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Preparation method of high-dissolution-rate fenbendazole medicinal preparation

A technology of fenbendazole and pharmaceutical preparations, which is applied in the field of preparation technology of the anthelmintic drug fenbendazole, can solve the problems of low dissolution rate, low drug efficacy, large addition amount, etc., and achieve the effect of improving dissolution efficiency

Active Publication Date: 2015-04-22
ZHEJIANG WANFANG BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved in the present invention is to provide a preparation method of a high-dissolution fenbendazole pharmaceutical preparation, which overcomes the problems such as low drug efficacy and large addition amount caused by low dissolution in simple premixes, so as to achieve The purpose of improving the effect of drug use, reducing the amount of addition, and reducing environmental pollution

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1: Preparation method of 5% fenbendazole high dissolution rate preparation

[0021] Raw materials and auxiliary materials: 50 kg of drug-grade fenbendazole raw material, 150 kg of food-grade solvent triethanolamine, 50 kg of food-grade emulsifier Tween-80, 250 kg of food-grade silicon dioxide, and 500 kg of starch.

[0022] Main equipment: 500L dissolving cylinder with stirring, one 2000L mixing machine.

[0023] In the first step of preparation, 150 kg of food grade solvent triethanolamine is placed in a 500L dissolving tank, 50 kg of pharmaceutical grade fenbendazole raw material is added, and stirring is started at 30-60 rpm. At the same time, heat through the interlayer of the dissolving cylinder to slowly heat the temperature to about 160 degrees, and maintain it for 30-60 minutes until the raw drug is completely dissolved and the solution is clarified.

[0024] In the second step of preparation, add 50 kg of prepared food-grade emulsifier into the abo...

Embodiment 2

[0026] Embodiment 2: Preparation method of 10% fenbendazole high dissolution preparation

[0027] Raw materials and auxiliary materials: 100 kg of drug-grade fenbendazole raw material, 300 kg of food-grade solvent triethanolamine, 100 kg of food-grade emulsifier Tween-80, and 500 kg of food-grade silicon dioxide.

[0028] Main equipment: 1000L dissolving tank with stirring, one 2000L mixing machine.

[0029] In the first step of preparation, 300 kg of food grade solvent triethanolamine is placed in a 500L dissolving tank, 100 kg of pharmaceutical grade fenbendazole raw material is added, and stirring is started at 30-60 rpm. At the same time, heat through the interlayer of the dissolving cylinder to slowly heat the temperature to about 160 degrees, and maintain it for 30-60 minutes until the raw drug is completely dissolved and the solution is clarified.

[0030] In the second step of preparation, add 100 kg of prepared food-grade emulsifier into the above solution and keep...

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Abstract

The invention relates to a technology for preparing high-dissolution-rate antiparasitic drug fenbendazole and belongs to the field of veterinary preparation. A preparation method of the high-dissolution-rate antiparasitic drug fenbendazole comprises the following steps: adding a fenbendazole crude drug in food grade solvent, heating to dissolving fenbendazole, and preparing fenbendazole solution; adding a food grade emulsifying agent in the fenbendazole solution, and stirring, so that the food grade emulsifying agent is uniformly dispersed, and fenbendazole emulsion is obtained; slowly adding the fenbendazole emulsion into a food grade adsorbent, mixing, stirring continuously, and thus the high-dissolution-rate fenbendazole solid pharmaceutical preparation can be prepared. The high-dissolution-rate antiparasitic drug fenbendazole has the advantages that dissolution efficiency of insoluble fenbendazole in a gastrointestinal tract is improved to the utmost extent, and dissolution rate is increased to more than 70% from the original less than 1%.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations and relates to a preparation process of fenbendazole, an anthelmintic drug with high dissolution rate. Background technique [0002] Fenbendazole is a good anthelmintic drug that can be used for livestock according to the Ministry of Agriculture of my country. Fenbendazole is a new type of benzimidazole anthelmintic with broad spectrum, high efficiency and low toxicity. It not only has high anthelmintic activity against adults and larvae of animal gastrointestinal nematodes, but also has better effects against Dictyocaulus, Dicoelax lanceolata, Fasciola and tapeworm. In foreign countries, fenbendazole is not only used for various animals, but also has special preparations for wild animals. [0003] The raw material drug of fenbendazole is white or off-white powder, odorless and tasteless. Insoluble in water, slightly soluble in methanol, soluble in dimethyl sulfoxide and glacial acet...

Claims

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Application Information

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IPC IPC(8): A61K31/4184A61K47/34A61K47/04A61K47/36A61P33/02A61P33/10
Inventor 刘金松李慧杨彩梅倪兵兵
Owner ZHEJIANG WANFANG BIO TECH CO LTD
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