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Artemisia annua wax oil fatty acid and preparation method thereof

A kind of Artemisia annua and fatty acid technology, which is applied in the direction of fatty acid preparation/refining, fatty acid production, etc., can solve the problems of difficult development and utilization of Artemisia annua wax oil, heavy environmental pollution, etc., and achieve the effect of easy automatic control, simple operation, and increased added value

Inactive Publication Date: 2016-11-02
JISHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the above-mentioned technical problems of difficult development and utilization of Artemisia annua wax oil and heavy environmental pollution, the inventor finally invented a method for preparing fatty acids with Artemisia annua wax oil as the main raw material after long-term experiments, and obtained Artemisia annua wax oil Wax oil fatty acid products have strong physiological activity, health value and important industrial use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] (1) Use steam distillation to remove the volatile components in Artemisia annua wax oil;

[0020] (2) Add 2.1 times of 60-90 °C boiling range petroleum ether to dissolve wax oil of Artemisia annua wax oil in addition to volatile components, then filter, repeat twice, combine and concentrate the filtrate to obtain oil extract;

[0021] (3) Add excess NaOH-methanol solution with a mass fraction of 2% to the extract, reflux for 1.5 hours to completely saponify it, let stand, and filter to obtain fatty acid saponification;

[0022] (4) Add 0.25mol / L hydrochloric acid to the fatty acid saponification product to make the pH value 3.9, let it stand still, add ether to extract once, combine the ether layer, concentrate and recover the ether, and obtain Artemisia annua wax oil fatty acid.

[0023] The acid value, saponification value, and iodine value analysis of the obtained Artemisia annua wax oil fatty acid were carried out, and the results showed that the acid value was 141 ...

Embodiment 2

[0025] (1) Use steam distillation to remove the volatile components in Artemisia annua wax oil;

[0026] (2) Add 2.9 times of 60-90 °C boiling range petroleum ether to the Artemisia annua wax oil to remove volatile components to dissolve the wax oil, then filter, repeat 3 times, combine and concentrate the filtrate to obtain a grease extract;

[0027] (3) Add excess NaOH-methanol solution with a mass fraction of 1.1% to the extract, reflux for 2.8 hours to make it completely saponified, stand still, and filter to obtain fatty acid saponification;

[0028] (4) Add 0.5 mol / L hydrochloric acid to the fatty acid saponification product to make the pH value 3.1, let it stand still, add ether to extract 3 times, combine the ether layer, concentrate and recover the ether, and obtain Artemisia annua wax oil fatty acid.

[0029] The acid value, saponification value, and iodine value analysis of the obtained Artemisia annua wax oil fatty acid were carried out, and the results showed that...

Embodiment 3

[0031] (1) Use steam distillation to remove the volatile components in Artemisia annua wax oil;

[0032] (2) Add 2.6 times of 60-90 °C boiling range petroleum ether to dissolve wax oil of Artemisia annua wax oil in addition to volatile components, then filter, repeat twice, combine and concentrate the filtrate to obtain oil extract;

[0033] (3) Add excess NaOH-methanol solution with a mass fraction of 2.8% to the extract, reflux for 1.1 h to make it completely saponified, let stand, and filter to obtain fatty acid saponification;

[0034] (4) Add 0.75mol / L hydrochloric acid to the fatty acid saponification product to make the pH value 3.5, let it stand still, add diethyl ether to extract twice, combine the diethyl ether layer, concentrate and recover diethyl ether, and obtain Artemisia annua wax oil fatty acid.

[0035] The obtained Artemisia annua wax oil fatty acid was analyzed for acid value, saponification value, and iodine value. The results showed that the acid value wa...

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Abstract

The invention discloses an artemisia annua wax oil fatty acid and a preparation method thereof. The preparation method comprises the following steps: carrying out steam distillation on artemisia annua wax oil to remove volatile components, removing impurities, saponifying, reducing and extracting with ether to obtain artemisia annua wax oil fatty acid of which the acid number is 130-150, the saponification value is 150-170, the iodine value is 45-55, the content of saturated fatty acid is 32-36%, the content of monounsaturated fatty acid is 7-9% and the content of polyunsaturated fatty acid is 5-6%. The byproduct artemisia annua wax oil in the production process of artemisinin is used as a raw material, the preparation method of artemisia annua wax oil fatty acid is innovatively invented, the quality of artemisia annua wax oil fatty acid is detected and the physiological activity and health value of the artemisia annua wax oil fatty acid are further studied, the preparation method is of great significance for improving the additional value of artemisia annua wax oil fatty acid, widening the industrial paths of artemisia annua and protecting the environment and has broad application prospects.

Description

technical field [0001] The invention relates to a method for preparing fatty acid, in particular to a method for preparing fatty acid from Artemisia annua wax oil. Background technique [0002] Artemisia annua ( Artemisia annua L . ) is an annual herb of the genus Artemisia in the family Asteraceae. It is a traditional Chinese medicine in my country. The value of its active ingredient, artemisinin, in the prevention and treatment of malaria has been recognized and accepted by humans. Artemisia annua wax oil (wax oil) is the initial purification residue of artemisinin extracted from Artemisia annua organic solvent (8# solvent oil), dark in color, strong in smell, semi-solid, rich in volatile oil, chlorophyll, fatty acid, vegetable wax, etc. Chemical composition has important development value. At present, the production of 1 ton of artemisinin can produce about 5 tons of wax oil by-products. According to preliminary estimates, about 20 large-scale artemisinin production en...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C11C1/02
CPCC11C1/025
Inventor 张晓蓉
Owner JISHOU UNIVERSITY
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