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Compound montmorillonite povidone iodine ointment and preparation method and application thereof

The technology of compound montmorillonite povidone and ointment is applied in the field of medicine and can solve scald ulcers, calf ulcers, post-herpetic ulcers, diabetic ulcers, postoperative ulcers, unsatisfactory treatment effects, and difficult wound surfaces. Healing and other problems, to achieve the effect of promoting rapid healing, accelerating the formation of granulation tissue, and good clinical effect

Active Publication Date: 2015-06-10
SHANDONG SBOND PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If the raw materials, auxiliary materials and production conditions used in the preparation are not sterilized or the sterilization method is improper, it is easy to cause secondary infection in clinical practice, making it more difficult to heal the wound surface, resulting in unsatisfactory treatment effect or greater damage to the ulcer surface. harm
In addition, the compound montmorillonite povidone-iodine ointment specially used for the treatment of skin ulcers (decubitus, scald ulcers, calf ulcers, postherpetic ulcers, diabetic ulcers, and postoperative ulcers), especially the compound montmorillonite Povidone-iodine ointment preparation has not been reported yet

Method used

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  • Compound montmorillonite povidone iodine ointment and preparation method and application thereof
  • Compound montmorillonite povidone iodine ointment and preparation method and application thereof
  • Compound montmorillonite povidone iodine ointment and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0157] Embodiment 1: the preparation of compound montmorillonite povidone-iodine ointment

[0158] 1. The proportion of raw and auxiliary materials (w / w):

[0159]

[0160]

[0161] 2. Prepare as follows:

[0162] (1) Take montmorillonite, povidone-iodine, polyethylene glycol 1000, glycerin, poloxamer 188, potassium iodide by proportioning for subsequent use;

[0163] (2) Add montmorillonite to sterile water, ultrasonically disperse for 30 minutes, control the temperature at 38°C, and ultrasonic frequency at 40KHz to obtain a suspoemulsion;

[0164] (3) The suspoemulsion prepared in step (2) was sterilized by ultrasonic at 35KHz for 30min at a temperature of 150°C, then cooled to 60°C, and kept warm for later use;

[0165] (4) Put polyethylene glycol 1000, glycerin, and poloxamer 188 into the tank, add sterile water and stir, adjust the pH value to 4.2 with citric acid and sodium hydroxide, continue to stir and heat up until completely stirred , continue to heat up to...

Embodiment 2

[0173] Embodiment 2: the preparation of compound montmorillonite povidone-iodine ointment

[0174] 1. The proportion of raw and auxiliary materials (w / w):

[0175]

[0176] 2. Prepare as follows:

[0177] (1) Take montmorillonite, povidone-iodine, polyethylene glycol 1000, glycerin, poloxamer 188, potassium iodide by proportioning for subsequent use;

[0178] (2) Add montmorillonite to sterile water, ultrasonically disperse for 50 minutes, control the temperature at 60°C, and ultrasonic frequency at 40KHz to obtain a suspoemulsion;

[0179] (3) The suspoemulsion prepared in step (2) was sterilized by ultrasonic at 35KHz for 30min at a temperature of 160°C, then cooled to 70°C, and kept warm for later use;

[0180] (4) Put polyethylene glycol 1000, glycerin, and poloxamer 188 into the tank, add sterile water and stir, adjust the pH value to 4.0 with citric acid and sodium hydroxide, continue to stir and heat up until completely stirred , continue to heat up to 140°C, and ...

Embodiment 3

[0188] Embodiment 3: the preparation of compound montmorillonite povidone-iodine ointment

[0189] 1. The proportion of raw and auxiliary materials (w / w):

[0190]

[0191] 2. Prepare as follows:

[0192] (1) Take montmorillonite, povidone-iodine, polyethylene glycol 1000, glycerin, poloxamer 188, potassium iodide by proportioning for subsequent use;

[0193] (2) Add montmorillonite into sterile water, ultrasonically disperse for 35 minutes, control the temperature at 50°C, and ultrasonic frequency at 35KHz to obtain a suspoemulsion;

[0194] (3) The suspoemulsion prepared in step (2) was sterilized by ultrasonication at 30KHz for 40min at a temperature of 155°C, then cooled to 60°C, and kept warm for later use;

[0195] (4) Put polyethylene glycol 1000, glycerin, and poloxamer 188 into the tank, add sterile water and stir, adjust the pH value to 4.5 with citric acid and sodium hydroxide, continue to stir and heat up until completely stirred , continue to heat up to 135°...

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PUM

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Abstract

The invention discloses compound montmorillonite povidone iodine ointment for treating skin ulcers and a preparation method and application thereof. The ointment is made of, by mass, 70-90 parts of montmorillonite, 3-5 parts of povidone iodine, 3-6 parts of polyethylene glycol 1000, 3-6 parts of glycerin, 2-5 parts of poloxamer 188, 2-3 parts of potassium iodide and 400-500 parts of sterile water. According to the compound montmorillonite povidone iodine ointment, montmorillonite and povidone iodine are used as the effective constituents of the ointment and are made to the medicament with pharmaceutic adjuvant, external used medicines are delivered for skin, and the ointment has the effects of sterilization, drying and convergent granulation promotion for treatment of bedsores at different times and skin ulcers caused by diabetic complications.

Description

technical field [0001] The invention relates to a pharmaceutical composition and its preparation method and application, relates to a compound montmorillonite povidone-iodine ointment for treating skin ulcers and its preparation method and application, and belongs to the technical field of medicine. Background technique [0002] Skin ulcer is a kind of frequently-occurring disease, common disease in traditional Chinese medicine surgery. The etiology of this disease is relatively complicated, among which the ulcers caused by vascular diseases account for more than 70% of the total incidence, including dozens of diseases such as arterial ulcers, varicose ulcers, and vasculitis ulcers. There are infectious, neurological, physical and blood diseases and other factors. Clinically, it is often unhealed for a long time and lacks effective treatment methods. At present, domestic western medicine mostly adopts systemic and local comprehensive treatment in the treatment of skin ulce...

Claims

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Application Information

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IPC IPC(8): A61K33/06A61K47/34A61K9/06A61P17/02A61K31/79
Inventor 乔敏陈立宗袁武杰刘钢李红新孟震晓
Owner SHANDONG SBOND PHARMA
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