A real-time positioning system for eyeball tumors based on eyeball movement features

Abstract

The invention discloses an eyeball tumor area real-time positioning method based on motion features of an eyeball. The eyeball tumor area real-time positioning method comprises the following steps of extracting an eye anterior-segment tissue information, conducting calibration and three-dimensional reconstruction on the eye anterior-segment tissue information to obtain shifting parameters before and after eyeball motion, establishing a three-dimensional eyeball model based on a CT image, and establishing the coordinate relation between an eye anterior segment feature structure and an intraocular tumor position. According to the eyeball tumor area real-time positioning method, an anterior-segment image obtained through real-time OCT tracking is utilized, and then the tumor is accurately positioned in a radiation area through processing technologies including image reconstruction, registering and the like. The invention further discloses an imaging device for extracting the eye anterior-segment tissue information. The imaging device for extracting the eye anterior-segment tissue information comprises an OCT light source, a beam splitter, a sample arm, a reference arm and a feedback device. A real-time positioning tracking system provides in-vitro noninvasive positioning and can achieve the purposes of improving positioning accuracy and radiation dose and local control rate of the ocular tumor, decreasing surrounding normal radiation dose and injury and the like.

Description

technical field [0001] The invention relates to a method for locating a specific eyeball region based on eyeball movement characteristics, in particular to a method for locating the eyeball region by using optical coherence tomography technology and an imaging device for extracting anterior segment tissue information. Background technique [0002] Radiation therapy is one of the important methods for eye tumors, especially for tumors such as choroidal melanoma, retinal glioma, pediatric rhabdomyosarcoma, intraocular lymphoma and uveal melanoma. Give the tumor target area a large enough radiation dose through precise external beam radiation technology, and avoid damage to the surrounding normal tissues (optic nerve, spots, ciliary body and crystal) through a steep dose gradient around the tumor, and improve the tumor target area. Precise radiation can effectively protect the eyesight of patients with eye tumors and the normal function of the eyeball. [0003] However, no mat...

AI Technical Summary

Problems solved by technology

However, this opaque chip positioning that relies on surgical placement makes precise radiotherapy an invasive treatment modality, and chip placement requires high surgical skill and risks of bleeding or scleral perforation

In addition, under certain circumstances, the metal chip outside the implant may form a dose shadow area, resulting in insufficient tumor dose and affecting the local control rate of the tumor.

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