Serum miRNA maker assemblage for detecting nonalcoholic fatty liver, and its application

A non-alcoholic and fatty liver technology, applied in the combination and application field of serum miRNA markers, can solve the problems of low specificity, insufficient sensitivity, constraints, etc., and achieve the effect of rapid discovery
CN104293908AInactive Publication Date: 2015-01-21镇江市第三人民医院
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
镇江市第三人民医院
Publication Date
2015-01-21
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the field of biotechnology, and relates to a serum miRNA maker assemblage for detecting nonalcoholic fatty liver, and its application. The serum miRNA maker assemblage for detecting nonalcoholic fatty liver includes the following four has-microRNAs: hsa-miR-122-5p, hsa-miR-1290, hsa-miR-27b-3p and hsa-miR-192- 5p. The serum miRNA maker assemblage can realize early detection and rapid noninvasive detection of the nonalcoholic fatty liver.
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Description

technical field

[0001] The invention relates to the field of biological technology, and relates to a combination and application of serum miRNA markers for distinguishing non-alcoholic fatty liver from normal people. Background technique

[0002] Nonalcoholic fatty liver disease (NAFLD) refers to a clinicopathological syndrome characterized by diffuse bullous steatosis in hepatocytes, excluding excessive alcohol consumption and other definite liver damage factors. A large number of epidemiological studies have shown that NAFLD has become a common chronic liver disease with a global trend. With the increase of obesity and related metabolic disorders, the prevalence of NAFLD in my country has increased rapidly in the past 10 years. Liver histological examination is still the gold standard for the diagnosis of NAFLD, but the side effects and limitations of liver biopsy often restrict the development of this diagnostic technique. Therefore, finding new diagnostic markers and n...

Claims

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