Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Carbocisteine ​​oral solution and preparation method thereof

A technology of carbocisteine ​​and oral solution, applied in the field of medicine, can solve the problems of instability, poor water solubility of carbocisteine, and the solution is easily oxidized and placed for a long time.

Active Publication Date: 2017-09-12
BEIJING CHENG JI PHARMA
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is: provide a new preparation method of carbocisteine ​​oral solution to solve the problem of poor water solubility of carbocisteine, and solve the problem that the solution is easily oxidized and unstable for a long time

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Carbocisteine ​​oral solution and preparation method thereof
  • Carbocisteine ​​oral solution and preparation method thereof
  • Carbocisteine ​​oral solution and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0023] prescription:

[0024]

[0025] Weigh 200g of carbocisteine, add about 6L of water;

[0026] Slowly add about 0.95L of sodium hydroxide solution (dissolve 45g of sodium hydroxide in 1L of water to obtain a sodium hydroxide solution) into the solution (1), and keep stirring to completely dissolve the carbocisteine ​​(add 1:1 by molar ratio) alkali into salt);

[0027] Get the sodium sulfite of recipe quantity and add in the solution (2) and fully stir, obtain light yellow clear solution;

[0028] Get the sodium acetate of recipe quantity, chitosan and appropriate flavoring agent and add in the solution (3), fully stir to make it dissolve completely, measure the pH of the solution, now the pH of this light yellow clear solution should be 6.9-7.5. Then add water to make up to 10L;

[0029] Filter through a 0.22 μm filter membrane, fill the filtered medicinal solution into a 10ml brown medicinal oral solution bottle, and sterilize it with damp heat at 105°C for 20 min...

example 2

[0031] prescription:

[0032]

[0033]

[0034] Weigh 500g of carbocisteine, add about 6L of water;

[0035] Slowly add about 0.95L of sodium hydroxide solution (dissolve 112.5g of sodium hydroxide in 1L of water to obtain a sodium hydroxide solution) into the solution (1), and keep stirring to completely dissolve carbocisteine ​​(mole ratio 1:1 Add alkali to form salt);

[0036] Get the sodium metabisulfite of recipe quantity and add in the solution (2) and fully stir, obtain light yellow clear solution;

[0037] Get the sodium succinate of prescription quantity, chitosan and appropriate flavoring agent and add in the solution (3), fully stir to make it dissolve completely, measure the pH of solution, the pH of this light yellow clear solution should be 6.9-7.5 now. Then add water to make up to 10L;

[0038] Filter through a 0.22 μm filter membrane, fill the filtered medicinal solution into a 10ml brown medicinal oral solution bottle, and sterilize it with damp heat ...

example 3

[0040] prescription:

[0041]

[0042] Weigh 1000g of carbocisteine, add about 6L of water;

[0043] Slowly add about 0.95L of sodium hydroxide solution (dissolve 225g of sodium hydroxide in 1L of water to obtain a sodium hydroxide solution) into the solution (1), and keep stirring to completely dissolve the carbocisteine ​​(add 1:1 by molar ratio) alkali into salt);

[0044] Get the sodium bisulfite of recipe quantity and add in the solution (2) and fully stir, obtain light yellow clear solution;

[0045] Get the sodium succinate of recipe quantity, chitosan and appropriate flavoring agent and add in the solution (3), fully stir to make it dissolve completely, measure the pH of solution, now the pH of this light yellow clear solution should be 6.9-7.5. Then add water to make up to 10L;

[0046] Filter through a 0.22 μm filter membrane, fill the filtered medicinal solution into a 10ml brown medicinal oral solution bottle, and sterilize it with damp heat at 105°C for 20 m...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to a kind of carbocisteine ​​oral solution and preparation method thereof, described oral solution comprises 2%-10% carbocisteine, sodium hydroxide, antioxidant, solution stabilizer combination and corrective agent, its pH The value is 6.0‑7.5. The carbocisteine ​​is dissolved in water after being salted with sodium hydroxide solution, then added with antioxidant, solution stabilizer combination and flavoring agent, and prepared after stirring, constant volume, filtration, canning and sterilization (packaging Specification: 10-120ml / bottle). The oral solution medicine is widely used in the treatment of thick sputum or difficulty in expectoration caused by diseases such as chronic bronchitis and bronchial asthma. The oral solution provided by the invention has the characteristics of stable properties, long shelf life, safer clinical application and the like.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a pharmaceutical preparation and a preparation method thereof, in particular to a carbocisteine ​​oral solution and a preparation method thereof. technical background [0002] In view of carbocisteine ​​(carboxymethylcysteine) being a polyacid compound containing two carboxyl groups and an amino group, its solubility in water is only 0.16% (1.6g / L), and the compound preparation Oral solution, the effective drug concentration of this oral solution should be more than 5%, in order to increase the solubility of the compound in water, the present invention adopts the mode of adding alkali to form a salt (molar ratio 1: 1 to form a salt) to realize . And because the compound is a polybasic acid with amino groups, its aqueous solution after salt formation (by adding alkali at a molar ratio of 1:1 to form a salt) is weakly acidic (pH=6.2-6.8), and the weakly acidic aqueous solution should be store...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/36A61K47/12A61K47/04A61K31/198A61K9/08
Inventor 童丰郑玉胜
Owner BEIJING CHENG JI PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com