

[0050] In the embodiment of the present invention, a composite particle of lysine hydrochloride and zinc gluconate comprises:

[0051] Lysine hydrochloride 130g,

[0052] Zinc gluconate 37g,

[0053] Dextrin 787.5g,

[0054] Aspartame 5g,

[0055] Citric acid 10g,

[0056] Povidone K30 20g,

[0057] Sweet orange essence 5g,

[0058] After all the raw and auxiliary materials are respectively pulverized, pass through a 65-mesh sieve, and mix with 18% povidone K30 aqueous solution; after the solid powder is uniformly mixed by an equal-volume incremental method, use the povidone K30 aqueous solution as a binder to make a soft material; 16-mesh sieve Granulate, dry in an oven at 60°C, sieve through a 16-mesh sieve, add essence in proportion, and mix well. The particle size of the prepared particles was 7%, the strength of the particles was 20N, the Carr index was 17%, and the angle of repose was 32°.

Embodiment 3

[0060]In the embodiment of the present invention, a composite particle of lysine hydrochloride and zinc gluconate comprises:

[0061] Lysine hydrochloride: 100g,

[0062] Zinc gluconate 30g,

[0063] Lactose 788g,

[0064] Stevia 12g,

[0065] Tartaric acid 50g,

[0066] Povidone K30 15g,

[0067] Strawberry essence 10g,

[0068] After all the raw and auxiliary materials are respectively pulverized, pass through a 65-mesh sieve, and mix with 18% povidone K30 aqueous solution; after the solid powder is uniformly mixed by an equal-volume incremental method, use the povidone K30 aqueous solution as a binder to make a soft material; 16-mesh sieve Granulate, dry in an oven at 60°C, sieve through a 16-mesh sieve, add essence in proportion, and mix well. The particle size of the prepared particles was 8%, the strength of the particles was 18N, the Carr index was 18%, and the angle of repose was 31°.

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Abstract

The invention discloses an lsine hydrochloride and zinc gluconate composite particle and a preparation method thereof. The lsine hydrochloride and zinc gluconate composite particle comprises the following components in parts by weight: 10-15 parts of lysine hydrochloride, 3-4 parts of zinc gluconate, 0.5-2 parts of sweetening agent, 1.0-2.5 parts of citric acid, 60-90 parts of filling agent, 3-5 parts of povidone K30 and 0.5-1.0 part of essence. The invention also discloses a sugar-free type lysine and zinc gluconate particle, the sugar-free type lysine and zinc gluconate particle / 10000 g comprises the following components by weight: 125 g of lysine hydrochloride, 35 g of zinc gluconate, 12.5 g of citric acid, 5 g of stevioside and 822.5 g of dextrin. The sugar-free type lysine and zinc gluconate particle disclosed by the invention is particularly suitable for diabetics.

Description

technical field [0001] The invention relates to a composite granule of lysine hydrochloride and zinc gluconate, a sugar-free zinc lysine gluconate granule and a preparation method thereof. Background technique [0002] Lysine is an indispensable and important element in children's growth and development; lack of appetite, slow growth, and mental retardation. Zinc gluconate is one of the important substances in the living body; during the growth of children, zinc deficiency often occurs; when lacking, anorexia, loss of appetite, listlessness, and developmental delay. In addition, lysine and zinc are also necessary for adults. [0003] According to the existing national prescription, the lysine hydrochloride and zinc gluconate granules are composed of 2.5% lysine hydrochloride, 0.7% zinc gluconate, 0.25% citric acid and 96.55% sucrose according to weight percentage. In particular, no adhesives are used in this existing national prescription. [0004] It is found through res...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/315A61K9/16A61K47/26A61K47/36A61P3/02A61K31/198
Inventor 谢鹏
Owner 谢鹏
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