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Application of degalactotigonin and derivative thereof in preparation of broad-spectrum antitumor medicine

A technology of removing galactosides and anti-tumor drugs, applied in the field of medicine, can solve the problems of large side effects, ineffective tumors, high toxicity, etc., and achieve the effects of easy extraction and separation, broad-spectrum anti-tumor, and stable properties

Inactive Publication Date: 2015-04-29
GUIZHOU INST OF BIOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing treatments often have the disadvantage of large side effects
Most of the existing chemotherapy drugs have the disadvantages of high toxicity and great damage to healthy human cells
At the same time, due to the drug resistance of tumor cells and other reasons, the existing therapeutic drugs or methods are not very effective for some tumors.

Method used

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  • Application of degalactotigonin and derivative thereof in preparation of broad-spectrum antitumor medicine
  • Application of degalactotigonin and derivative thereof in preparation of broad-spectrum antitumor medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The preparation of embodiment 1 degalactose substitute saponin

[0018] Crush and dry 1 kg of whole herb with 5 times the volume of 70% ethanol. After the extract is dried, extract it with 2 times the volume of n-butanol, and then use chloroform:methanol=1: 1 ratio for elution, the amount of the solvent used is twice the amount of the extraction solution, and then Sephadex-LH20 and preparative liquid phase for purification and recrystallization to obtain desgalactotigonin.

Embodiment 2

[0019] The preparation of embodiment 2 de-galactose substitute saponins

[0020] Crush and dry 1 kg of the whole herb with 10 times the volume of 50% ethanol. After the extract is dried, extract it with 5 times the volume of n-butanol, and then use chloroform:methanol=1: 1 ratio for elution, the amount of the solvent used is 4 times the amount of the extraction solution, and then Sephadex-LH20 and preparative liquid phase for purification and recrystallization to obtain desgalactotigonin.

Embodiment 3

[0021] The preparation of embodiment 3 degalactose substitute saponins

[0022] Crush and dry 1 kg of the whole herb with 8 times the volume of 60% ethanol. After the extract is dried, extract it with 3 times the volume of n-butanol, and then use chloroform:methanol=1: 1 ratio for elution, the amount of the solvent used is 3 times the amount of the extraction solution, and then Sephadex-LH20 and preparative liquid phase for purification and recrystallization to obtain desgalactotigonin.

[0023] Determination of anti-tumor effect of desgalactotigonin:

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Abstract

The invention relates to application of degalactotigonin and a derivative thereof in preparation of an antitumor medicine. The nightshade Solanum Linn is extracted and separated from the compound. A pharmacological experiment proves that the degalactotigonin has high inhibition rate on tumor cells at a certain concentration; the anti-patent activity of degalactotigonin is obviously higher than that of a positive medicine 10-hydroxycamptothecine; the desgalactotigonin has relatively low toxicity on normal cells, and can be used for treating tumor diseases such as liver cancer, lung cancer, gastric cancer, colon cancer, breast cancer, ovarian cancer, oral cancer, esophagus cancer, bile duct cancer and leukemia. The invention further discloses a method for extracting degalactotigonin from plants. The method is simple and feasible, and has a good industrial prospect.

Description

technical field [0001] The invention relates to the application of desgalactotigonin and its derivatives in the preparation of spectrum antitumor drugs, and belongs to the technical field of medicine. Background technique [0002] Tumor is a new organism formed by the body under the action of various carcinogenic factors, a certain cell in the local tissue loses its normal regulation of its growth at the gene level, resulting in abnormal clonal proliferation. Tumor is a disease that seriously endangers human health. Its death rate ranks second in many countries, second only to cardiovascular diseases. The methods usually used to treat tumors are surgery, chemotherapy and radiotherapy. Existing treatment methods often have the disadvantage of great side effects. Most of the existing chemotherapeutic drugs have the disadvantages of high toxicity and great damage to healthy human cells. At the same time, due to the drug resistance of tumor cells and other reasons, the existi...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P35/00A61P35/02
CPCA61K31/7048
Inventor 贾强
Owner GUIZHOU INST OF BIOLOGY