Carbocisteine oral solution and preparation method thereof
A technology of carbocisteine and oral solution, applied in the field of medicine, can solve the problems of instability, poor water solubility of carbocisteine, and the solution is easily oxidized and placed for a long time.
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example 1
[0023] prescription:
[0024]
[0025] Weigh 200g of carbocisteine, add about 6L of water;
[0026] Slowly add about 0.95L of sodium hydroxide solution (dissolve 45g of sodium hydroxide in 1L of water to obtain a sodium hydroxide solution) into the solution (1), and keep stirring to completely dissolve the carbocisteine (add 1:1 by molar ratio) alkali into salt);
[0027] Get the sodium sulfite of recipe quantity and add in the solution (2) and fully stir, obtain light yellow clear solution;
[0028] Get the sodium acetate of recipe quantity, chitosan and appropriate flavoring agent and add in the solution (3), fully stir to make it dissolve completely, measure the pH of the solution, now the pH of this light yellow clear solution should be 6.9-7.5. Then add water to make up to 10L;
[0029] Filter through a 0.22 μm filter membrane, fill the filtered medicinal solution into a 10ml brown medicinal oral solution bottle, and sterilize it with damp heat at 105°C for 20 min...
example 2
[0031] prescription:
[0032]
[0033]
[0034] Weigh 500g of carbocisteine, add about 6L of water;
[0035] Slowly add about 0.95L of sodium hydroxide solution (dissolve 112.5g of sodium hydroxide in 1L of water to obtain a sodium hydroxide solution) into the solution (1), and keep stirring to completely dissolve carbocisteine (mole ratio 1:1 Add alkali to form salt);
[0036] Get the sodium metabisulfite of recipe quantity and add in the solution (2) and fully stir, obtain light yellow clear solution;
[0037] Get the sodium succinate of prescription quantity, chitosan and appropriate flavoring agent and add in the solution (3), fully stir to make it dissolve completely, measure the pH of solution, the pH of this light yellow clear solution should be 6.9-7.5 now. Then add water to make up to 10L;
[0038] Filter through a 0.22 μm filter membrane, fill the filtered medicinal solution into a 10ml brown medicinal oral solution bottle, and sterilize it with damp heat ...
example 3
[0040] prescription:
[0041]
[0042] Weigh 1000g of carbocisteine, add about 6L of water;
[0043] Slowly add about 0.95L of sodium hydroxide solution (dissolve 225g of sodium hydroxide in 1L of water to obtain a sodium hydroxide solution) into the solution (1), and keep stirring to completely dissolve the carbocisteine (add 1:1 by molar ratio) alkali into salt);
[0044] Get the sodium bisulfite of recipe quantity and add in the solution (2) and fully stir, obtain light yellow clear solution;
[0045] Get the sodium succinate of recipe quantity, chitosan and appropriate flavoring agent and add in the solution (3), fully stir to make it dissolve completely, measure the pH of solution, now the pH of this light yellow clear solution should be 6.9-7.5. Then add water to make up to 10L;
[0046] Filter through a 0.22 μm filter membrane, fill the filtered medicinal solution into a 10ml brown medicinal oral solution bottle, and sterilize it with damp heat at 105°C for 20 m...
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