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Traditional Chinese medicine composition and application thereof to preparation of nephrotic syndrome treating drug

A technology of composition and traditional Chinese medicine, applied in the directions of drug combination, pharmaceutical formula, plant raw material, etc., can solve the problems of large side effects, easy recurrence, low effective rate of nephrotic syndrome treatment, etc.

Active Publication Date: 2015-01-07
石家庄合泰恒医院股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The purpose of the present invention is to provide a Chinese medicine composition for treating nephrotic syndrome, so as to solve the problems of low effective rate, large side effects and easy recurrence in the prior art for treating nephrotic syndrome

Method used

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  • Traditional Chinese medicine composition and application thereof to preparation of nephrotic syndrome treating drug
  • Traditional Chinese medicine composition and application thereof to preparation of nephrotic syndrome treating drug
  • Traditional Chinese medicine composition and application thereof to preparation of nephrotic syndrome treating drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1 clinical trial

[0024] (1) Case selection

[0025] From May 2010 to May 2013, 60 patients with nephrotic syndrome were screened, all of whom had clinical manifestations such as edema, massive proteinuria, and hypoalbuminemia in varying degrees, and the laboratory test results indicated that the urine protein exceeded 3.5g / 24h , plasma albumin is lower than 30g / L, which meets the diagnostic criteria in the 2003 "Discussion Minutes of Kidney Disease Diagnosis, Treatment and Curative Effect Standards", and excludes secondary diseases caused by systemic lupus erythematosus, diabetes, hypertension, purpura nephritis, etc. nephrotic syndrome.

[0026] (2) Case information

[0027] A total of 60 patients were included in the observation, aged between 22-61 years, with a course of disease ranging from 7-96 months. They were grouped according to the random number form blind method, with 30 cases in the test group and 30 cases in the control group. In the test gr...

Embodiment 2

[0051] Example 2 Clinical Trials

[0052] (1) Case selection

[0053] From February 2010 to January 2014, 108 patients with nephrotic syndrome were selected as observation objects, and the screening criteria were the same as in Example 1.

[0054] (2) Case information

[0055] A total of 108 patients were included in the observation, whose age ranged from 3 to 58 years, and the course of disease was 6 to 72 months. They were divided into groups according to the blind method of random number form, including 54 cases in the experimental group and 54 cases in the control group. In the test group, there were 28 males and 26 females, with an average age of 29.01±7.23 years, and an average course of disease of 38.52±13.41 months; in the control group, there were 25 males and 29 females, with an average age of 31.09±6.49 years, and an average course of disease of 39.14±13.63 months. There was no difference between the two groups in terms of age, gender, smoking, drinking, body weig...

Embodiment 3

[0078] Embodiment 3 Concrete test case

[0079] 1. Name: Qin ×× Gender: Male Age: 24 years old

[0080] In September 2010, the patient developed edema of the eyelids and both lower limbs for no obvious reason or cause, accompanied by oliguria, increased foam in urine, sore waist and knees, and the edema gradually aggravated and spread to the whole body. Hospital tests showed: total protein 40.6g / L, albumin 23.4g / L, total cholesterol 10.9mmol / L, quantitative urine protein 7.66g / 24h, urine protein 3+, occult blood-. Renal biopsy showed: "minimal change nephropathy". When oral prednisone 60mg / d was given, it turned negative after 2 weeks, and the dosage was reduced by 5mg every month. During the reduction process, the relapse occurred many times. Whenever the hormone was reduced to 5mg / d, the urine protein reappeared, accompanied by the symptoms of both lower extremities. Edema.

[0081] In October 2011, the urine protein was 2+, the albumin was 30g / L, the total cholesterol wa...

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Abstract

The invention discloses a traditional Chinese medicine composition which comprises 5-10 parts of schisandra propinqua, 6-15 parts of herba gerberae piloselloidis, 3-15 parts of rhizoma corydalis, 15-25 parts of schefflera arboricola, 9-15 parts of raw malt, 10-15 parts of caulis spatholobi, 25-50 parts of obcordateleaf raspberry fruits or 50-100 parts of fresh obcordateleaf raspberry fruits, 30-60 parts of barley roots or 60-120 parts of fresh barley roots and 3-10 parts of liquorice. The composition can be used for preparing a drug for treating nephrotic syndromes so as to remarkably improve the symptoms of nephrotic syndrome patients and improve the treatment effect; the recovery rate can reach more than 92.6%, the health condition of the nephrotic syndrome patients can be effectively improved, and the living quality of the nephrotic syndrome patients is improved.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition and its application in preparing medicines for treating nephrotic syndrome. Background technique [0002] Nephrotic syndrome (NS) refers to a group of syndromes caused by various etiologies, mainly glomerular lesions such as increased glomerular basement membrane permeability and decreased glomerular filtration rate. The clinical manifestations are a group of clinical syndromes of massive proteinuria (>3.5g / d), hypoalbuminemia (<30g / L), high edema, and hyperlipidemia, the so-called "three highs and one low". [0003] At present, nephrotic syndrome mainly adopts the following drugs or methods for treatment: [0004] 1. Glucocorticoids Glucocorticoids are used for kidney diseases mainly because of their anti-inflammatory effect. It can reduce exudation during acute inflammation, stabilize lysosomal membrane,...

Claims

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Application Information

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IPC IPC(8): A61K36/8998A61P13/12
CPCA61K9/0095A61K36/25A61K36/28A61K36/484A61K36/486A61K36/57A61K36/66A61K36/73A61K36/8994A61K36/8998A61K2300/00
Inventor 曹希同尹朝晖
Owner 石家庄合泰恒医院股份有限公司
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