Method for the determination of soluble gpc3 protein

A variable and variable region technology, applied in immunoglobulin, chemical instruments and methods, specific peptides, etc., can solve the problem of 5-year survival rate retention
CN105849562BActive Publication Date: 2019-08-16CHUGAI PHARMA CO LTD +2
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
CHUGAI PHARMA CO LTD
Publication Date
2019-08-16

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Abstract

The present invention relates to a method for assaying soluble GPC3 protein in a test sample, comprising using two different antibodies binding to different epitopes present in the N-terminal region of GPC3 protein.
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Description

technical field

[0001] The present invention relates to a method for measuring soluble GPC3 protein in a test sample, characterized by using two different antibodies that bind to different epitopes present in the N-terminal region of the GPC3 protein. Background technique

[0002] It is reported that there are about 600,000 deaths per year caused by hepatocellular carcinoma, ranking fifth among the deaths caused by cancer in the world (Non-Patent Document 1). Most patients with HCC die within 1 year of diagnosis of the disease. Unfortunately, there are frequent instances of HCC being diagnosed at a later stage when curative therapies are less effective. Medical treatments, including chemotherapy, chemoembolization, cautery, and proton beam therapy, remain insufficiently effective in these patients. Most of the patients showed disease recurrence, which was accompanied by vascular invasion and multi-site intrahepatic metastases rapidly developed to the advanced stage, and th...

Claims

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