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Serum miRNA maker assemblage for detecting nonalcoholic fatty liver, and its application

A non-alcoholic and fatty liver technology, applied in the combination and application field of serum miRNA markers, can solve the problems of low specificity, insufficient sensitivity, constraints, etc., and achieve the effect of rapid discovery

Inactive Publication Date: 2015-01-21
镇江市第三人民医院
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  • Abstract
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Problems solved by technology

However, each has its own shortcomings, such as low specificity and insufficient sensitivity, which restrict its application.

Method used

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  • Serum miRNA maker assemblage for detecting nonalcoholic fatty liver, and its application
  • Serum miRNA maker assemblage for detecting nonalcoholic fatty liver, and its application
  • Serum miRNA maker assemblage for detecting nonalcoholic fatty liver, and its application

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[0020] research object

[0021] The control group was healthy volunteers; the experimental group was NAFLD patients, with 20 NAFLD and 20 normal controls in the screening stage; 152 NAFLD in the training set, 90 normal controls; 103 NAFLD in the verification set, 80 normal controls, NAFLD patients came from outpatients and inpatients . All patients were screened by outpatient B-ultrasound. According to the research of Japanese scholars, any two or more of the following three abnormal abdominal ultrasound findings can be diagnosed as fatty liver: (1) Diffuse enhancement of liver near-field echo (bright liver), the echo intensity is higher than that of the kidney or spleen; (2) the intrahepatic pipeline structure is not clearly displayed; (3) the far-field echo of the liver gradually attenuates. The possibility of NAFLD should be highly suspected. Exclusion criteria 1. Exclude heavy drinking (ethanol intake >60g per day or >420g per week for men, >40g per day or >280g per week...

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Abstract

The invention belongs to the field of biotechnology, and relates to a serum miRNA maker assemblage for detecting nonalcoholic fatty liver, and its application. The serum miRNA maker assemblage for detecting nonalcoholic fatty liver includes the following four has-microRNAs: hsa-miR-122-5p, hsa-miR-1290, hsa-miR-27b-3p and hsa-miR-192- 5p. The serum miRNA maker assemblage can realize early detection and rapid noninvasive detection of the nonalcoholic fatty liver.

Description

technical field [0001] The invention relates to the field of biological technology, and relates to a combination and application of serum miRNA markers for distinguishing non-alcoholic fatty liver from normal people. Background technique [0002] Nonalcoholic fatty liver disease (NAFLD) refers to a clinicopathological syndrome characterized by diffuse bullous steatosis in hepatocytes, excluding excessive alcohol consumption and other definite liver damage factors. A large number of epidemiological studies have shown that NAFLD has become a common chronic liver disease with a global trend. With the increase of obesity and related metabolic disorders, the prevalence of NAFLD in my country has increased rapidly in the past 10 years. Liver histological examination is still the gold standard for the diagnosis of NAFLD, but the side effects and limitations of liver biopsy often restrict the development of this diagnostic technique. Therefore, finding new diagnostic markers and n...

Claims

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Application Information

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IPC IPC(8): C12Q1/68C12N15/11
CPCC12Q1/6883C12Q2600/178
Inventor 谭友文潘腾莉
Owner 镇江市第三人民医院
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