New application of traditional Chinese medicine compound medicinal composition

A kind of application and drug technology, applied in the field of traditional Chinese medicine compound pharmaceutical composition, can solve the problems of fetal placenta not having lethality, unable to identify and express trophoblast cells, etc., to improve maternal-fetal immune tolerance, have good clinical application prospects, and improve maternal-fetal immunity Tolerance effect

Active Publication Date: 2017-12-15
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented chemical called Zigugu pills (a type of drug) helps improve maternal resistance against diseases like abnormal childbirth or high blood pressure. It also increases levels of certain proteins involved with cellular regulation during fetal development. These changes help mothers become more likely to have children when they are born without compromising their own healthy body's ability to fight off harmful substances from other organisms.

Problems solved by technology

This patented technical problem addressed in the patents relates to improving maternity after childbirth due to lack of immunity from mothers who develop premature foetuses through natural selection processes like mating between sibling parents. Previous attempts at preventive therapy were focused solely towards reducing inflammation rather than promoting nurturing responses against these newborns. Therefore there was a demand for better understanding how the materno-to-maternal relationship works over time to improve future healthy offspring.

Method used

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  • New application of traditional Chinese medicine compound medicinal composition
  • New application of traditional Chinese medicine compound medicinal composition
  • New application of traditional Chinese medicine compound medicinal composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The preparation of embodiment 1 pharmaceutical composition of the present invention (Zuogui pill)

[0024] Weigh raw materials: Rehmannia glutinosa 200g, dodder 100g, achyranthes bidentata 75g, tortoise shell glue 100g, deer horn glue 100g, yam 100g, dogwood 100g, medlar 100g;

[0025] Preparation method: The above eight flavors, except for antler glue and tortoise shell glue, the other six flavors such as rehmannia glutinosa are crushed into fine powder, sieved and mixed. Take deer horn glue and tortoise shell glue to melt, and mix with the above fine powder. For every 100g of powder, add 10g of refined honey and an appropriate amount of water, pan pills, and dry to obtain; or without adding honey, it is only powder powder; or take powder, add pharmaceutically acceptable excipients or auxiliary ingredients to prepare granules, Tablets, capsules, oral liquids.

Embodiment 2

[0026] The preparation of embodiment 2 pharmaceutical compositions of the present invention

[0027] Weigh raw materials: Rehmannia glutinosa 18g, dodder 8g, achyranthes bidentata 1g, tortoise shell glue 1g, deer horn glue 8g, yam 8g, dogwood 9g, medlar 9g;

[0028] Prepare according to the method of Example 1.

Embodiment 3

[0029] The preparation of embodiment 3 pharmaceutical composition of the present invention

[0030] Weigh raw materials: Rehmannia glutinosa 30g, dodder 12g, achyranthes bidentata 16g, tortoise shell glue 16g, antler glue 16g, yam 16g, dogwood 12g, medlar 16g;

[0031] Prepare according to the method of Example 1.

[0032] The above-mentioned raw materials can use native medicine, also can use the processed product of native medicine.

[0033] The beneficial effect of the present invention is proved by drug efficacy experiment and clinical experiment as follows.

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Abstract

The invention discloses the application of a crude drug in preparation of a drug for improving fetal-maternal immunotolerance. The crude drug comprises the following components in parts by weight: 18 to 30 parts of radix rehmanniae preparata, 9 to 12 parts of cornus officinalis, 8 to 16 parts of rhizoma dioscoreae, 9 to 12 parts of Chinese wolfberries, 8 to 16 parts of cuscuta chinensis, 8 to 16 parts of deer-horn gelatin, 1 to 16 parts of radix cyathulae, and 1 to 16 parts of tortoise-plastron gelatin. The drug can improve fetal-maternal immunotolerance of parent substance, is expected to cure pathological pregnancy, such as habitual abortion, pregnancy-induced hypertension, IUCR and the like, caused by fetal-maternal immune imbalance, and has a good clinical application prospect.

Description

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Claims

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Application Information

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Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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