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Application of spearmint essential oil in preparation of medicine for treating allergic dermatitis

A spearmint, allergy technology, applied in the field of new drug use, can solve problems such as obvious side effects, and achieve the effects of reducing inflammation, alleviating passive skin allergic reactions, and reducing mast cell degranulation

Active Publication Date: 2015-04-22
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing therapeutic drugs are mainly hormones, but their side effects are relatively obvious

Method used

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  • Application of spearmint essential oil in preparation of medicine for treating allergic dermatitis
  • Application of spearmint essential oil in preparation of medicine for treating allergic dermatitis
  • Application of spearmint essential oil in preparation of medicine for treating allergic dermatitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] The extraction of embodiment 1 spearmint essential oil

[0017] Wrap 15g of spearmint stem powder with a filter paper pouch, place in a Soxhlet extractor, add 100ml of a mixed solution of absolute ethanol and ether, the volume ratio of the absolute alcohol and ether is 40:40, and heat to 80°C in a water bath . After repeated extractions, stop until the color in the flask is almost the same as that of the new leaching solution. Transfer the crude extract of spearmint essential oil to a beaker, add 1 g of activated carbon, heat to boiling, and stir from time to time, filter after cooling, and collect the filtrate. Evaporate the solvent therein with a rotary evaporator connected with a decompression pump, and collect the remaining liquid after evaporation to be the spearmint essential oil.

Embodiment 2

[0018] The extraction of embodiment 2 spearmint essential oil

[0019] Wrap 15g of spearmint stem powder with a filter paper pouch, place in a Soxhlet extractor, add 100ml of a mixed solution of absolute ethanol and ether, the volume ratio of the absolute alcohol and ether is 40:80, and heat to 90°C in a water bath . After repeated extractions, stop until the color in the flask is almost the same as that of the new leaching solution. Transfer the crude extract of spearmint essential oil to a beaker, add 1 g of activated carbon, heat to boiling, and stir from time to time, filter after cooling, and collect the filtrate. Evaporate the solvent therein with a rotary evaporator connected with a decompression pump, and collect the remaining liquid after evaporation to be the spearmint essential oil.

Embodiment 3

[0020] The extraction of embodiment 3 spearmint essential oil

[0021] Wrap 15g of spearmint stem powder with a filter paper pouch, place it in a Soxhlet extractor, add 100ml of a mixed solution of absolute ethanol and ether, the volume ratio of the absolute alcohol and ether is 40:60, and heat to 100°C in a water bath . After repeated extractions, stop until the color in the flask is almost the same as that of the new leaching solution. Transfer the crude extract of spearmint essential oil to a beaker, add 1 g of activated carbon, heat to boiling, and stir from time to time, filter after cooling, and collect the filtrate. Evaporate the solvent therein with a rotary evaporator connected with a decompression pump, and collect the remaining liquid after evaporation to be the spearmint essential oil.

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PUM

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Abstract

The invention discloses application of spearmint essential oil in preparation of a medicine for treating allergic dermatitis. Compared with the prior art, the spearmint essential oil in the method disclosed by the invention is capable of stabilizing mast cell membranes, reducing mast cell degranulation, inhibiting release of histamine and beta-hexosaminidase, reducing inflammatory reaction, reducing capillary permeability and relieving passive cutaneous allergic reaction.

Description

technical field [0001] The invention relates to the application of spearmint essential oil in the preparation of medicines for treating allergic skin diseases, belonging to the field of new medicine applications. Background technique [0002] Allergic skin diseases are skin diseases caused by allergens, specific allergens include contact allergens, inhalation allergens, ingestion allergens and injection allergens. Each type of allergen can cause corresponding allergic skin diseases, the main manifestations are various dermatitis, eczema, urticaria, drug eruption, contact dermatitis and so on. With air pollution, abuse of pesticides, premature use and abuse of antibiotics by infants and young children, increasing abundance of food or increased mental stress, the number of patients is gradually increasing, which seriously affects human health. Existing therapeutic drugs are mainly hormones, but their side effects are relatively obvious. Contents of the invention [0003] T...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/534A61P17/00A61P37/08
Inventor 易宏伟
Owner SOUTHEAST UNIV
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